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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1950 2
1953 2
1955 3
1959 2
1960 1
1961 1
1962 3
1963 1
1964 5
1965 5
1966 9
1967 10
1968 7
1969 6
1970 3
1971 7
1972 4
1973 4
1974 6
1975 19
1976 28
1977 26
1978 38
1979 40
1980 51
1981 70
1982 70
1983 179
1984 224
1985 345
1986 451
1987 507
1988 625
1989 748
1990 834
1991 878
1992 994
1993 1016
1994 1095
1995 1174
1996 1222
1997 1300
1998 1317
1999 1384
2000 1474
2001 1522
2002 1630
2003 1712
2004 1869
2005 2028
2006 2117
2007 2312
2008 2488
2009 2760
2010 3042
2011 3424
2012 3833
2013 4173
2014 4630
2015 4931
2016 5858
2017 6217
2018 6418
2019 6985
2020 7349
2021 7022
2022 5923
2023 5223
2024 1819

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101,228 results

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Page 1
Baicalein increases cisplatin sensitivity of A549 lung adenocarcinoma cells via PI3K/Akt/NF-kappaB pathway.
Yu M, Qi B, Xiaoxiang W, Xu J, Liu X. Yu M, et al. Biomed Pharmacother. 2017 Jun;90:677-685. doi: 10.1016/j.biopha.2017.04.001. Epub 2017 Apr 14. Biomed Pharmacother. 2017. PMID: 28415048 Review.
Our study showed that baicalein significantly enhanced the chemosensitivity of cisplatin (CDDP) in vivo and in vitro. We found that A549/CDDP (resistant to CDDP) cells not only acquired epithelial-mesenchymal transition (EMT) phenotype, but also showed increased NF- …
Our study showed that baicalein significantly enhanced the chemosensitivity of cisplatin (CDDP) in vivo and in vitro. We found that A549
制备人脐静脉内皮细胞和人肺腺癌细胞融合细胞的新方法.
席 玉. 席 玉. Technol Cancer Res Treat. 2021 Jan-Dec;20:15330338211034260. doi: 10.1177/15330338211034260. Technol Cancer Res Treat. 2021. PMID: 34318732 Free PMC article.
METHODS: A549 cells were induced by ethyl methane sulfonate (EMS) and 8-azaguanine (8-AG) to get hypoxanthine guanine phosphoribosyl transferase (HGPRT) auxotrophic A549 cells. ...VE-cadherin and platelet endothelial cell adhesion molecule-1 (CD31) wer …
METHODS: A549 cells were induced by ethyl methane sulfonate (EMS) and 8-azaguanine (8-AG) to get hypoxanthine guanine phosphor …
Identification and validation of ferroptosis-related genes in lipopolysaccharide-induced acute lung injury.
Wang S, Song Y, Xu F, Liu H, Shen Y, Hu L, Fu Y, Zhu L. Wang S, et al. Cell Signal. 2023 Aug;108:110698. doi: 10.1016/j.cellsig.2023.110698. Epub 2023 May 5. Cell Signal. 2023. PMID: 37149072
In vitro, the upregulated mRNA levels of CXCL2, IL-6, SLC2A1, FTH1, TNFAIP3, and downregulated NQO1 and CAV1 in LPS-stimulated BEAS-2B and A549 cells were verified. CONCLUSION: We identified 86 potential ferroptosis-related genes of LPS-induced ALI through RNA-seq. …
In vitro, the upregulated mRNA levels of CXCL2, IL-6, SLC2A1, FTH1, TNFAIP3, and downregulated NQO1 and CAV1 in LPS-stimulated BEAS-2B and …
Increased expression of OPN contributes to idiopathic pulmonary fibrosis and indicates a poor prognosis.
Ji J, Zheng S, Liu Y, Xie T, Zhu X, Nie Y, Shen Y, Han X. Ji J, et al. J Transl Med. 2023 Sep 19;21(1):640. doi: 10.1186/s12967-023-04279-0. J Transl Med. 2023. PMID: 37726818 Free PMC article.
Bleomycin induced mouse pulmonary fibrosis model and OPN/OPN-biotin treated mouse model were established to investigate the role of OPN in mouse pulmonary fibrosis and the target cells of OPN. A549 cells and HBE cells were used to explore the mechanism …
Bleomycin induced mouse pulmonary fibrosis model and OPN/OPN-biotin treated mouse model were established to investigate the role of OPN in m …
Luteolin inhibits A549 cells proliferation and migration by down-regulating androgen receptors.
