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Quoted phrase not found in phrase index: "Uveal Melanoma Metastatic in the Liver"
Page 1
Advances in the clinical management of uveal melanoma.
Carvajal RD, Sacco JJ, Jager MJ, Eschelman DJ, Olofsson Bagge R, Harbour JW, Chieng ND, Patel SP, Joshua AM, Piperno-Neumann S. Carvajal RD, et al. Nat Rev Clin Oncol. 2023 Feb;20(2):99-115. doi: 10.1038/s41571-022-00714-1. Epub 2023 Jan 4. Nat Rev Clin Oncol. 2023. PMID: 36600005 Review.
Until January 2022, no systemic therapy had received regulatory approval for patients with metastatic uveal melanoma, and these patients have historically had a dismal prognosis owing to the limited efficacy of the available treatments. ...In this Revi …
Until January 2022, no systemic therapy had received regulatory approval for patients with metastatic uveal melanoma, a …
Uveal melanoma.
Jager MJ, Shields CL, Cebulla CM, Abdel-Rahman MH, Grossniklaus HE, Stern MH, Carvajal RD, Belfort RN, Jia R, Shields JA, Damato BE. Jager MJ, et al. Nat Rev Dis Primers. 2020 Apr 9;6(1):24. doi: 10.1038/s41572-020-0158-0. Nat Rev Dis Primers. 2020. PMID: 32273508 Review.
Uveal melanoma (UM) is the most common primary intraocular malignancy in adults. UMs are usually initiated by a mutation in GNAQ or GNA11, unlike cutaneous melanomas, which usually harbour a BRAF or NRAS mutation. ...Ocular outcomes are best with small tumours not e …
Uveal melanoma (UM) is the most common primary intraocular malignancy in adults. UMs are usually initiated by a mutation in GN …
Metastatic uveal melanoma: The final frontier.
Rantala ES, Hernberg MM, Piperno-Neumann S, Grossniklaus HE, Kivelä TT. Rantala ES, et al. Prog Retin Eye Res. 2022 Sep;90:101041. doi: 10.1016/j.preteyeres.2022.101041. Epub 2022 Jan 6. Prog Retin Eye Res. 2022. PMID: 34999237 Free article. Review.
The final frontier in conquering uveal melanoma lies in solving these issues to cure metastatic disease. Most studies on metastatic uveal melanoma are small, uncontrolled, retrospective, and do not report staging. ...Promoting dormancy of …
The final frontier in conquering uveal melanoma lies in solving these issues to cure metastatic disease. Most studies o …
Uveal melanoma: In the era of new treatments.
Wespiser M, Neidhardt E, Negrier S. Wespiser M, et al. Cancer Treat Rev. 2023 Sep;119:102599. doi: 10.1016/j.ctrv.2023.102599. Epub 2023 Jul 7. Cancer Treat Rev. 2023. PMID: 37473516 Review.
Uveal melanoma (UM), also known as choroidal melanoma, is the leading adult intraocular tumor worldwide, affecting mainly Caucasian populations. ...Despite optimal management, half of the patients will become metastatic, with liver involvement in 90% o …
Uveal melanoma (UM), also known as choroidal melanoma, is the leading adult intraocular tumor worldwide, affecting mainly Cauc …
Metastatic disease from uveal melanoma: treatment options and future prospects.
Carvajal RD, Schwartz GK, Tezel T, Marr B, Francis JH, Nathan PD. Carvajal RD, et al. Br J Ophthalmol. 2017 Jan;101(1):38-44. doi: 10.1136/bjophthalmol-2016-309034. Epub 2016 Aug 29. Br J Ophthalmol. 2017. PMID: 27574175 Free PMC article. Review.
Uveal melanoma represents 85% of all ocular melanomas and up to 50% of patients develop metastatic disease. ...Uveal and cutaneous melanomas are intrinsically different diseases and so dedicated management strategies and therapies for uveal melanoma …
Uveal melanoma represents 85% of all ocular melanomas and up to 50% of patients develop metastatic disease. ...Uveal an …
Tebentafusp for the treatment of HLA-A*02:01-positive adult patients with unresectable or metastatic uveal melanoma.
