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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 8
1947 3
1948 7
1949 7
1950 17
1951 12
1952 10
1953 10
1954 7
1955 18
1956 9
1957 4
1958 7
1959 12
1960 10
1961 21
1962 22
1963 31
1964 48
1965 44
1966 43
1967 52
1968 63
1969 62
1970 59
1971 62
1972 62
1973 66
1974 61
1975 77
1976 63
1977 55
1978 40
1979 59
1980 62
1981 40
1982 36
1983 37
1984 51
1985 33
1986 42
1987 78
1988 63
1989 68
1990 83
1991 88
1992 90
1993 91
1994 89
1995 113
1996 128
1997 125
1998 143
1999 130
2000 124
2001 135
2002 165
2003 133
2004 152
2005 138
2006 140
2007 160
2008 132
2009 135
2010 155
2011 158
2012 154
2013 183
2014 195
2015 182
2016 174
2017 154
2018 165
2019 121
2020 3
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5,464 results
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Page 1
A role for bacterial urease in gut dysbiosis and Crohn's disease.
Ni J, et al. Sci Transl Med 2017. PMID 29141885 Free PMC article.
Inoculation of a conventional murine host (pretreated with antibiotics and polyethylene glycol) with commensal Escherichia coli engineered to express urease led to dysbiosis of the gut microbiota, resulting in a predominance of Proteobacteria species. ...A potential role for altered urease expression and nitrogen flux in the development of gut dysbiosis suggests that bacterial urease may be a potential therapeutic target for inflammatory bowel diseases....
Inoculation of a conventional murine host (pretreated with antibiotics and polyethylene glycol) with commensal Escherichia coli engineered t …
[Progress in bacterial urease complexes and their activation mechanisms].
Li X, et al. Sheng Wu Gong Cheng Xue Bao 2019 - Review. PMID 30806050 Chinese. Free article.
Urease decomposes urea to ammonia, and has application potential in agriculture and medical treatment. Urease proteins include structural proteins (UreA, UreB and UreC) and accessory proteins (UreD/UreH, UreE, UreF and UreG), each of them has its own unique role in urease maturation. ...We hope to provide theoretical basis for the regulation of urease activity and the development of urease inhibitors....
Urease decomposes urea to ammonia, and has application potential in agriculture and medical treatment. Urease proteins include
Urease activity according to the different inhibitors.
Gomes MP, et al. An Acad Bras Cienc 2018. PMID 30365707 Free article.
The activity of the urease enzyme was quantified by the methods proposed by May and Douglas (1976) and Witte and Medina-Escobar (2001). ...Zeolite did not influence the activity of the urease enzyme when analyzed by the May and Douglas method (1976)....
The activity of the urease enzyme was quantified by the methods proposed by May and Douglas (1976) and Witte and Medina-Escobar (2001 …
Noncatalytic Antioxidant Role for Helicobacter pylori Urease.
Schmalstig AA, et al. J Bacteriol 2018. PMID 29866802 Free PMC article.
The capacity of purified urease to protect whole cells via oxidant quenching was assessed by adding urease enzyme to nongrowing HOCl-exposed cells. ...To determine the capability of methionine sulfoxide reductase (Msr) to reduce oxidized Met residues in urease, purified H. pylori urease was exposed to HOCl and a previously described Msr peptide repair mixture was added. ...
The capacity of purified urease to protect whole cells via oxidant quenching was assessed by adding urease enzyme to nongrowin …
A patent update on therapeutic applications of urease inhibitors (2012-2018).
Hameed A, et al. Expert Opin Ther Pat 2019 - Review. PMID 30776929
Despite the large number of molecules known to have excellent urease inhibitory activity, there is an alarming lack of urease inhibitor drugs on the market. ...EXPERT OPINION: Urease is an important target to treat urease-related bacterial infections manifesting as gastric ulcers, urinary tract infections, and kidney stones. ...
Despite the large number of molecules known to have excellent urease inhibitory activity, there is an alarming lack of urease
Cryptococcus neoformans urease affects the outcome of intracellular pathogenesis by modulating phagolysosomal pH.
Fu MS, et al. PLoS Pathog 2018. PMID 29906292 Free PMC article.
Urease is a major virulence factor in C. neoformans but its role during macrophage interaction has not been characterized. Consequently, we analyzed the effect of urease on fungal-macrophage interaction using wild-type, urease-deficient and urease-complemented strains of C. neoformans. ...The production of urease was associated with increased phagolysosomal pH, which in turn reduced growth of urease-positive C. neoformans inside macrophages. ...
Urease is a major virulence factor in C. neoformans but its role during macrophage interaction has not been characterized. Consequent
Targeting Helicobacter pylori urease activity and maturation: In-cell high-throughput approach for drug discovery.
Tarsia C, et al. Biochim Biophys Acta Gen Subj 2018. PMID 30048738
Targeting urease represents a key strategy for drug design and H. pylori eradication. METHOD: Here, we describe a novel method to screen, directly in the cellular environment, urease inhibitors. A ureolytic Escherichia coli strain was engineered by cloning the entire urease operon in an expression plasmid and used to test in-cell urease inhibition with a high-throughput colorimetric assay. ...
Targeting urease represents a key strategy for drug design and H. pylori eradication. METHOD: Here, we describe a novel method to scr …
Inhibition of Helicobacter pylori and Its Associated Urease by Palmatine: Investigation on the Potential Mechanism.
Zhou JT, et al. PLoS One 2017. PMID 28045966 Free PMC article.
Pal was observed to significantly inhibit both H. pylori urease (HPU) and jack bean urease (JBU) in a dose-dependent manner, with IC50 values of 0.53 ± 0.01 mM and 0.03 ± 0.00 mM, respectively, as compared with acetohydroxamic acid, a well-known urease inhibitor (0.07 ± 0.01 mM for HPU and 0.02 ± 0.00 mM for JBU, respectively). ...Taken together, Pal was an effective inhibitor of H. pylori and its urease targeting the sulfhydryl groups, representing a promising candidate as novel urease inhibitor. ...
Pal was observed to significantly inhibit both H. pylori urease (HPU) and jack bean urease (JBU) in a dose-dependent manner, w …
Urease is an essential component of the acid response network of Staphylococcus aureus and is required for a persistent murine kidney infection.
Zhou C, et al. PLoS Pathog 2019. PMID 30608981 Free PMC article.
However, the function of urease in S. aureus niche colonization and nitrogen metabolism has not been extensively studied. We discovered that urease is essential for pH homeostasis and viability in urea-rich environments under weak acid stress. The regulation of urease transcription by CcpA, Agr, and CodY was identified in this study, implying a complex network that controls urease expression in response to changes in metabolic flux. ...
However, the function of urease in S. aureus niche colonization and nitrogen metabolism has not been extensively studied. We discover …
CeO(2-x) nanorods with intrinsic urease-like activity.
Korschelt K, et al. Nanoscale 2018. PMID 29961799
We show that CeO2-x nanorods (NRs) act as the first and efficient green urease mimic that catalyzes the hydrolysis of urea under ambient conditions with an activity (kcat = 9.58 × 101 s-1) about one order of magnitude lower than that of the native jack bean urease. ...CeO2-x NRs are stable against pH changes and even to the presence of transition metal ions like Cu2+, one of the strongest urease inhibitors. ...
We show that CeO2-x nanorods (NRs) act as the first and efficient green urease mimic that catalyzes the hydrolysis of urea under ambi …
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