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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1992 1
1993 7
1994 49
1995 94
1996 82
1997 100
1998 108
1999 122
2000 120
2001 139
2002 122
2003 142
2004 161
2005 206
2006 323
2007 393
2008 440
2009 444
2010 449
2011 508
2012 530
2013 533
2014 578
2015 583
2016 576
2017 588
2018 645
2019 636
2020 662
2021 663
2022 509
2023 36
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9,238 results
Results by year
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Page 1
Overexpression of Janus kinase 2 protein in extramammary Paget's disease.
Otsuka-Maeda S, Mijiddorj MT, Kajihara I, Sakamoto R, Yamada-Kanazawa S, Kanemaru H, Nishimura Y, Sawamura S, Makino K, Aoi J, Makino T, Masuguchi S, Fukushima S, Ihn H. Otsuka-Maeda S, et al. Jpn J Clin Oncol. 2021 Jul 1;51(7):1176-1178. doi: 10.1093/jjco/hyab062. Jpn J Clin Oncol. 2021. PMID: 33912910
Immunohistochemistry showed that most extramammary Paget's disease tissues were positive for Janus kinase 2 (50/53, 94.3%), and the immunostaining intensity of Janus kinase 2 was correlated with the degree of invasiveness, lymph node meta …
Immunohistochemistry showed that most extramammary Paget's disease tissues were positive for Janus kinase 2 (50/53, 94. …
The role of Janus kinase 2 (JAK2) in myeloproliferative neoplasms: therapeutic implications.
Quintás-Cardama A. Quintás-Cardama A. Leuk Res. 2013 Apr;37(4):465-72. doi: 10.1016/j.leukres.2012.12.006. Epub 2013 Jan 11. Leuk Res. 2013. PMID: 23313046 Review.
Data in animal models showed that JAK2 inhibitors target JAK2 V617F kinase and decrease disease burden. ...However, JAK2 inhibitors have limited ability to reduce JAK2 V617F allele burden or bone marrow fibrosis in humans. ...
Data in animal models showed that JAK2 inhibitors target JAK2 V617F kinase and decrease disease burden. ...However, …
Fedratinib: First Approval.
Blair HA. Blair HA. Drugs. 2019 Oct;79(15):1719-1725. doi: 10.1007/s40265-019-01205-x. Drugs. 2019. PMID: 31571162 Review.
Fedratinib (INREBIC()) is a JAK2-selective inhibitor that has been developed as an oral treatment for myelofibrosis. In August 2019, fedratinib received its first global approval in the USA for the treatment of adult patients with intermediate-2 or high-risk primary …
Fedratinib (INREBIC()) is a JAK2-selective inhibitor that has been developed as an oral treatment for myelofibrosis. In August 2019, …
CME: Polycythemia vera, myeloproliferative Neoplasie.
Bächli E, Gundelfinger M. Bächli E, et al. Praxis (Bern 1994). 2017 Jul;106(15):807-813. doi: 10.1024/1661-8157/a002740. Praxis (Bern 1994). 2017. PMID: 28745110 Review. German. No abstract available.
Adenosine-stimulated adrenal steroidogenesis involves the adenosine A2A and A2B receptors and the Janus kinase 2-mitogen-activated protein kinase kinase-extracellular signal-regulated kinase signaling pathway.
Chen YC, Huang SH, Wang SM. Chen YC, et al. Int J Biochem Cell Biol. 2008;40(12):2815-25. doi: 10.1016/j.biocel.2008.05.016. Epub 2008 Jun 5. Int J Biochem Cell Biol. 2008. PMID: 18582595
Inhibition of Janus kinase 2 prevented the adenosine-induced steroidogenesis and phosphorylation of mitogen-activated protein kinase kinase 1/2 and extracellular signal-regulated kinase 1/2, demonstrating that Janu …
Inhibition of Janus kinase 2 prevented the adenosine-induced steroidogenesis and phosphorylation of mitogen-activated …
Jak2 tyrosine kinase and cancer: how good cells get HiJAKed.
Godeny MD, Sayeski PP. Godeny MD, et al. Anticancer Agents Med Chem. 2007 Nov;7(6):643-50. doi: 10.2174/187152007782330105. Anticancer Agents Med Chem. 2007. PMID: 18045059 Review.
Cloned in 1992, Jak2 tyrosine kinase has emerged as a critical molecule in mammalian development, physiology, and disease. ...We also review how specific structural determinants within Jak2 dictate its overall function. Finally, we will review relative …
Cloned in 1992, Jak2 tyrosine kinase has emerged as a critical molecule in mammalian development, physiology, and disea …
Ruxolitinib.
Mesa RA, Yasothan U, Kirkpatrick P. Mesa RA, et al. Nat Rev Drug Discov. 2012 Feb 1;11(2):103-4. doi: 10.1038/nrd3652. Nat Rev Drug Discov. 2012. PMID: 22293561 No abstract available.
Janus kinase 2 and signal transducer and activator of transcription 3 activation is not essential for CCL3-, CCL5- or CCL8-induced chemotaxis.
Khabbazi S, Jacques RO, Moyano Cardaba C, Mueller A. Khabbazi S, et al. Cell Biochem Funct. 2013 Jun;31(4):312-8. doi: 10.1002/cbf.2901. Epub 2012 Sep 14. Cell Biochem Funct. 2013. PMID: 22987449
Therefore, we investigated here the molecular mechanisms of CCL3-, CCL5- and CCL8-induced cells migration and investigated whether the Janus kinase/signal transducer and activator of transcription (STAT) signalling pathway is involved. ...However, for inhibitors tha …
Therefore, we investigated here the molecular mechanisms of CCL3-, CCL5- and CCL8-induced cells migration and investigated whether the Ja …
9,238 results