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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1989 1
1990 3
1991 2
1992 1
1993 4
1994 3
1996 7
1997 6
1998 18
1999 7
2000 10
2001 39
2002 53
2003 47
2004 39
2005 52
2006 62
2007 71
2008 81
2009 79
2010 82
2011 104
2012 93
2013 116
2014 92
2015 68
2016 89
2017 71
2018 118
2019 76
2020 2
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1,311 results
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Page 1
NKCC1 up-regulation contributes to early post-traumatic seizures and increased post-traumatic seizure susceptibility.
Wang F, et al. Brain Struct Funct 2017. PMID 27586142 Free PMC article.
Up-regulation of NKCC1 in neurons has been shown to be involved in neonatal seizures and in ammonia toxicity-induced seizures. ...Thus, TGFβ might be an important pathway involved in NKCC1 up-regulation after TBI. Our findings identify neuronal up-regulation of NKCC1 and its mediation by TGFβ, as a potential and important mechanism in the early post-traumatic seizures, and demonstrate the therapeutic potential of blocking this pathway....
Up-regulation of NKCC1 in neurons has been shown to be involved in neonatal seizures and in ammonia toxicity-induced seizures.
Genetic compensation induced by deleterious mutations but not gene knockdowns
Rossi A, et al. Nature 2015. PMID 26168398
The increasing use of reverse genetics in zebrafish, and other model systems, has revealed profound differences between the phenotypes caused by genetic mutations and those caused by gene knockdowns at many loci, an observation previously reported in mouse and Arabidopsis. ...
The increasing use of reverse genetics in zebrafish, and other model systems, has revealed profound differences between the phenotype …
Mechanisms of Hypoxic Up-Regulation of Versican Gene Expression in Macrophages.
Sotoodehnejadnematalahi F, et al. PLoS One 2015. PMID 26057378 Free PMC article.
Here we investigate the up-regulation of versican by hypoxia in primary human monocyte-derived macrophages (HMDM), and, intriguingly, show that versican mRNA is up-regulated much more highly (>600 fold) by long term hypoxia (5 days) than by 1 day of hypoxia (48 fold). ...Treatment of HMDM with two distinct specific inhibitors of Phosphoinositide 3-kinase (PI3K), LY290042 and wortmannin, significantly reduced induction of versican mRNA by hypoxia and provides evidence of a role for PI3K in hypoxic up-regulation of versican expression....
Here we investigate the up-regulation of versican by hypoxia in primary human monocyte-derived macrophages (HMDM), and, intrig …
Up-regulation of miR-155 contributes to TNF-mediated hepatocyte apoptosis in acute liver failure.
Zhang G, et al. Turk J Gastroenterol 2019. PMID 31061003 Free PMC article.
RESULTS: It was shown that miRNAs changed in the mice with ALF relating to hepatocytes apoptosis/necrosis; the selected miRNAs were confirmed with RT-PCR. miR-155 was up-regulated, but miR-698, -720, and -329 were down-regulated. Moreover, hepatic miR-155 was up-regulated at all-time points in the liver, but only at 7 h in spleen of mice with ALF. A significant correlation was observed between hepatic miR-155 and TNF/IL-6 in mice with ALF, which was supported by the findings in vitro showing up-regulated miR-155 in Raw264.7 cells and Hepa1-6 cells under LPS or D-GalN+TNF induction, respectively. ...
RESULTS: It was shown that miRNAs changed in the mice with ALF relating to hepatocytes apoptosis/necrosis; the selected miRNAs were confirme …
Evidence That Up-Regulation of MicroRNA-29 Contributes to Postnatal Body Growth Deceleration.
Kamran F, et al. Mol Endocrinol 2015. PMID 25866874 Free PMC article.
We previously showed that this decline in proliferation is driven in part by postnatal down-regulation of a large set of growth-promoting genes in multiple organs. ...Taken together, the findings suggest that up-regulation of miR-29 during juvenile life drives the down-regulation of multiple growth-promoting genes, thus contributing to physiological slowing and eventual cessation of body growth....
We previously showed that this decline in proliferation is driven in part by postnatal down-regulation of a large set of growth-promo …
Androgenic up-regulation of androgen receptor cDNA expression in androgen-independent prostate cancer cells.
Dai JL, et al. Steroids 1996. PMID 8883219
Although androgens down-regulate AR mRNA in most cell lines and tissues, including the prostate, up-regulation occurs in some tissues. ...In addition to up-regulation of AR mRNA, androgen induced comparable increases in AR protein levels in PC3 cells stably expressing an AR cDNA (PC3/AR). ...
Although androgens down-regulate AR mRNA in most cell lines and tissues, including the prostate, up-regulation occurs in some …
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