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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2000 1
2001 94
2002 285
2003 356
2004 363
2005 432
2006 496
2007 442
2008 361
2009 337
2010 366
2011 366
2012 386
2013 332
2014 309
2015 289
2016 271
2017 271
2018 254
2019 105
2020 2
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5,545 results
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Page 1
Ubiquitin modifications.
Swatek KN and Komander D. Cell Res 2016 - Review. PMID 27012465 Free PMC article.
While the number of distinctly modified ubiquitin species in cells is mind-boggling, much progress has been made to characterize the roles of distinct ubiquitin modifications, and many enzymes and receptors have been identified that create, recognize or remove these ubiquitin modifications. We here provide an overview of the various ubiquitin modifications present in cells, and highlight recent progress on ubiquitin chain biology. ...
While the number of distinctly modified ubiquitin species in cells is mind-boggling, much progress has been made to characterize the …
Building and decoding ubiquitin chains for mitophagy.
Harper JW, et al. Nat Rev Mol Cell Biol 2018 - Review. PMID 29358684
Owing to a combination of cell biological, structural and proteomic approaches, we are beginning to understand the mechanisms by which ubiquitin-dependent signals mark damaged mitochondria for mitophagy. This Review discusses the biochemical steps and regulatory mechanisms that promote the conjugation of ubiquitin to damaged mitochondria via the PTEN-induced putative kinase 1 (PINK1) and the E3 ubiquitin-protein ligase parkin and how ubiquitin chains promote autophagosomal capture. ...
Owing to a combination of cell biological, structural and proteomic approaches, we are beginning to understand the mechanisms by which ub
Ubiquitin-like Protein Conjugation: Structures, Chemistry, and Mechanism.
Cappadocia L and Lima CD. Chem Rev 2018 - Review. PMID 28234446 Free PMC article.
Ubiquitin-like proteins (Ubl's) are conjugated to target proteins or lipids to regulate their activity, stability, subcellular localization, or macromolecular interactions. Similar to ubiquitin, conjugation is achieved through a cascade of activities that are catalyzed by E1 activating enzymes, E2 conjugating enzymes, and E3 ligases. ...
Ubiquitin-like proteins (Ubl's) are conjugated to target proteins or lipids to regulate their activity, stability, subcellular locali
Linear ubiquitin chains: enzymes, mechanisms and biology.
Rittinger K and Ikeda F. Open Biol 2017 - Review. PMID 28446710 Free PMC article.
Its versatility is based on the ability of ubiquitin to form multiple types of polyubiquitin chains, which are recognized by specific ubiquitin receptors to induce the required cellular response. ...These chains are generated by a ubiquitin E3 ligase complex called the linear ubiquitin chain assembly complex (LUBAC) that is thus far the only E3 ligase capable of forming linear ubiquitin chains. ...
Its versatility is based on the ability of ubiquitin to form multiple types of polyubiquitin chains, which are recognized by specific …
The increasing complexity of the ubiquitin code.
Yau R and Rape M. Nat Cell Biol 2016 - Review. PMID 27230526
Substrate modifications range from a single ubiquitin molecule to complex polymeric chains, with different types of ubiquitylation often eliciting distinct outcomes. ...
Substrate modifications range from a single ubiquitin molecule to complex polymeric chains, with different types of ubiquitylation of …
Targeting the ubiquitin pathway for cancer treatment.
Liu J, et al. Biochim Biophys Acta 2015 - Review. PMID 25481052 Free PMC article.
In this process, the E3 ubiquitin ligases are responsible for targeting specific substrates (proteins) for ubiquitin-mediated degradation. ...Therefore, E3 ubiquitin ligases including the SCF types of ubiquitin ligases have recently evolved as promising therapeutic targets for the development of novel anti-cancer drugs. ...
In this process, the E3 ubiquitin ligases are responsible for targeting specific substrates (proteins) for ubiquitin-mediated …
New insights into the structure of PINK1 and the mechanism of ubiquitin phosphorylation.
Rasool S and Trempe JF. Crit Rev Biochem Mol Biol 2018 - Review. PMID 30238821
This gene encodes a protein kinase implicated in mitochondrial quality control via ubiquitin phosphorylation and activation of the E3 ubiquitin ligase Parkin. ...We critically assess the conformational changes taking place in ubiquitin and the Parkin ubiquitin-like domain in relation to its binding to PINK1. ...
This gene encodes a protein kinase implicated in mitochondrial quality control via ubiquitin phosphorylation and activation of the E3 …
UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites
Akimov V, et al. Nat Struct Mol Biol 2018. PMID 29967540
To enable delineation of protein ubiquitination at a site-specific level, we generated an antibody, denoted UbiSite, recognizing the C-terminal 13 amino acids of ubiquitin, which remain attached to modified peptides after proteolytic digestion with the endoproteinase LysC. Notably, UbiSite is specific to ubiquitin. Furthermore, besides ubiquitination on lysine residues, protein N-terminal ubiquitination is readily detected as well. ...
To enable delineation of protein ubiquitination at a site-specific level, we generated an antibody, denoted UbiSite, recognizing the C-termi …
Regulation of DNA double-strand break repair by ubiquitin and ubiquitin-like modifiers.
Schwertman P, et al. Nat Rev Mol Cell Biol 2016 - Review. PMID 27211488
Signalling by ubiquitin, SUMO and other ubiquitin-like modifiers (UBLs) orchestrates and regulates cellular responses to DSBs at multiple levels, often involving extensive crosstalk between these modifications. Recent findings have revealed compelling insights into the complex mechanisms by which ubiquitin and UBLs regulate protein interactions with DSB sites to promote accurate lesion repair and protection of genome integrity in mammalian cells. ...
Signalling by ubiquitin, SUMO and other ubiquitin-like modifiers (UBLs) orchestrates and regulates cellular responses to DSBs …
Ubiquitin signaling in immune responses.
Hu H and Sun SC. Cell Res 2016 - Review. PMID 27012466 Free PMC article.
Like phosphorylation, ubiquitination is a reversible reaction tightly controlled by the opposing actions of ubiquitin ligases and deubiquitinases. ...
Like phosphorylation, ubiquitination is a reversible reaction tightly controlled by the opposing actions of ubiquitin ligases and deu …
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