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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1944 1
1945 22
1946 63
1947 78
1948 91
1949 71
1950 133
1951 149
1952 104
1953 106
1954 91
1955 108
1956 80
1957 92
1958 102
1959 66
1960 44
1961 60
1962 70
1963 130
1964 205
1965 120
1966 159
1967 205
1968 217
1969 258
1970 247
1971 236
1972 267
1973 264
1974 278
1975 238
1976 214
1977 224
1978 201
1979 231
1980 260
1981 233
1982 244
1983 201
1984 252
1985 252
1986 243
1987 187
1988 202
1989 163
1990 182
1991 162
1992 181
1993 176
1994 179
1995 226
1996 221
1997 283
1998 258
1999 352
2000 346
2001 347
2002 370
2003 471
2004 549
2005 735
2006 761
2007 897
2008 1010
2009 1195
2010 1552
2011 1833
2012 2101
2013 2312
2014 2353
2015 2480
2016 2476
2017 2495
2018 2303
2019 1098
2020 22
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33,854 results
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Page 1
Vitamin D Supplementation and Prevention of Type 2 Diabetes.
Pittas AG, et al. N Engl J Med 2019 - Clinical Trial. PMID 31173679 Free PMC article.
RESULTS: A total of 2423 participants underwent randomization (1211 to the vitamin D group and 1212 to the placebo group). By month 24, the mean serum 25-hydroxyvitamin D level in the vitamin D group was 54.3 ng per milliliter (from 27.7 ng per milliliter at baseline), as compared with 28.8 ng per milliliter in the placebo group (from 28.2 ng per milliliter at baseline). ...CONCLUSIONS: Among persons at high risk for type 2 diabetes not selected for vitamin D insufficiency, vitamin D(3) supplementation at a dose of 4000 IU per day did not result in a significantly lower risk of diabetes than placebo. ...
RESULTS: A total of 2423 participants underwent randomization (1211 to the vitamin D group and 1212 to the placebo group). By …
Vitamin D and health - The missing vitamin in humans.
Chang SW and Lee HC. Pediatr Neonatol 2019 - Review. PMID 31101452 Free article.
This paper discusses the researches regarding system-based vitamin D effects, the possible risk factors leading to vitamin D deficiency, and the recommendations of vitamin D requirements. ...Trials assessing the effects of vitamin D repletion and establishing its optimum serum level are ongoing. Medical advice for vitamin D supplementation should be individualized accordingly....
This paper discusses the researches regarding system-based vitamin D effects, the possible risk factors leading to vitamin
Nutrigenomics of Vitamin D.
Carlberg C. Nutrients 2019 - Review. PMID 30901909 Free PMC article.
This review will discuss different aspects of how vitamin D interacts with the human genome, focusing on nutritional epigenomics in context of immune responses. This should lead to a better understanding of the clinical benefits of vitamin D....
This review will discuss different aspects of how vitamin D interacts with the human genome, focusing on nutritional epigenomi …
Extra-Skeletal Effects of Vitamin D.
Marino R and Misra M. Nutrients 2019 - Review. PMID 31252594 Free PMC article.
Consequently, the extra-skeletal impact of vitamin D deficiency has been an active area of research. While epidemiological and case-control studies have often suggested a link between vitamin D deficiency and conditions such as type 1 and type 2 diabetes, connective tissue disorders, inflammatory bowel disorders, chronic hepatitis, food allergies, asthma and respiratory infections, and cancer, interventional studies for the most part have failed to confirm a causative link. This review examines available evidence to date for the extra-skeletal effects of vitamin D deficiency, with a focus on randomized controlled trials and meta-analyses....
Consequently, the extra-skeletal impact of vitamin D deficiency has been an active area of research. While epidemiological and …
Analysis of Association between Vitamin D Deficiency and Insulin Resistance.
Szymczak-Pajor I and Śliwińska A. Nutrients 2019 - Review. PMID 30959886 Free PMC article.
