Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

MyNCBI Filters
Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2003 2
2004 1
2005 72
2006 260
2007 324
2008 434
2009 459
2010 483
2011 515
2012 387
2013 392
2014 384
2015 324
2016 313
2017 270
2018 251
2019 110
2020 1
Text availability
Article attribute
Article type
Publication date

Search Results

4,396 results
Results by year
Filters applied: . Clear all
Page 1
Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities.
Nusse R and Clevers H. Cell 2017 - Review. PMID 28575679 Free article.
Unsurprisingly, mutated Wnt pathway components are causative to multiple growth-related pathologies and to cancer. Here, we describe the core Wnt/β-catenin signaling pathway, how it controls stem cells, and contributes to disease. Finally, we discuss strategies for Wnt-based therapies....
Unsurprisingly, mutated Wnt pathway components are causative to multiple growth-related pathologies and to cancer. Here, we describe …
Wnt/β-catenin signaling and disease.
Clevers H and Nusse R. Cell 2012 - Review. PMID 22682243 Free article.
The WNT signal transduction cascade controls myriad biological phenomena throughout development and adult life of all animals. In parallel, aberrant Wnt signaling underlies a wide range of pathologies in humans. In this Review, we provide an update of the core Wnt/β-catenin signaling pathway, discuss how its various components contribute to disease, and pose outstanding questions to be addressed in the future....
The WNT signal transduction cascade controls myriad biological phenomena throughout development and adult life of all animals. In par …
Wnt signaling and cellular metabolism in osteoblasts.
Karner CM and Long F. Cell Mol Life Sci 2017 - Review. PMID 27888287 Free PMC article.
Importantly, recent studies have uncovered that Wnt signaling directly reprograms cellular metabolism by stimulating aerobic glycolysis, glutamine catabolism as well as fatty acid oxidation in osteoblast-lineage cells. ...A comprehensive understanding of osteoblast metabolism and its regulation is likely to reveal molecular targets for novel bone therapies....
Importantly, recent studies have uncovered that Wnt signaling directly reprograms cellular metabolism by stimulating aerobic g …
Wnt/beta-catenin signaling: components, mechanisms, and diseases.
MacDonald BT, et al. Dev Cell 2009 - Review. PMID 19619488 Free PMC article.
Signaling by the Wnt family of secreted glycolipoproteins via the transcriptional coactivator beta-catenin controls embryonic development and adult homeostasis. Here we review recent progress in this so-called canonical Wnt signaling pathway. We discuss Wnt ligands, agonists, and antagonists, and their interactions with Wnt receptors. ...
Signaling by the Wnt family of secreted glycolipoproteins via the transcriptional coactivator beta-catenin controls embryonic develop …
Active Wnt proteins are secreted on exosomes.
Gross JC, et al. Nat Cell Biol 2012. PMID 22983114
Wnt signalling has important roles during development and in many diseases. As morphogens, hydrophobic Wnt proteins exert their function over a distance to induce patterning and cell differentiation decisions. ...Our study demonstrates an evolutionarily conserved functional role of extracellular vesicular transport of Wnt proteins....
Wnt signalling has important roles during development and in many diseases. As morphogens, hydrophobic Wnt proteins exe
Stem cell signaling. An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control.
Clevers H, et al. Science 2014 - Review. PMID 25278615
Wnt signals emanating from the niche can act as self-renewal factors for stem cells in multiple mammalian tissues. Wnt proteins are lipid-modified, which constrains them to act as short-range cellular signals. The locality of Wnt signaling dictates that stem cells exiting the Wnt signaling domain differentiate, spatially delimiting the niche in certain tissues. ...
Wnt signals emanating from the niche can act as self-renewal factors for stem cells in multiple mammalian tissues. Wnt prot
Differences in the secretion and transport of Wnt proteins.
Takada S, et al. J Biochem 2017 - Review. PMID 28053142
In parallel, the molecular nature of Wnt proteins has gradually but surely been clarified. Wnt proteins are post-translationaly modified with fatty acid and glycosaminoglycans, resulting in constraint of the 3D structure and behavior of the proteins. Specific binding proteins or extracellular vesicles, which appear to shield the lipid moiety from the aquatic environment, enable Wnt proteins to be transported in the extracellular space. ...
In parallel, the molecular nature of Wnt proteins has gradually but surely been clarified. Wnt proteins are post …
Canonical and Non-Canonical Wnt Signaling in Immune Cells.
Chae WJ and Bothwell ALM. Trends Immunol 2018 - Review. PMID 30213499
Wnt signaling plays essential roles in processes across species. The roles of Wnt signaling proteins and Wnt ligands have been studied in the past, but the context-dependent mechanisms and functions of these pathways in immune responses remain unclear. Recent findings regarding the role of Wnt ligands and Wnt signaling in immune cells and their immunomodulatory mechanisms suggest that Wnt ligands and signaling are significant in regulating immune responses. ...
Wnt signaling plays essential roles in processes across species. The roles of Wnt signaling proteins and Wnt lig
WNT signaling: an emerging mediator of cancer cell metabolism?
Sherwood V. Mol Cell Biol 2015 - Review. PMID 25348713 Free PMC article.
While the majority of WNT metabolism research has focused on nontransformed tissues, the role of WNT in cancer metabolism remains underinvestigated. ...This review highlights the emerging evidence for WNT signaling in the reprogramming of cancer cell metabolism and examines the role of these signaling pathways as mediators of tumor bioenergetics....
While the majority of WNT metabolism research has focused on nontransformed tissues, the role of WNT in cancer metab
Wnt proteins contribute to neuromuscular junction formation through distinct signaling pathways.
Messéant J, et al. Development 2017. PMID 28348167 Free article.
Wnt morphogens are key players in the formation of this specialized peripheral synapse, but their individual and collaborative functions and downstream pathways remain poorly understood at the NMJ. ...By contrast, loss of Wnt11 or Wnt-dependent signaling in vivo decreases AChR clustering and motor nerve terminal branching. Both Wnt4 and Wnt11 stimulate AChR mRNA levels and AChR clustering downstream of activation of the β-catenin pathway. ...
Wnt morphogens are key players in the formation of this specialized peripheral synapse, but their individual and collaborative functi
4,396 results
Jump to page
Feedback