This Future Research Needs (FRN) report is based on a draft Agency for Healthcare Research and Quality comparative effectiveness review titled Interventions for Adolescents and Young Adults with autism spectrum disorder. The purpose of the review was to synthesize recent research focused on interventions for adolescents and young adults between the ages of 13 and 30 with autism spectrum disorder (ASD; autistic disorder, Asperger’s syndrome, pervasive developmental disorder–not otherwise specified). We addressed questions related to: the effectiveness of therapies targeting core symptoms of ASD (impairments in communication, social interaction, and behavior); common medical or mental health comorbidities, including associated symptoms such as irritability; the process of transitioning to adulthood; and family outcomes. The draft review is based on literature searches that were executed between September 2010 and December 2011. The publication of the final review is expected for August 2012.