Both genomic and non-genomic action of vitamin D is directed towards insulin signaling. Thereby, vitamin D reduces the extent of pathologies associated with insulin resistance such as oxidative stress and inflammation. ...In conclusion, vitamin D deficiency is one of the factors accelerating insulin resistance formation. The results of basic and clinical research support beneficial action of vitamin D in the reduction of insulin resistance and related pathologies....
Both genomic and non-genomic action of vitamin D is directed towards insulin signaling. Thereby, vitamin D reduc …
The Role of Vitamin D in Inflammatory Bowel Disease: Mechanism to Management.
Fletcher J, et al. Nutrients 2019 - Review. PMID 31067701 Free PMC article.
Dietary malabsorption of vitamin D may also contribute to low serum 25(OH)D in IBD. The benefits of supplementation with vitamin D for IBD patients are still unclear, and improved vitamin D status may help to prevent the onset of IBD as well as ameliorating disease severity. ...The current narrative review aims to summarise the different strands of data linking vitamin D and IBD, whilst also outlining the possible beneficial effects of vitamin D supplementation in managing IBD in humans....
Dietary malabsorption of vitamin D may also contribute to low serum 25(OH)D in IBD. The benefits of supplementation with vi
Vitamin D and autoimmune diseases.
Illescas-Montes R, et al. Life Sci 2019 - Review. PMID 31401314
Vitamin D deficiency is a common factor in many of these diseases, whose etiology remains poorly understood. The objective of this study was to review published data on the role of vitamin D in ADs. ...We highlight the importance of measuring serum vitamin D levels of the population and developing strategies to improve and maintain levels with no health risks....
Vitamin D deficiency is a common factor in many of these diseases, whose etiology remains poorly understood. The objective of
Association between vitamin D supplementation and mortality: systematic review and meta-analysis.
Zhang Y, et al. BMJ 2019. PMID 31405892 Free PMC article.
Vitamin D supplementation statistically significantly reduced the risk of cancer death (0.84, 0.74 to 0.95, 0%). In subgroup analyses, all cause mortality was significantly lower in trials with vitamin D(3) supplementation than in trials with vitamin D(2) supplementation (P for interaction=0.04); neither vitamin D(3) nor vitamin D(2) was associated with a statistically significant reduction in all cause mortality. ...Vitamin D supplementation reduced the risk of cancer death by 16%. Additional large clinical studies are needed to determine whether vitamin D(3) supplementation is associated with lower all cause mortality. ...
Vitamin D supplementation statistically significantly reduced the risk of cancer death (0.84, 0.74 to 0.95, 0%). In subgroup a
Vitamin D and Cardiovascular Disease: An Update.
Zittermann A and Pilz S. Anticancer Res 2019 - Review. PMID 31519560
In the clinical setting, administration of high daily or bolus doses of vitamin D is often solely based on 25-hydroxyvitamin D [25(OH)D] testing. This review summarizes the evidence of the effect of vitamin D on cardiovascular disease (CVD). Meta-analyses of randomized controlled trials (RCTs) have demonstrated that CVD risk markers, such as lipid parameters, inflammation markers, blood pressure, and arterial stiffness, are largely unaffected by vitamin D supplementation. ...
In the clinical setting, administration of high daily or bolus doses of vitamin D is often solely based on 25-hydroxyvitamin D …
Early High-Dose Vitamin D(3) for Critically Ill, Vitamin D-Deficient Patients.
National Heart, Lung, and Blood Institute PETAL Clinical Trials Network , et al. N Engl J Med 2019 - Clinical Trial. PMID 31826336
The potential benefits of vitamin D supplementation in acute critical illness require further study. METHODS: We conducted a randomized, double-blind, placebo-controlled, phase 3 trial of early vitamin D(3) supplementation in critically ill, vitamin D-deficient patients who were at high risk for death. ...CONCLUSIONS: Early administration of high-dose enteral vitamin D(3) did not provide an advantage over placebo with respect to 90-day mortality or other, nonfatal outcomes among critically ill, vitamin D-deficient patients. ...
The potential benefits of vitamin D supplementation in acute critical illness require further study. METHODS: We conducted a r …
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