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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1985 1
1987 1
1993 1
1998 1
1999 2
2000 3
2001 218
2002 675
2003 808
2004 933
2005 1097
2006 1162
2007 1112
2008 879
2009 807
2010 851
2011 796
2012 878
2013 788
2014 734
2015 718
2016 663
2017 661
2018 636
2019 270
2020 4
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13,321 results
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Page 1
A patent review of the ubiquitin ligase system: 2015-2018.
Li X, et al. Expert Opin Ther Pat 2018 - Review. PMID 30449221 Free PMC article.
Ubiquitin-proteasome system (UPS) has been validated as a novel anticancer drug target in the past 20 years. The UPS contains two distinct steps: ubiquitination of a substrate protein by ubiquitin activating enzyme (E1), ubiquitin conjugating enzyme (E2), and ubiquitin ligase (E3), and substrate degradation by the 26S proteasome complex. ...
Ubiquitin-proteasome system (UPS) has been validated as a novel anticancer drug target in the past 20 years. The UPS contains two dis
An E2-ubiquitin thioester-driven approach to identify substrates modified with ubiquitin and ubiquitin-like molecules.
Bakos G, et al. Nat Commun 2018. PMID 30429481 Free PMC article.
Covalent modifications of proteins with ubiquitin and ubiquitin-like molecules are instrumental to many biological processes. ...Finally, we perform E2~dID with SUMO in S. cerevisiae, showing that this approach can be easily adapted to other ubiquitin-like modifiers and experimental models....
Covalent modifications of proteins with ubiquitin and ubiquitin-like molecules are instrumental to many biological processes. …
Principles of Ubiquitin-Dependent Signaling.
Oh E, et al. Annu Rev Cell Dev Biol 2018 - Review. PMID 30110556
By combining multiple E3 ligases (writers), ubiquitin-binding effectors (readers), and de-ubiquitylases (erasers) with functionally distinct ubiquitylation tags, the ubiquitin system constitutes a powerful signaling network that is employed in similar ways from yeast to humans. Here, we discuss conserved principles of ubiquitin-dependent signaling that illustrate how this posttranslational modification shapes intracellular signaling networks to establish robust development and homeostasis throughout the eukaryotic kingdom....
By combining multiple E3 ligases (writers), ubiquitin-binding effectors (readers), and de-ubiquitylases (erasers) with functionally d …
p62-mediated phase separation at the intersection of the ubiquitin-proteasome system and autophagy.
Danieli A and Martens S. J Cell Sci 2018 - Review. PMID 30287680 Free article.
Misfolded proteins are normally degraded by the ubiquitin-proteasome system (UPS), and selective autophagy serves as a backup mechanism when the UPS is overloaded. ...
Misfolded proteins are normally degraded by the ubiquitin-proteasome system (UPS), and selective autophagy serves as a backup mechani …
Ubiquitin-Dependent and -Independent Roles of E3 Ligase RIPLET in Innate Immunity.
Cadena C, et al. Cell 2019. PMID 31006531 Free PMC article.
The conventional view posits that E3 ligases function primarily through conjugating ubiquitin (Ub) to their substrate molecules. ...
The conventional view posits that E3 ligases function primarily through conjugating ubiquitin (Ub) to their substrate molecules. ...
Ubiquitin-Proteasome Pathway and Muscle Atrophy.
Khalil R. Adv Exp Med Biol 2018 - Review. PMID 30390254
This process is carried out through an enzymatic cascade, which includes three groups of enzymes termed ubiquitin E1 (activating enzyme), ubiquitin E2 (conjugating enzyme), and ubiquitin E3 (ligase). There are several ways of ubiquitin conjugation driving to ubiquitination of specific proteins through ubiquitin-proteasome system (UPS). ...
This process is carried out through an enzymatic cascade, which includes three groups of enzymes termed ubiquitin E1 (activating enzy …
A Mycobacterium tuberculosis surface protein recruits ubiquitin to trigger host xenophagy.
Chai Q, et al. Nat Commun 2019. PMID 31036822 Free PMC article.
However, the exact mechanism by which host ubiquitin targets invaded microbes to trigger xenophagy remains obscure. Here we show that ubiquitin could recognize Mtb surface protein Rv1468c, a previously unidentified ubiquitin-binding protein containing a eukaryotic-like ubiquitin-associated (UBA) domain. The UBA-mediated direct binding of ubiquitin to, but not E3 ubiquitin ligases-mediated ubiquitination of, Rv1468c recruits autophagy receptor p62 to deliver mycobacteria into LC3-associated autophagosomes. ...
However, the exact mechanism by which host ubiquitin targets invaded microbes to trigger xenophagy remains obscure. Here we show that …
The Role of ATG16 in Autophagy and The Ubiquitin Proteasome System.
Xiong Q, et al. Cells 2018 - Review. PMID 30577509 Free PMC article.
Autophagy and the ubiquitin proteasome system (UPS) are the two major cellular degradation pathways, which are critical for the maintenance of cell homeostasis. ...
Autophagy and the ubiquitin proteasome system (UPS) are the two major cellular degradation pathways, which are critical for the maint …
Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing
Boland B, et al. Nat Rev Drug Discov 2018 - Review. PMID 30116051 Free PMC article.
Several other clearance pathways are also compromised in NDAs: chaperone-mediated autophagy, the ubiquitin-proteasome system, extracellular clearance by proteases and extrusion into the circulation via the blood-brain barrier and glymphatic system. ...
Several other clearance pathways are also compromised in NDAs: chaperone-mediated autophagy, the ubiquitin-proteasome system, extrace …
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