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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1967 1
1968 3
1969 4
1970 8
1971 10
1972 15
1973 12
1974 11
1975 15
1976 22
1977 9
1978 16
1979 9
1980 5
1981 7
1982 12
1983 12
1984 10
1985 13
1986 8
1987 20
1988 26
1989 24
1990 27
1991 29
1992 38
1993 35
1994 37
1995 35
1996 47
1997 45
1998 61
1999 57
2000 65
2001 94
2002 86
2003 111
2004 155
2005 161
2006 199
2007 264
2008 336
2009 339
2010 459
2011 548
2012 540
2013 583
2014 597
2015 562
2016 490
2017 495
2018 489
2019 295
2020 7
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6,708 results
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Page 1
Alternative Routes to the Click Method for the Synthesis of 1,2,3-Triazoles, an Important Heterocycle in Medicinal Chemistry.
da S M Forezi L, et al. Curr Top Med Chem 2018 - Review. PMID 30129413
Heterocyclic rings having nitrogen atoms are the molecular fragments most used in drug design by using the tools of medicinal chemistry. ...A number of articles have been published by us and others highlighting the synthetic and biological aspects of 1,2,3-triazoles. ...
Heterocyclic rings having nitrogen atoms are the molecular fragments most used in drug design by using the tools of medicinal chemistry
Exploring the Chemistry and Therapeutic Potential of Triazoles: A Comprehensive Literature Review.
Jain A and Piplani P. Mini Rev Med Chem 2019 - Review. PMID 30864516
Triazole is a valuable platform in medicinal chemistry, possessing assorted pharmacological properties, which could play a major role in the common mechanisms associated with various disorders like cancer, infections, inflammation, convulsions, oxidative stress and neurodegeneration. ...The authors amalgamated the chemistry, synthetic strategies and detailed pharmacological activities of the triazole nucleus in the present review. ...
Triazole is a valuable platform in medicinal chemistry, possessing assorted pharmacological properties, which could play a major role …
Click chemistry: 1,2,3-triazoles as pharmacophores.
Agalave SG, et al. Chem Asian J 2011 - Review. PMID 21954075
The copper(I)-catalyzed 1,2,3-triazole-forming reaction between azides and terminal alkynes has become the gold standard of 'click chemistry' due to its reliability, specificity, and biocompatibility. Applications of click chemistry are increasingly found in all aspects of drug discovery; they range from lead finding through combinatorial chemistry and target-templated in vitro chemistry, to proteomics and DNA research by using bioconjugation reactions. ...
The copper(I)-catalyzed 1,2,3-triazole-forming reaction between azides and terminal alkynes has become the gold standard of 'click chemis
Conazoles
Heeres J, et al. Molecules 2010 - Review. PMID 20657432 Free PMC article.
The chemistry, in vitro and in vivo antifungal activity, pharmacology, and clinical applications of these marketed conazoles has been described....
The chemistry, in vitro and in vivo antifungal activity, pharmacology, and clinical applications of these marketed conazoles has been …
Synthesis of α-amino-1,3-dicarbonyl compounds via Ugi flow chemistry reaction: access to functionalized 1,2,3-triazoles.
Vasconcelos SNS, et al. Mol Divers 2017. PMID 28702849
We present the rapid and efficient synthesis of [Formula: see text]-amino-1,3-dicarbonyl compounds in moderate to good yields via Ugi flow chemistry reactions performed with a continuous flow reactor. ...The [Formula: see text]-amino acid derivatives of the Ugi flow chemistry reaction products were then used for dipeptide synthesis....
We present the rapid and efficient synthesis of [Formula: see text]-amino-1,3-dicarbonyl compounds in moderate to good yields via Ugi flow …
Recent developments on triazole nucleus in anticonvulsant compounds: a review
Song MX and Deng XQ. J Enzyme Inhib Med Chem 2018 - Review. PMID 29383949 Free PMC article.
The search for new anticonvulsant agents with higher efficacy and lower toxicity continues to be the focus and task in medicinal chemistry. ...
The search for new anticonvulsant agents with higher efficacy and lower toxicity continues to be the focus and task in medicinal chemistr
Click chemistry inspired synthesis of morpholine-fused triazoles.
Mishra KB and Tiwari VK. J Org Chem 2014. PMID 24845771
The synthesis of triazolyl azido alcohols from terminal alkyne via oxirane ring-opening of epichlorohydrin, followed by click reaction with alkynes, and subsequent azidation of chlorohydroxy triazoles was achieved under a one-pot methodology. The developed triazolyl azido alcohols were further utilized for the synthesis of a diverse range of morpholine-fused triazoles of chemotherapeutic value. ...
The synthesis of triazolyl azido alcohols from terminal alkyne via oxirane ring-opening of epichlorohydrin, followed by click reaction with …
Investigation of copper-free alkyne/azide 1,3-dipolar cycloadditions using microwave irradiation
Chatkewitz LE, et al. Bioorg Med Chem Lett 2018. PMID 29248298 Free PMC article.
The prevalence of 1,3-dipolar cycloadditions of azides and alkynes within both biology and chemistry highlights the utility of these reactions. ...A small array of triazoles was prepared to examine the scope of this approach, and the methodology was translated to a protein context through the use of unnatural amino acids to demonstrate one of the first microwave-mediated bioconjugations involving a full length protein....
The prevalence of 1,3-dipolar cycloadditions of azides and alkynes within both biology and chemistry highlights the utility of these …
6,708 results
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