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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1947 1
1949 2
1950 4
1951 2
1952 8
1953 2
1954 1
1955 3
1956 6
1957 3
1958 3
1959 1
1960 3
1961 3
1962 3
1963 3
1964 5
1965 1
1976 1
1979 1
1980 2
1981 13
1982 14
1983 17
1984 18
1985 24
1986 22
1987 41
1988 36
1989 49
1990 68
1991 65
1992 78
1993 90
1994 105
1995 82
1996 73
1997 61
1998 69
1999 64
2000 71
2001 88
2002 130
2003 313
2004 359
2005 437
2006 585
2007 662
2008 829
2009 1117
2010 1306
2011 1467
2012 1583
2013 1525
2014 1395
2015 1358
2016 1382
2017 1365
2018 1339
2019 801
2020 17
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17,004 results
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Page 1
Coagulase-Negative Staphylococci Pathogenomics
Argemi X, et al. Int J Mol Sci 2019 - Review. PMID 30862021 Free PMC article.
Several studies have investigated the molecular basis for this emergence and identified multiple putative virulence factors with regards to Staphylococcus aureus pathogenicity. In the last decade, numerous CoNS whole-genome sequences have been released, leading to the identification of numerous putative virulence factors. ...
Several studies have investigated the molecular basis for this emergence and identified multiple putative virulence factors with rega …
Virulence Factors Produced by Staphylococcus aureus Biofilms Have a Moonlighting Function Contributing to Biofilm Integrity.
Graf AC, et al. Mol Cell Proteomics 2019. PMID 30850421 Free PMC article.
Our analyses revealed the expression of many pathogenicity factors within S. aureus biofilms as indicated by a high abundance of capsule biosynthesis proteins along with various secreted virulence factors, including hemolysins, leukotoxins, and lipases as a part of the ECM. The activity of ECM virulence factors was confirmed in a hemolysis assay and a Galleria mellonella pathogenicity model. In addition, we uncovered a so far unacknowledged moonlighting function of secreted virulence factors and ribosomal proteins trapped in the ECM: namely their contribution to biofilm integrity. ...
Our analyses revealed the expression of many pathogenicity factors within S. aureus biofilms as indicated by a high abundance of capsule bio …
Natural Products That Target Virulence Factors in Antibiotic-Resistant Staphylococcus aureus.
Wu SC, et al. J Agric Food Chem 2019 - Review. PMID 31702908
Plants and microorganisms are not only important food and medicinal resources but also serve as sources for the discovery of natural products that target bacterial virulence factors. This review discusses the mechanisms of the major virulence factors of S. aureus, including the accessory gene regulator quorum-sensing system, bacterial biofilm formation, α-hemolysin, sortase A, and staphyloxanthin. ...
Plants and microorganisms are not only important food and medicinal resources but also serve as sources for the discovery of natural product …
Candida auris-the growing menace to global health
Lone SA and Ahmad A. Mycoses 2019 - Review. PMID 30773703
In this review, we discussed the nine-year-old history of C. auris-its trends in global emergence, epidemiological relatedness, isolation, mortality, associated risk factors, virulence factors, drug resistance and susceptibility testing, diagnostic challenges, microbiological characteristics, therapeutic options and infection prevention and control associated with this pathogen....
In this review, we discussed the nine-year-old history of C. auris-its trends in global emergence, epidemiological relatedness, isolation, m …
Helicobacter pylori virulence genes.
Šterbenc A, et al. World J Gastroenterol 2019 - Review. PMID 31543679 Free PMC article.
The pathogenesis of H. pylori infection and disease outcome is thus thought to be mediated by an intricate interplay between host, environmental and bacterial virulence factors. ...Numerous studies have focused on the prevalence and role of putative H. pylori virulence genes in disease pathogenesis. While several virulence factors with various functions have been identified, disease associations appear to be less evident, especially among different study populations. ...
The pathogenesis of H. pylori infection and disease outcome is thus thought to be mediated by an intricate interplay between host, environme …
Natural quorum sensing inhibitors effectively downregulate gene expression of Pseudomonas aeruginosa virulence factors.
Ahmed SAKS, et al. Appl Microbiol Biotechnol 2019. PMID 30852658 Free PMC article.
At present, anti-virulence drugs are being considered as potential therapeutic alternatives and/or adjuvants to currently failing antibiotics. ...The QSIs did not completely inhibit virulence factor expression and production but their administration significantly lowered the virulence phenotypes at both the transcriptional and extracellular levels. ...
At present, anti-virulence drugs are being considered as potential therapeutic alternatives and/or adjuvants to currently failing ant …
Screen for fitness and virulence factors of Francisella sp. strain W12-1067 using amoebae.
Köppen K, et al. Int J Med Microbiol 2019. PMID 31451389
Other Francisella species are known but less is understood about their virulence factors. The role of environmental amoebae in the life-cycle of Francisella is still under discussion. ...In these experiments, we identified 79 scatter clones (amoeba sensitive), which were further analyzed by an infection assay identifying 9 known virulence factors, but also candidate fitness factors of F-W12 not yet described as fitness factors in Francisella. ...
Other Francisella species are known but less is understood about their virulence factors. The role of environmental amoebae in the li …
Extracellular Vesicle-Mediated Communication Within Host-Parasite Interactions
Wu Z, et al. Front Immunol 2019 - Review. PMID 30697211 Free PMC article.
EVs can enable multiple modes to transfer virulence factors and effector molecules from parasites to hosts, thereby regulating host gene expression, and immune responses and, consequently, mediating the pathogenic process, which has made us rethink our understanding of the host-parasite interface. ...
EVs can enable multiple modes to transfer virulence factors and effector molecules from parasites to hosts, thereby regulating host g …
Cystic Fibrosis and Pseudomonas aeruginosa: the Host-Microbe Interface
Malhotra S, et al. Clin Microbiol Rev 2019 - Review. PMID 31142499 Free PMC article.
Importantly, P. aeruginosa exhibits significant resistance to innate immune effectors and to antibiotics, in part, by expressing specific virulence factors (e.g., antioxidants and exopolysaccharides) and by acquiring adaptive mutations during chronic infection. In an effort to review our current understanding of the host-pathogen interface driving CF pulmonary disease, we discuss (i) the progression of disease within the primitive CF lung, specifically focusing on the role of host versus bacterial factors; (ii) critical, neutrophil-derived innate immune effectors that are implicated in CF pulmonary disease, including reactive oxygen species (ROS) and antimicrobial peptides (e.g., LL-37); (iii) P. aeruginosa virulence factors and adaptive mutations that enable evasion of the host response; and (iv) ongoing work examining the distribution and colocalization of host and bacterial factors within distinct anatomical niches of the CF lung....
Importantly, P. aeruginosa exhibits significant resistance to innate immune effectors and to antibiotics, in part, by expressing specific …
Activity and Functional Importance of Helicobacter pylori Virulence Factors.
Sgouras D, et al. Adv Exp Med Biol 2019 - Review. PMID 31016624
The best characterized H. pylori virulence factors that cause direct cell damage include an effector protein encoded by the cytotoxin-associated gene A (CagA), a type IV secretion system (T4SS) encoded in the cag-pathogenicity island (cag PAI), vacuolating cytotoxin A (VacA), γ-glutamyl transpeptidase (GGT), high temperature requirement A (HtrA, a serine protease) and cholesterol glycosyl-transferase (CGT). ...
The best characterized H. pylori virulence factors that cause direct cell damage include an effector protein encoded by the cytotoxin …
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