Chen LN, Carvajal RD. Chen LN, et al. Expert Rev Anticancer Ther. 2022 Oct;22(10):1017-1027. doi: 10.1080/14737140.2022.2124971. Epub 2022 Sep 19. Expert Rev Anticancer Ther. 2022. PMID: 36102132 Free PMC article. Review.
INTRODUCTION: Metastatic uveal melanoma is associated with poor prognosis and few treatment options. Tebentafusp recently became the first FDA-approved agent for metastatic uveal melanoma. ...We also review promising early-phase tr …
INTRODUCTION: Metastatic uveal melanoma is associated with poor prognosis and few treatment options. Tebentafusp …
ITGB2-ICAM1 axis promotes liver metastasis in BAP1-mutated uveal melanoma with retained hypoxia and ECM signatures.
Li J, Cao D, Jiang L, Zheng Y, Shao S, Zhuang A, Xiang D. Li J, et al. Cell Oncol (Dordr). 2024 Jun;47(3):951-965. doi: 10.1007/s13402-023-00908-4. Epub 2023 Dec 27. Cell Oncol (Dordr). 2024. PMID: 38150154
Then, an immune-competent mouse liver metastatic model was used to explore the role of ITGB2-ICAM1 in BAP1-associated UM metastasis. ...High expression of either ITGB2 or ICAM1 was a worse prognostic indicator. Using an immune-competent mouse liver …
Then, an immune-competent mouse liver metastatic model was used to explore the role of ITGB2-ICAM1 in BAP1-associated UM metas …
LKB1-SIK2 loss drives uveal melanoma proliferation and hypersensitivity to SLC8A1 and ROS inhibition.
Proteau S, Krossa I, Husser C, Guéguinou M, Sella F, Bille K, Irondelle M, Dalmasso M, Barouillet T, Cheli Y, Pisibon C, Arrighi N, Nahon-Estève S, Martel A, Gastaud L, Lassalle S, Mignen O, Brest P, Mazure NM, Bost F, Baillif S, Landreville S, Turcotte S, Hasson D, Carcamo S, Vandier C, Bernstein E, Yvan-Charvet L, Levesque MP, Ballotti R, Bertolotto C, Strub T. Proteau S, et al. EMBO Mol Med. 2023 Dec 7;15(12):e17719. doi: 10.15252/emmm.202317719. Epub 2023 Nov 15. EMBO Mol Med. 2023. PMID: 37966164 Free PMC article.
We further demonstrate that combination of an SLC8A1 inhibitor and a mitochondria-targeted antioxidant promotes enhanced cell death efficacy in LKB1- and SIK2-negative uveal melanoma cells compared to control cells. Our study also identified an LKB1-loss gene signat …
We further demonstrate that combination of an SLC8A1 inhibitor and a mitochondria-targeted antioxidant promotes enhanced cell death efficacy …
Spliceosome Mutations in Uveal Melanoma.
Nguyen JQN, Drabarek W, Yavuzyigitoglu S, Medico Salsench E, Verdijk RM, Naus NC, de Klein A, Kiliç E, Brosens E. Nguyen JQN, et al. Int J Mol Sci. 2020 Dec 15;21(24):9546. doi: 10.3390/ijms21249546. Int J Mol Sci. 2020. PMID: 33333932 Free PMC article. Review.
Uveal melanoma (UM) is the most common primary intraocular malignancy of the eye. It has a high metastatic potential and mainly spreads to the liver. Genetics play a vital role in tumor classification and prognostication of UM metastatic …
Uveal melanoma (UM) is the most common primary intraocular malignancy of the eye. It has a high metastatic potential an …
Recent Advances in Molecular and Genetic Research on Uveal Melanoma.
Fuentes-Rodriguez A, Mitchell A, Guérin SL, Landreville S. Fuentes-Rodriguez A, et al. Cells. 2024 Jun 12;13(12):1023. doi: 10.3390/cells13121023. Cells. 2024. PMID: 38920653 Free PMC article. Review.
Uveal melanoma (UM), a distinct subtype of melanoma, presents unique challenges in its clinical management due to its complex molecular landscape and tendency for liver metastasis. ...This review identifies challenges in UM research, such as the limited treat …
Uveal melanoma (UM), a distinct subtype of melanoma, presents unique challenges in its clinical management due to its complex …
273 results