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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1998 1
2000 8
2001 8
2002 22
2003 264
2004 602
2005 619
2006 656
2007 696
2008 745
2009 734
2010 756
2011 755
2012 840
2013 773
2014 784
2015 753
2016 705
2017 573
2018 521
2019 247
2020 3
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9,636 results
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Page 1
Vascular endothelial growth factor: a neurovascular target in neurological diseases.
Lange C, et al. Nat Rev Neurol 2016 - Review. PMID 27364743
The archetypal vascular endothelial growth factor, VEGF, arose in evolution as a signal affecting neural cells, but was later co-opted by blood vessels to regulate vascular function. ...On the one hand, VEGF is neuroprotective, through direct effects on neural cells and their progenitors and indirect effects on brain perfusion. ...
The archetypal vascular endothelial growth factor, VEGF, arose in evolution as a signal affecting neural cells, but was …
The roles of vascular endothelial growth factor in bone repair and regeneration.
Hu K and Olsen BR. Bone 2016 - Review. PMID 27353702 Free PMC article.
Vascular endothelial growth factor-A (VEGF) is one of the most important growth factors for regulation of vascular development and angiogenesis. ...This review (i) summarizes the roles of VEGF at different stages of bone repair, including the phases of inflammation, endochondral ossification, intramembranous ossification during callus formation and bone remodeling; (ii) discusses different mechanisms underlying the effects of VEGF on osteoblast function, including paracrine, autocrine and intracrine signaling during bone repair; (iii) summarizes the role of VEGF in the bone regenerative procedure, distraction osteogenesis; and (iv) reviews evidence for the effects of VEGF in the context of repair and regeneration techniques involving the use of scaffolds, skeletal stem cells and growth factors....
Vascular endothelial growth factor-A (VEGF) is one of the most important growth factors for regulation of vascular deve
Vascular endothelial growth factor biology for regenerative angiogenesis.
Uccelli A, et al. Swiss Med Wkly 2019 - Review. PMID 30685867 Free article.
Vascular endothelial growth factor-A (VEGF) is the fundamental regulator of vascular growth and the key target of therapeutic angiogenesis approaches. However, first-generation clinical trials of VEGF gene therapy have been disappointing, and a clear clinical benefit has yet to be established. ...
Vascular endothelial growth factor-A (VEGF) is the fundamental regulator of vascular growth and the key target of thera
Vascular Endothelial Growth Factor Enhances Compensatory Lung Growth in Piglets.
Dao DT, et al. Surgery 2018. PMID 30193736 Free PMC article.
For pharmacokinetic studies, vascular endothelial growth factor was infused via a central venous catheter, with plasma vascular endothelial growth factor levels measured at various time points. ...CONCLUSION: Vascular endothelial growth factor enhanced alveolar growth in neonatal piglets after unilateral pneumonectomy....
For pharmacokinetic studies, vascular endothelial growth factor was infused via a central venous catheter, with plasma vasc
The role of vascular endothelial growth factor in pulmonary arterial hypertension. The angiogenesis paradox.
Voelkel NF and Gomez-Arroyo J. Am J Respir Cell Mol Biol 2014 - Review. PMID 24932885
PAH is widely considered a proangiogenic disease; however, the role of angiogenic factors, such as the vascular endothelial growth factor (VEGF) and its receptors, in the pathobiology of PAH remains incompletely understood. ...Furthermore, we provide a cogent explanation for the paradox of VEGF receptor blockade-induced pulmonary hypertension that characterizes the SU5416-hypoxia rat model of PAH, and attempt to translate the knowledge gained from the experimental model to the human disease by postulating the potential role of endogenous (SU5416-like) VEGF inhibitors. ...
PAH is widely considered a proangiogenic disease; however, the role of angiogenic factors, such as the vascular endothelial gr …
VEGF in Signaling and Disease: Beyond Discovery and Development
Apte RS, et al. Cell 2019 - Review. PMID 30849371 Free PMC article.
The discovery of vascular endothelial-derived growth factor (VEGF) has revolutionized our understanding of vasculogenesis and angiogenesis during development and physiological homeostasis. ...It is also an elegant example of how agnostic discovery and can transform our understanding of human disease. This review will highlight critical nodal points in VEGF biology, including recent developments in immunotherapy for cancer and multitarget approaches in neovascular eye disease....
The discovery of vascular endothelial-derived growth factor (VEGF) has revolutionized our understanding of vasculogenesis and …
Anti-angiogenic isoform of vascular endothelial growth factor-A in cardiovascular and renal disease.
Kikuchi R, et al. Adv Clin Chem 2019 - Review. PMID 30612603
Vascular endothelial growth factor-A (VEGF-A) is a major regulator of angiogenesis and vessel permeability, and is associated with CVD and CKD. ...Proximal splicing that includes an exon 8a sequence results in pro-angiogenic VEGF-A(165)a, whereas distal splicing inclusive of exon 8b yields the anti-angiogenic isoform of VEGF-A (VEGF-A(165)b). ...
Vascular endothelial growth factor-A (VEGF-A) is a major regulator of angiogenesis and vessel permeability, and is associated
The Role of Vascular Endothelial Growth Factor in Systemic Sclerosis.
Flower VA, et al. Curr Rheumatol Rev 2019 - Review. PMID 30091416
The present review shall examine the role of Vascular Endothelial Growth Factor (VEGF) in SSc pathogenesis. We shall outline potential mechanisms whereby differential Vascular Endothelial Growth Factor-A (VEGF-A) isoform expression (through conventional and alternative VEGF-A splicing,) may influence the relevant burden of vasculopathy and fibrosis offering novel insight into clinical heterogeneity and disease progression in SSc. Emerging therapeutic approaches targeting VEGF signaling pathways might play an important role in the management of SSc, and differential VEGF-A splice isoform expression may provide a tool for personalized medicine approaches to disease management....
The present review shall examine the role of Vascular Endothelial Growth Factor (VEGF) in SSc pathogenesis. We shall ou …
Expression of vascular endothelial growth factor (VEGF) in equine sarcoid.
Martano M, et al. BMC Vet Res 2018. PMID 30176852 Free PMC article.
In order to gain new insights into equine sarcoid development, we have evaluated, in 25 equine sarcoids, by immunohistochemistry and western blotting analysis, the expression levels of VEGF, Ki67 and bcl-2. ...CONCLUSIONS: This study has provided evidence that in equine sarcoid: VEGF was strongly expressed; the increased number of vessels was not associated with their complete maturation, probably leading to a hypoxic condition, which could increase VEGF synthesis; the levels of sarcoid fibroblasts proliferation were very low. ...
In order to gain new insights into equine sarcoid development, we have evaluated, in 25 equine sarcoids, by immunohisto …
Transient Overexpression of Vascular Endothelial Growth Factor A in Adipose Tissue Promotes Energy Expenditure via Activation of the Sympathetic Nervous System.
Zhao Y, et al. Mol Cell Biol 2018. Among authors: Eckel-Mahan K. PMID 30126894 Free PMC article.
Adipose-derived vascular endothelial growth factor A (VEGF-A) stimulates functional blood vessel formation in obese fat pads, which in turn facilitates healthy expansion of the adipose tissue. ...As a result, the adipose tissue exhibited increased lipolysis, browning, and energy expenditure. Importantly, all of these effects were abolished upon treatment with the β3-adrenoceptor antagonist SR59230A. ...
Adipose-derived vascular endothelial growth factor A (VEGF-A) stimulates functional blood vessel formation in obese fat pads, …
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