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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 8
1946 38
1947 49
1948 28
1949 28
1950 42
1951 77
1952 75
1953 76
1954 93
1955 107
1956 119
1957 120
1958 101
1959 94
1960 87
1961 106
1962 75
1963 116
1964 167
1965 186
1966 162
1967 239
1968 254
1969 256
1970 247
1971 238
1972 284
1973 294
1974 289
1975 350
1976 246
1977 248
1978 260
1979 220
1980 213
1981 204
1982 230
1983 343
1984 411
1985 432
1986 388
1987 454
1988 433
1989 537
1990 646
1991 661
1992 745
1993 883
1994 879
1995 869
1996 863
1997 940
1998 1074
1999 1081
2000 1311
2001 1337
2002 1432
2003 1474
2004 1333
2005 1624
2006 1623
2007 1691
2008 1741
2009 1953
2010 1979
2011 2044
2012 1940
2013 1911
2014 2081
2015 2071
2016 2142
2017 2299
2018 2379
2019 1316
2020 32
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49,967 results
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Page 1
Evolution of bacterial virulence.
Diard M and Hardt WD. FEMS Microbiol Rev 2017 - Review. PMID 28531298
Two schools of thought have taken quite different directions to decipher the underlying principles of bacterial virulence. While molecular infection biology is focusing on the basic mechanisms of the pathogen-host interaction, evolution biology takes virulence as one of several parameters affecting pathogen spread in a host population. We review both approaches and discuss how they can complement each other in order to obtain a comprehensive understanding of bacterial virulence, its emergence, maintenance and evolution....
Two schools of thought have taken quite different directions to decipher the underlying principles of bacterial virulence. While mole …
Going around in circles: virulence plasmids in enteric pathogens.
Pilla G and Tang CM. Nat Rev Microbiol 2018 - Review. PMID 29855597
Virulence plasmids are usually large (>40 kb) low copy elements and encode genes that promote host-pathogen interactions. Although virulence plasmids provide advantages to bacteria in specific conditions, they often impose fitness costs on their host. ...We contrast these plasmids with those that are routinely used in the laboratory and outline the mechanisms by which virulence plasmids are maintained in bacterial populations. ...
Virulence plasmids are usually large (>40 kb) low copy elements and encode genes that promote host-pathogen interactions. Although
Targeting virulence: a new paradigm for antimicrobial therapy.
Clatworthy AE, et al. Nat Chem Biol 2007 - Review. PMID 17710100
Rather than focusing on therapeutics that target in vitro viability, much like conventional antibiotics, an alternative approach is to target functions essential for infection, such as virulence factors required to cause host damage and disease. ...We review new approaches to targeting virulence, discuss their advantages and disadvantages, and propose that in addition to targeting virulence, new antimicrobial development strategies should be expanded to include targeting bacterial gene functions that are essential for in vivo viability. ...
Rather than focusing on therapeutics that target in vitro viability, much like conventional antibiotics, an alternative approach is to targe …
Exploiting CRISPR-Cas nucleases to produce sequence-specific antimicrobials
Bikard D, et al. Nat Biotechnol 2014. PMID 25282355 Free PMC article.
We show that Cas9, reprogrammed to target virulence genes, kills virulent, but not avirulent, Staphylococcus aureus. Reprogramming the nuclease to target antibiotic resistance genes destroys staphylococcal plasmids that harbor antibiotic resistance genes and immunizes avirulent staphylococci to prevent the spread of plasmid-borne resistance genes. ...
We show that Cas9, reprogrammed to target virulence genes, kills virulent, but not avirulent, Staphylococcus aureus. Reprogramming th …
Regulation of virulence: the rise and fall of gastrointestinal pathogens.
Kitamoto S, et al. J Gastroenterol 2016 - Review. PMID 26553054 Free PMC article.
Pathogens utilize a wide array of virulence factors to outcompete their commensal rivals in the gut. However, since the expression of virulence factors is costly to maintain and reduces bacterial fitness, pathogens need to regulate their virulence properly in order to maximize their fitness. ...Here, we will review the dynamics of virulence and its role in infection....
Pathogens utilize a wide array of virulence factors to outcompete their commensal rivals in the gut. However, since the expression of …
[Salmonella pathogenicity islands]
Sırıken B. Mikrobiyol Bul 2013 - Review. PMID 23390917 Turkish. Free article.
The responsible virulence genes for invasion, survival, and extraintestinal spread are located in Salmonella pathogenicity islands (SPIs). ...In addition SPIs, Sigma ss (RpoS) factors and adaptive acid tolerance response (ATR) are the other two important virulence factors. ...
The responsible virulence genes for invasion, survival, and extraintestinal spread are located in Salmonella pathogenicity islands (S …
Pathogenesis of Staphylococcus aureus Bloodstream Infections
Thomer L, et al. Annu Rev Pathol 2016 - Review. PMID 26925499 Free PMC article.
The secretion of coagulases, proteins that associate with and activate the host hemostatic factor prothrombin, and the bacterial surface display of agglutinins, proteins that bind polymerized fibrin, are key virulence strategies for the pathogenesis of S. aureus bloodstream infections, which culminate in the establishment of abscess lesions. ...
The secretion of coagulases, proteins that associate with and activate the host hemostatic factor prothrombin, and the bacterial surface dis …
Sclerotinia sclerotiorum: An Evaluation of Virulence Theories.
Xu L, et al. Annu Rev Phytopathol 2018 - Review. PMID 29958073
Oxalic acid production in Sclerotinia sclerotiorum has long been associated with virulence. Research involving UV-induced, genetically undefined mutants that concomitantly lost oxalate accumulation, sclerotial formation, and pathogenicity supported the conclusion that oxalate is an essential pathogenicity determinant of S. sclerotiorum. ...Critical evaluation of available evidence showed that the UV-induced mutants harbored previously unrecognized confounding genetic defects in saprophytic growth and pH responsiveness, warranting reevaluation of the conclusions about virulence based on the UV-induced mutants. ...
Oxalic acid production in Sclerotinia sclerotiorum has long been associated with virulence. Research involving UV-induced, geneticall …
Virulence Structure Within Populations of Pseudoperonospora cubensis in the United States.
Thomas A, et al. Phytopathology 2017. PMID 28402210 Free article.
Virulence within the pathogen population was expressed based on virulence factors, virulence phenotypes, and virulence complexity. The number of virulence factors ranged from two to eight, indicating a complex virulence structure, with 77% of the isolates having five to eight virulence factors. ...
Virulence within the pathogen population was expressed based on virulence factors, virulence phenotypes, and virulen
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