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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 5
1946 17
1947 20
1948 20
1949 22
1950 38
1951 34
1952 32
1953 38
1954 29
1955 36
1956 43
1957 49
1958 58
1959 50
1960 51
1961 63
1962 122
1963 238
1964 362
1965 283
1966 401
1967 478
1968 537
1969 592
1970 607
1971 759
1972 714
1973 656
1974 641
1975 502
1976 432
1977 434
1978 321
1979 357
1980 346
1981 319
1982 327
1983 326
1984 374
1985 363
1986 390
1987 349
1988 374
1989 468
1990 540
1991 672
1992 755
1993 929
1994 1106
1995 1134
1996 953
1997 1059
1998 1273
1999 1317
2000 1354
2001 1443
2002 1439
2003 1571
2004 1513
2005 1523
2006 1312
2007 1218
2008 1122
2009 1126
2010 1077
2011 1099
2012 1099
2013 1010
2014 873
2015 863
2016 745
2017 696
2018 644
2019 283
2020 5
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42,274 results
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Page 1
L-tyrosine supplementation does not ameliorate skeletal muscle dysfunction in zebrafish and mouse models of dominant skeletal muscle α-actin nemaline myopathy.
Messineo AM, et al. Sci Rep 2018. PMID 30065346 Free PMC article.
L-tyrosine supplementation may provide benefit to nemaline myopathy (NM) patients, however previous studies are inconclusive, with no elevation of L-tyrosine levels in blood or tissue reported. ...NM TgACTA1(D286G) mice consuming 2% L-tyrosine supplemented feed from preconception had significant elevations in free L-tyrosine levels in sera (57%) and quadriceps muscle (45%) when examined at 6-7 weeks old. ...
L-tyrosine supplementation may provide benefit to nemaline myopathy (NM) patients, however previous studies are inconclusive, with no …
Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair.
Ma J, et al. Cancer Cell 2019. PMID 30827889 Free PMC article.
We identified a mechanism of such resistance mediated by phosphorylation of PTEN on tyrosine 240 (pY240-PTEN) by FGFR2. pY240-PTEN is rapidly elevated and bound to chromatin through interaction with Ki-67 in response to IR treatment and facilitates the recruitment of RAD51 to promote DNA repair. ...
We identified a mechanism of such resistance mediated by phosphorylation of PTEN on tyrosine 240 (pY240-PTEN) by FGFR2. pY240-PTEN is …
ALK phosphorylates SMAD4 on tyrosine to disable TGF-β tumour suppressor functions.
Zhang Q, et al. Nat Cell Biol 2019. PMID 30664791
These findings reveal that SMAD4 is tyrosine-phosphorylated by an oncogenic tyrosine kinase during tumorigenesis. This suggests a mechanism by which SMAD4 is inactivated in cancers and provides guidance for targeted therapies in ALK-positive cancers....
These findings reveal that SMAD4 is tyrosine-phosphorylated by an oncogenic tyrosine kinase during tumorigenesis. This suggest …
YAP Tyrosine Phosphorylation and Nuclear Localization in Cholangiocarcinoma Cells Are Regulated by LCK and Independent of LATS Activity.
Sugihara T, et al. Mol Cancer Res 2018. PMID 29903769 Free PMC article.
However, YAP also undergoes tyrosine phosphorylation, and the role of tyrosine phosphorylation in YAP regulation remains unclear. Herein, YAP regulation by tyrosine phosphorylation was examined in human and mouse CCA cells, as well as patient-derived xenograft (PDX) models. ...
However, YAP also undergoes tyrosine phosphorylation, and the role of tyrosine phosphorylation in YAP regulation remains uncle …
Targeting SHP-1, 2 and SHIP Pathways: A Novel Strategy for Cancer Treatment?
Dempke WCM, et al. Oncology 2018 - Review. PMID 29925063
Well-balanced levels of tyrosine phosphorylation, maintained by the reversible and coordinated actions of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs), are critical for a wide range of cellular processes including growth, differentiation, metabolism, migration, and survival. Aberrant tyrosine phosphorylation, as a result of a perturbed balance between the activities of PTKs and PTPs, is linked to the pathogenesis of numerous human diseases, including cancer, suggesting that PTPs may be innovative molecular targets for cancer treatment. ...
Well-balanced levels of tyrosine phosphorylation, maintained by the reversible and coordinated actions of protein tyrosine kin …
A unique intracellular tyrosine in neuroligin-1 regulates AMPA receptor recruitment during synapse differentiation and potentiation.
Letellier M, et al. Nat Commun 2018. PMID 30266896 Free PMC article.
Screening of tyrosine kinases combined with pharmacological inhibitors point to Trk family members as major regulators of endogenous Nlg1 phosphorylation and synaptogenic function. Thus, Nlg1 tyrosine phosphorylation signaling is a critical event in excitatory synapse differentiation and LTP....
Screening of tyrosine kinases combined with pharmacological inhibitors point to Trk family members as major regulators of endogenous …
Tyrosine phosphorylation activates 6-phosphogluconate dehydrogenase and promotes tumor growth and radiation resistance.
Liu R, et al. Nat Commun 2019. PMID 30824700 Free PMC article.
Here we show that upon EGFR activation, 6PGD is phosphorylated at tyrosine (Y) 481 by Src family kinase Fyn. This phosphorylation enhances 6PGD activity by increasing its binding affinity to NADP(+) and therefore activates the PPP for NADPH and ribose-5-phosphate, which consequently detoxifies intracellular reactive oxygen species (ROS) and accelerates DNA synthesis. ...
Here we show that upon EGFR activation, 6PGD is phosphorylated at tyrosine (Y) 481 by Src family kinase Fyn. This phosphorylation enh …
Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism
Maini Rekdal V, et al. Science 2019. PMID 31196984
Conversion of l-dopa to dopamine by a pyridoxal phosphate-dependent tyrosine decarboxylase from Enterococcus faecalis is followed by transformation of dopamine to m-tyramine by a molybdenum-dependent dehydroxylase from Eggerthella lenta These enzymes predict drug metabolism in complex human gut microbiotas. ...
Conversion of l-dopa to dopamine by a pyridoxal phosphate-dependent tyrosine decarboxylase from Enterococcus faecalis is followed by …
PTPN14 regulates Roquin2 stability by tyrosine dephosphorylation.
Choi J, et al. Cell Cycle 2018. PMID 30209976 Free PMC article.
In this paper, we demonstrate that the mRNA decay factor Roquin2 is phosphorylated at tyrosine residue in position 691 in vivo. ...Furthermore, we establish that the tyrosine phosphatase PTPN14 specifically interacts with Roquin2 through its phosphatase domain and dephosphorylates Roquin2 tyrosine 691. ...
In this paper, we demonstrate that the mRNA decay factor Roquin2 is phosphorylated at tyrosine residue in position 691 in vivo. ...Fu …
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