A Randomized Trial of Shunting for Idiopathic Normal-Pressure Hydrocephalus.
Luciano MG, Williams MA, Hamilton MG, Katzen HL, Dasher NA, Moghekar A, Hua J, Malm J, Eklund A, Alpert Abel N, Raslan AM, Elder BD, Savage JJ, Barrow DL, Shahlaie K, Jensen H, Zwimpfer TJ, Wollett J, Hanley DF, Holubkov R; PENS Trial Investigators and the Adult Hydrocephalus Clinical Research Network.
Luciano MG, et al.
N Engl J Med. 2025 Dec 4;393(22):2198-2209. doi: 10.1056/NEJMoa2503109. Epub 2025 Sep 16.
N Engl J Med. 2025.
PMID: 40960253
Free PMC article.
Clinical Trial.
Secondary outcomes were the change at 3 months in the Tinetti scale total score (range, 0 to 28; lower scores indicate worse gait and balance), Montreal Cognitive Assessment (MoCA) score (range, 0 to 30; lower scores indicate worse cognition), and Overactive Bladder …
Secondary outcomes were the change at 3 months in the Tinetti scale total score (range, 0 to 28; lower scores indicate worse gait and balanc …