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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1989 1
2003 2
2004 1
2005 69
2006 233
2007 289
2008 387
2009 402
2010 387
2011 508
2012 389
2013 426
2014 395
2015 297
2016 328
2017 344
2018 339
2019 142
2020 3
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4,367 results
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Page 1
Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities.
Nusse R and Clevers H. Cell 2017 - Review. PMID 28575679 Free article.
Unsurprisingly, mutated Wnt pathway components are causative to multiple growth-related pathologies and to cancer. Here, we describe the core Wnt/β-catenin signaling pathway, how it controls stem cells, and contributes to disease. Finally, we discuss strategies for Wnt-based therapies....
Unsurprisingly, mutated Wnt pathway components are causative to multiple growth-related pathologies and to cancer. Here, we describe …
Canonical and non-canonical WNT signaling in cancer stem cells and their niches: Cellular heterogeneity, omics reprogramming, targeted therapy and tumor plasticity (Review).
Katoh M. Int J Oncol 2017 - Review. PMID 29048660 Free PMC article.
WNT signaling-targeted therapeutics are applicable for combination therapy with BCR-ABL, EGFR, FLT3, KIT or RET inhibitors to treat a subset of tyrosine kinase-driven cancers because WNT and tyrosine kinase signaling cascades converge to β-catenin for the maintenance and expansion of CSCs. WNT signaling-targeted therapeutics might also be applicable for combination therapy with immune checkpoint blockers, such as atezolizumab, avelumab, durvalumab, ipilimumab, nivolumab and pembrolizumab, to treat cancers with immune evasion, although the context-dependent effects of WNT signaling on immunity should be carefully assessed. ...
WNT signaling-targeted therapeutics are applicable for combination therapy with BCR-ABL, EGFR, FLT3, KIT or RET inhibitors to treat a
Fatty acylation of Wnt proteins.
Nile AH and Hannoush RN. Nat Chem Biol 2016. PMID 26784846
Wnt proteins are critical regulators of signaling networks during embryonic development and in adult tissue homeostasis. The generation of active Wnt proteins requires their regulated secretion into the extracellular space. ...Finally, we discuss models for the functional role of the unsaturated fatty acyl chain in mediating lipid-protein interactions and in Wnt trafficking....
Wnt proteins are critical regulators of signaling networks during embryonic development and in adult tissue homeostasis. The g
Adipocyte and adipogenesis
Ali AT, et al. Eur J Cell Biol 2013 - Review. PMID 23876739
Besides the classical function of storing fat, adipocytes secrete numerous lipid and protein factors. Collectively they are considered to constitute a major endocrine organ which has a profound impact on the metabolism of other tissues, the regulation of appetite, insulin sensitivity, immunological responses and vascular disease. ...Adipogenesis is a well-orchestrated multistep process that requires the sequential activation of numerous transcription factors, including the CCAAT/enhancer-binding protein (C/EBP) gene family and peroxisome proliferator activated receptor-γ (PPAR-γ). ...
Besides the classical function of storing fat, adipocytes secrete numerous lipid and protein factors. Collectively they are considere …
Canonical and noncanonical Wnt signaling in neural stem/progenitor cells.
Bengoa-Vergniory N and Kypta RM. Cell Mol Life Sci 2015 - Review. PMID 26306936 Free article.
The first mammalian Wnt to be discovered, Wnt-1, was found to be essential for the development of a large part of the mouse brain over 25 years ago. ...Wnt signals in the developing and adult brain can drive neural stem cell self-renewal, expansion, asymmetric cell division, maturation and differentiation. ...
The first mammalian Wnt to be discovered, Wnt-1, was found to be essential for the development of a large part of the mouse br …
Immobilized WNT Proteins Act as a Stem Cell Niche for Tissue Engineering.
Lowndes M, et al. Stem Cell Reports 2016. PMID 27411105 Free PMC article.
The timing, location, and level of WNT signaling are highly regulated during embryonic development and for the maintenance of adult tissues. Consequently the ability to provide a defined and directed source of WNT proteins is crucial to fully understand its role in tissue development and to mimic its activity in vitro. ...
The timing, location, and level of WNT signaling are highly regulated during embryonic development and for the maintenance of adult t …
A RECK-WNT7 Receptor-Ligand Interaction Enables Isoform-Specific Regulation of Wnt Bioavailability.
Vallon M, et al. Cell Rep 2018. PMID 30304675 Free PMC article.
The GPI-anchored protein RECK and adhesion G protein-coupled receptor GPR124 critically regulate WNT7-specific signaling in concert with FZD and LRP co-receptors. ...Overall, RECK is a selective WNT7 receptor that mediates GPR124/FZD/LRP-dependent canonical Wnt/β-catenin signaling by stabilizing active cell surface WNT7, suggesting isoform-specific regulation of Wnt bioavailability....
The GPI-anchored protein RECK and adhesion G protein-coupled receptor GPR124 critically regulate WNT7-specific signaling in co …
'WNT-er is coming': WNT signalling in chronic lung diseases.
Baarsma HA and Königshoff M. Thorax 2017 - Review. PMID 28416592 Free PMC article.
Over the last decade, there has been extensive interest in investigating Wingless/integrase-1 (WNT) signalling pathways; and WNT signal alterations have been linked to pulmonary disease pathogenesis and progression. ...We further discuss recent advances uncovering the role of WNT signalling early in life, the potential of pharmaceutically modulating WNT signalling pathways and highlight (pre)clinical studies describing promising new therapies for chronic lung diseases....
Over the last decade, there has been extensive interest in investigating Wingless/integrase-1 (WNT) signalling pathways; and WNT
WNT-5A: signaling and functions in health and disease.
Kumawat K and Gosens R. Cell Mol Life Sci 2016 - Review. PMID 26514730 Free PMC article.
WNT-5A plays critical roles in a myriad of processes from embryonic morphogenesis to the maintenance of post-natal homeostasis. WNT-5A knock-out mice fail to survive and present extensive structural malformations. WNT-5A predominantly activates β-catenin-independent WNT signaling cascade but can also activate β-catenin signaling to relay its diverse cellular effects such as cell polarity, migration, proliferation, cell survival, and immunomodulation. ...
WNT-5A plays critical roles in a myriad of processes from embryonic morphogenesis to the maintenance of post-natal homeostasis. WN
SIRT6 Controls Hematopoietic Stem Cell Homeostasis through Epigenetic Regulation of Wnt Signaling.
Wang H, et al. Cell Stem Cell 2016. PMID 27058938 Free article.
Proper regulation of Wnt signaling is critical for the maintenance of hematopoietic stem cell (HSC) homeostasis. The epigenetic regulation of Wnt signaling in HSCs remains largely unknown. ...Pharmacological inhibition of the Wnt pathway rescued the aberrant proliferation and functional defect in SIRT6-deficient HSCs. ...
Proper regulation of Wnt signaling is critical for the maintenance of hematopoietic stem cell (HSC) homeostasis. The epigenetic regul …
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