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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1990 3
1991 38
1992 102
1993 170
1994 297
1995 302
1996 328
1997 325
1998 359
1999 365
2000 362
2001 318
2002 238
2003 232
2004 201
2005 194
2006 225
2007 193
2008 161
2009 151
2010 133
2011 126
2012 122
2013 149
2014 107
2015 116
2016 98
2017 84
2018 69
2019 29
2020 0
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5,363 results
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Page 1
A disposable immunosensor using ITO based electrode modified by a star-shaped polymer for analysis of tumor suppressor protein p53 in human serum.
Aydın M, et al. Biosens Bioelectron 2018. PMID 29425857
Label-free immunosensor based on tetra armed star-shaped poly(glycidylmethacrylate) (Star(PGMA)) modified disposable ITO electrode was developed for detection of p53 protein, an important colorectal cancer biomarker. ...After formation of a stable film with epoxy ends, anti-p53 antibodies were bound to these groups covalently. Stepwise modification of the electrode was followed by electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV) studies. ...
Label-free immunosensor based on tetra armed star-shaped poly(glycidylmethacrylate) (Star(PGMA)) modified disposable ITO electrode was devel …
Detection of p53 protein aggregation in cancer cell lines and tumor samples.
Yang-Hartwich Y, et al. Methods Mol Biol 2015. PMID 25308263
The p53 protein plays a central role in regulating apoptosis. The loss of functional p53 is common in many cancers. In cancer cells, the dysfunctional p53 protein often maintains a misfolded, inactive conformation due to genetic mutations or posttranslational deregulation. The misfolded p53 protein can aggregate and form amyloid-like oligomers and fibrils, which abrogate the pro-apoptotic functions of p53. ...
The p53 protein plays a central role in regulating apoptosis. The loss of functional p53 is common in many cancers. In …
Ultrasensitive electrochemical immunosensing of tumor suppressor protein p53 in unprocessed human plasma and cell lysates using a novel nanocomposite based on poly-cysteine/graphene quantum dots/gold nanoparticle.
Hasanzadeh M, et al. Int J Biol Macromol 2018. PMID 29113888
An ultrasensitive electrochemical immunosensor for quantitation of tumor suppressor protein p53 based on ternary signal amplification strategy was fabricated. ...Also, linear range and lower limit of quantification of p53 in unprocessed human plasma were 0.000592-1.296 pM and 0.065 fM, respectively. ...
An ultrasensitive electrochemical immunosensor for quantitation of tumor suppressor protein p53 based on ternary …
Electrochemical sensing of tumor suppressor protein p53-deoxyribonucleic acid complex stability at an electrified interface.
Paleček E, et al. Anal Chim Acta 2014. PMID 24845809
Here we utilize specific properties of constant current chronopotentiometric stripping (CPS) in the analysis of protein and DNA-protein complex nanolayers. ...Picomole amounts of p53 proteins and DNA were used for the analysis at full electrode coverage but we show that even 10-20-fold smaller amounts can be analyzed. ...
Here we utilize specific properties of constant current chronopotentiometric stripping (CPS) in the analysis of protein and DN …
Association of p53 protein expression with tumor cell proliferation rate and clinical outcome in node-negative breast cancer.
Allred DC, et al. J Natl Cancer Inst 1993. PMID 8423624
BACKGROUND: The p53 (also known as TP53) tumor suppressor gene encodes for a nuclear phosphoprotein thought to regulate proliferation of normal cells. ...In a multivariate analysis, expression of p53 protein and high %S phase were independently associated with reduced disease-free survival (P = .008 and .01, respectively). ...
BACKGROUND: The p53 (also known as TP53) tumor suppressor gene encodes for a nuclear phosphoprotein thought to regulate …
Tumor suppressor p53 mutations and breast cancer: a critical analysis.
Ozbun MA and Butel JS. Adv Cancer Res 1995 - Review. PMID 7793321
Alterations in the tumor suppressor gene p53 are the most commonly identified changes in cancer, including neoplasia of the breast. ...Mutation may lead to nuclear accumulation of p53 protein; however, inactivation of p53 by nuclear exclusion and interaction with the mdm2 protein also appear to be important in tumorigenesis. ...
Alterations in the tumor suppressor gene p53 are the most commonly identified changes in cancer, including neoplasia of …
Rapid colorimetric detection of p53 protein function using DNA-gold nanoconjugates with applications for drug discovery and cancer diagnostics.
Assah E, et al. Colloids Surf B Biointerfaces 2018. PMID 29778960
The tumor suppressor protein p53 plays a central role in preventing cancer through interaction with DNA response elements (REs) to regulate target gene expression in cells. ...The assay design is based on a concept that alters interparticle-distances between RE-AuNPs from a crosslinking effect induced through tetramerization of wildtype p53 protein (p53-WT) upon binding to canonical DNA motifs modified on gold nanoparticles (RE-AuNPs). ...
The tumor suppressor protein p53 plays a central role in preventing cancer through interaction with DNA response …
[The value of serum human tumor protein P53 in colorectal cancer combined diagnosis and postoperative monitoring].
Fan P, et al. Zhonghua Yi Xue Za Zhi 2017. PMID 28910954 Chinese.
Objective: The aim of this paper is to investigate the application value of serum human tumor protein P53 (TP53) in the diagnosis and postoperative monitoring of colorectal cancer. ...The levels of serum TP53 in patients with colorectal cancer show great discrepancies in different TNM stages, different tumor location, depth of invasion and lymph node metastasis (P<0.05) , but no difference in sex, age, and tumor growth type. ...
Objective: The aim of this paper is to investigate the application value of serum human tumor protein P53 (TP53) in the …
Highly sensitive fluorescent detection of p53 protein based on DNA functionalized Fe(3)O(4) nanoparticles.
Xu Q, et al. Talanta 2018. PMID 29853027
The accurate quantification of p53 protein expression level is of great importance for cancer diagnosis. Here, a highly sensitive fluorescent sensor based on DNA functionalized magnetic nanoparticles was developed for the detection of p53 protein expression. Instead of a monoclonal antibody, a consensus DNA was employed to capture p53 protein. Meanwhile the fluorescent dye tethered DNA was used as the signal output instead of enzyme tagged nanoparticle or antibody. ...
The accurate quantification of p53 protein expression level is of great importance for cancer diagnosis. Here, a highly sensit …
Expression of p53 protein and Ki-67 antigen in phyllodes tumor of the breast.
Chan YJ, et al. J Chin Med Assoc 2004. PMID 15077883
In addition to routine morphology, the studies of p53 protein and Ki-67 antigen expression in PT may be useful to differentiate benign from malignant tumors. ...The p53 protein expression showed a significant difference between benign and malignant lesions. Within the group of benign lesions, 5 out of 50 (10%) tumors had p53 expression > 10%, whereas nine out of 13 (69%) malignant tumors revealed p53 expression > 10% (p < 0.005). ...
In addition to routine morphology, the studies of p53 protein and Ki-67 antigen expression in PT may be useful to differentiat …
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