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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1974 1
1976 2
1978 2
1979 1
1982 1
1988 2
1990 2
1991 1
1992 1
1993 2
1994 70
1995 2
1996 8
1997 12
1998 9
1999 58
2000 1108
2001 2332
2002 2878
2003 6449
2004 7334
2005 5187
2006 4643
2007 5319
2008 5533
2009 5878
2010 6719
2011 7358
2012 7709
2013 7385
2014 7382
2015 7185
2016 7063
2017 7075
2018 6493
2019 2855
2020 52
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98,908 results
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Page 1
Validation of in vitro methods for human cytochrome P450 enzyme induction: Outcome of a multi-laboratory study.
Bernasconi C, et al. Toxicol In Vitro 2019. PMID 31158489 Free PMC article.
This paper summarises the results of a multi-laboratory validation study of two in vitro methods that assess the potential of chemicals to induce cytochrome P450 (CYP) enzyme activity, in particular CYP1A2, CYP2B6, and CYP3A4. ...The validation study was coordinated by the European Union Reference Laboratory for Alternatives to Animal Testing of the European Commission's Joint Research Centre and involved a ring trial among six laboratories. ...
This paper summarises the results of a multi-laboratory validation study of two in vitro methods that assess the potential of …
Fit-for-Purpose Validation of a Ligand Binding Assay for Toxicokinetic Study Using Mouse Serial Sampling.
Zhu L, et al. Pharm Res 2019. PMID 31654236
The method validation evaluated assay characteristics including accuracy and precision, influence of sample processing on drug quantitation, whole blood matrix selectivity, dilution linearity and the stability of the drug in the study sample matrix. ...The experience shared in this study could serve as a model process for bioanalytical method validation when capillary microsampling is used....
The method validation evaluated assay characteristics including accuracy and precision, influence of sample processing on drug quanti …
A validation study of the Eurostat harmonised European time use study (HETUS) diary using wearable technology.
Harms T, et al. BMC Public Health 2019. PMID 31159770 Free PMC article.
METHODS: Participants (n = 148) were asked to complete a single-day self-report paper time-use diary designed for use in the Harmonised European Time Use Study (HETUS), while simultaneously wearing a camera that continuously recorded images of their activities, and an accelerometer tracking physical movement. ...
METHODS: Participants (n = 148) were asked to complete a single-day self-report paper time-use diary designed for use in the Harmonised Euro …
Validation of cellular tests for Lyme borreliosis (VICTORY) study.
van de Schoor FR, et al. BMC Infect Dis 2019. PMID 31429716 Free PMC article.
METHODS: VICTORY is a prospective two-gate case-control study. We strive to include 150 patients who meet the European case definitions for either localized or disseminated LB. ...DISCUSSION: This article describes the background and design of the VICTORY study protocol. The findings of our study will help to better appreciate the utility of cellular tests in the diagnosis of Lyme borreliosis. ...
METHODS: VICTORY is a prospective two-gate case-control study. We strive to include 150 patients who meet the European case definitio …
An artificial intelligence-enabled ECG algorithm for the identification of patients with atrial fibrillation during sinus rhythm: a retrospective analysis of outcome prediction
Attia ZI, et al. Lancet 2019. PMID 31378392
We allocated ECGs to the training, internal validation, and testing datasets in a 7:1:2 ratio. We calculated the area under the curve (AUC) of the receiver operatoring characteristic curve for the internal validation dataset to select a probability threshold, which we applied to the testing dataset. ...Including all ECGs acquired during the first month of each patient's window of interest (ie, the study start date or 31 days before the first recorded atrial fibrillation ECG) increased the AUC to 0·90 (0·90-0·91), sensitivity to 82·3% (80·9-83·6), specificity to 83·4% (83·0-83·8), F1 score to 45·4% (44·2-46·5), and overall accuracy to 83·3% (83·0-83·7). ...
We allocated ECGs to the training, internal validation, and testing datasets in a 7:1:2 ratio. We calculated the area under the curve …
A validation study of questionnaire towards mobile based health applications in uncontrolled diabetic population of India (South).
Ashok Kumar M and Shanmugasundaram P. Diabetes Metab Syndr 2019. PMID 31235144
OBJECTIVE: This study was designed to develop and validate a questionnaire to assess knowledge, attitude and practice of uncontrolled diabetic patients towards mobile based health applications. METHODS: A Cross Sectional study was designed and enrolled 78 adult uncontrolled diabetic (≥18 years old DM type 2)patients and clinically validated questionnaire was examined for internal consistency, reproducibility, convergent and discriminant validity using Cronbach's alpha, intra class correlation and CITC scores respectively. ...
OBJECTIVE: This study was designed to develop and validate a questionnaire to assess knowledge, attitude and practice of uncontrolled …
Development and validation of a nomogram for osteosarcoma-specific survival: A population-based study.
Zhang J, et al. Medicine (Baltimore) 2019. PMID 31169737 Free PMC article.
This study aimed to establish a comprehensive prognostic system for osteosarcoma based on a large population database with high quality.The Surveillance, Epidemiology, and End Results (SEER) Program database was used to identify patients with osteosarcoma from 1973 to 2015. ...
This study aimed to establish a comprehensive prognostic system for osteosarcoma based on a large population database with high quali …
Multi-laboratory Validation Study of the Vitrigel-Eye Irritancy Test Method as an Alternative to In Vivo Eye Irritation Testing.
Kojima H, et al. Altern Lab Anim 2019. PMID 31838865
The current study was conducted in order to assess the reliability and relevance of the Vitrigel-EIT method at three participating laboratories by determining the method's within-laboratory reproducibility and between-laboratory reproducibility, as well as its capacity for distinguishing non-irritants from irritants in a bottom-up approach. ...
The current study was conducted in order to assess the reliability and relevance of the Vitrigel-EIT method at three participating la …
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