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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1981 2
1982 6
1983 17
1984 27
1985 25
1986 36
1987 25
1988 52
1989 52
1990 92
1991 164
1992 269
1993 435
1994 709
1995 950
1996 1172
1997 1430
1998 1654
1999 1825
2000 1951
2001 1984
2002 2021
2003 2029
2004 2074
2005 2121
2006 2296
2007 2327
2008 2360
2009 2545
2010 2653
2011 2889
2012 2878
2013 2954
2014 2863
2015 2773
2016 2685
2017 2487
2018 2265
2019 1129
2020 31
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51,444 results
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The role of tumor suppressor p53 in metabolism and energy regulation, and its implication in cancer and lifestyle-related diseases.
Hashimoto N, et al. Endocr J 2019 - Review. PMID 31105124 Free article.
The tumor suppressor gene p53 is mutated in approximately more than 50% of human cancers. p53 is also referred to as the "cellular gatekeeper" or "guardian of the genome" because it protects the body from spreading mutated genome induced by various stress. ...In addition, mutant p53 protein does not only lose the tumor suppressor function, but it also gains novel oncogenic function and contributes to tumor development, involving cellular metabolism modification. ...
The tumor suppressor gene p53 is mutated in approximately more than 50% of human cancers. p53 is also referred to as the "cell …
Iron regulatory protein 2 is a suppressor of mutant p53 in tumorigenesis.
Zhang Y, et al. Oncogene 2019. PMID 31332290
However, unlike its effect to suppress cell growth in cells carrying wild-type p53, loss of IRP2 promoted cell growth in cancer cells expressing mutant p53. Finally, we found that ectopic expression of IRP2 suppressed cell growth in a mutant p53-dependent manner. Together, our data indicate that mutant p53 gain-of-function can be suppressed by IRP2 and FDXR deficiency, both of which may be explored to target tumors carrying mutant p53....
However, unlike its effect to suppress cell growth in cells carrying wild-type p53, loss of IRP2 promoted cell growth in cancer cells …
DMPK is a New Candidate Mediator of Tumor Suppressor p53-Dependent Cell Death.
Itoh K, et al. Molecules 2019. PMID 31480541 Free PMC article.
Tumor suppressor p53 plays an integral role in DNA-damage induced apoptosis, a biological process that protects against tumor progression. ...
Tumor suppressor p53 plays an integral role in DNA-damage induced apoptosis, a biological process that protects against tum
KRAS-IRF2 Axis Drives Immune Suppression and Immune Therapy Resistance in Colorectal Cancer.
Liao W, et al. Cancer Cell 2019. PMID 30905761 Free PMC article.
KRAS(∗)-mediated repression of IRF2 results in high expression of CXCL3, which binds to CXCR2 on myeloid-derived suppressor cells and promotes their migration to the tumor microenvironment. ...
KRAS(∗)-mediated repression of IRF2 results in high expression of CXCL3, which binds to CXCR2 on myeloid-derived suppressor cells and …
Phase separation of 53BP1 determines liquid-like behavior of DNA repair compartments
Kilic S, et al. EMBO J 2019. PMID 31267591 Free PMC article.
Moreover, we found the tumor suppressor protein p53 to be enriched within 53BP1 optoDroplets, and conditions that disrupt 53BP1 phase separation impair 53BP1-dependent induction of p53 and diminish p53 target gene expression. ...
Moreover, we found the tumor suppressor protein p53 to be enriched within 53BP1 optoDroplets, and conditions that disrupt 53BP …
Tumor suppressor role of cytoplasmic polyadenylation element binding protein 2 (CPEB2) in human mammary epithelial cells.
Tordjman J, et al. BMC Cancer 2019. PMID 31185986 Free PMC article.
Tumor-suppressor p53 protein was shown to be a novel translationally-regulated target of CPEB2, validated with polysome profiling. ...Human breast cancer tissues (n = 105) revealed a lower mRNA expression for CPEB2 isoform A and also a lower A/B isoform ratio than in non-tumour breast tissues (n = 20), suggesting that CPEB2A accounts for the tumor-suppressor functions of CPEB2. ...
Tumor-suppressor p53 protein was shown to be a novel translationally-regulated target of CPEB2, validated with polysome profil
ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway.
Chu B, et al. Nat Cell Biol 2019. PMID 30962574 Free PMC article.
Thus, our study identifies an ALOX12-mediated, ACSL4-independent ferroptosis pathway that is critical for p53-dependent tumour suppression....
Thus, our study identifies an ALOX12-mediated, ACSL4-independent ferroptosis pathway that is critical for p53-dependent tumour suppressio
Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression.
Hu Q, et al. Nat Immunol 2019. PMID 31160797 Free PMC article.
Consequently, LINK-A expression enhanced K48-polyubiquitination-mediated degradation of the antigen peptide-loading complex (PLC) and intrinsic tumor suppressors Rb and p53. ...Hence we demonstrate lncRNA-dependent downregulation of antigenicity and intrinsic tumor suppression, which provides the basis for developing combinational immunotherapy treatment regimens and early TNBC prevention....
Consequently, LINK-A expression enhanced K48-polyubiquitination-mediated degradation of the antigen peptide-loading complex (PLC) and intrin …
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