Li X, Tang Y, Liang P, Sun M, Li T, Shen Z, Sha S. Li X, et al. Eur J Med Res. 2023 Sep 16;28(1):353. doi: 10.1186/s40001-023-01302-4. Eur J Med Res. 2023. PMID: 37716981 Free PMC article.
METHODS: Molecular docking, network pharmacology methods and quantitative structure-activity relationship (QSAR) model were used to identify the active components of YQG and their possible mechanisms of action. Western blot analysis was used to measure AR expression in A549
METHODS: Molecular docking, network pharmacology methods and quantitative structure-activity relationship (QSAR) model were used to identify …
Effect of WISP1 on paraquat-induced EMT.
Liu J, Lv S, Ma W, Yang D, Zhang X. Liu J, et al. Toxicol In Vitro. 2023 Dec;93:105693. doi: 10.1016/j.tiv.2023.105693. Epub 2023 Sep 7. Toxicol In Vitro. 2023. PMID: 37689312 Free article.
RESULTS: With the increase of PQ concentration, the morphology of A549 cells was apparently changed, cell apoptosis and mortality were enhanced. ...Downregulation of WISP1 curbed morphology change and PQ-induced EMT in A549 cells. CONCLUSION: Knockdown …
RESULTS: With the increase of PQ concentration, the morphology of A549 cells was apparently changed, cell apoptosis and mortal …
Live-Cell-Templated Dynamic Combinatorial Chemistry.
Carbajo D, Pérez Y, Bujons J, Alfonso I. Carbajo D, et al. Angew Chem Int Ed Engl. 2020 Sep 21;59(39):17202-17206. doi: 10.1002/anie.202004745. Epub 2020 May 26. Angew Chem Int Ed Engl. 2020. PMID: 32348612
In order to do that, a chemical entity is used as template within a dynamic combinatorial library of interconverting species, so that the stronger binders are amplified due to the efficient interaction with the target. Here we employed whole A549 living cells as tem …
In order to do that, a chemical entity is used as template within a dynamic combinatorial library of interconverting species, so that the st …
Anti-cancer activity of benzoxazinone derivatives via targeting c-Myc G-quadruplex structure.
Jiang S, Awadasseid A, Narva S, Cao S, Tanaka Y, Wu Y, Fu W, Zhao X, Wei C, Zhang W. Jiang S, et al. Life Sci. 2020 Oct 1;258:118252. doi: 10.1016/j.lfs.2020.118252. Epub 2020 Aug 10. Life Sci. 2020. PMID: 32791149
AIMS: This study aimed to analyze the impact of four synthesized benzoxazinone derivatives as screening drugs on c-Myc-overexpressed cancer cells (H7402, HeLa, SK-RC-42, SGC7901, and A549) and to explore their interaction mechanisms in detail. ...KEY F …
AIMS: This study aimed to analyze the impact of four synthesized benzoxazinone derivatives as screening drugs on c-Myc-overexp …
Host factor TNK2 is required for influenza virus infection.
Zhou A, Zhang W, Wang B. Zhou A, et al. Genes Genomics. 2023 Jun;45(6):771-781. doi: 10.1007/s13258-023-01384-8. Epub 2023 May 3. Genes Genomics. 2023. PMID: 37133719
OBJECTIVE: Here we demonstrate the role of TNK2 in influenza virus infection. CRISPR/Cas9 induced TNK2 deletion in A549 cells. METHODS: CRISPR/Cas9-mediated deletion of TNK2. Western blotting and qPCR was used to measure the expression of TNK2 and other proteins. .. …
OBJECTIVE: Here we demonstrate the role of TNK2 in influenza virus infection. CRISPR/Cas9 induced TNK2 deletion in A549 cells. …
Indole-based alkaloids from Ophiocordyceps xuefengensis.
Qin Y, Zhou RR, Jin J, Cheng F, Shen BB, Zeng HL, Wan D, Zhong C, Xie J, Shu J, Shi SY, Zhang SH. Qin Y, et al. Phytochemistry. 2021 Jan;181:112536. doi: 10.1016/j.phytochem.2020.112536. Epub 2020 Nov 5. Phytochemistry. 2021. PMID: 33160226
Eleven of the isolates were tested for cytotoxicity against the U937, NB4, MCF-7, Hep G2, and A549 cancer cell lines. Two compounds exhibited moderate activities, with IC(50) values of 2.83-25.68 muM and 1.54-12.16 muM. Further pharmacological studies showed that these two …
Eleven of the isolates were tested for cytotoxicity against the U937, NB4, MCF-7, Hep G2, and A549 cancer cell lines. Two compounds e …
101,228 results
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