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1994 1
1995 2
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1997 4
1999 3
2001 2
2002 1
2004 1
2005 1
2006 4
2007 2
2008 7
2009 6
2010 13
2011 17
2012 18
2013 41
2014 47
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2017 95
2018 122
2019 42
2020 1
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Page 1
Role of YAP/TAZ in mechanotransduction.
Dupont S, et al. Nature 2011. PMID 21654799
Here we report the identification of the Yorkie-homologues YAP (Yes-associated protein) and TAZ (transcriptional coactivator with PDZ-binding motif, also known as WWTR1) as nuclear relays of mechanical signals exerted by ECM rigidity and cell shape. ...These findings identify YAP/TAZ as sensors and mediators of mechanical cues instructed by the cellular microenvironment....
Here we report the identification of the Yorkie-homologues YAP (Yes-associated protein) and TAZ (transcriptional coactivator w …
Yes-associated protein (YAP) mediates adaptive cardiac hypertrophy in response to pressure overload.
Byun J, et al. J Biol Chem 2019. PMID 30635403 Free PMC article.
Yes-associated protein (YAP), the central downstream effector of the Hippo signaling pathway, regulates proliferation and survival in mammalian cells. Our previous work demonstrated that cardiac-specific loss of YAP leads to increased cardiomyocyte (CM) apoptosis and impaired CM hypertrophy during chronic myocardial infarction (MI) in the mouse heart. ...
Yes-associated protein (YAP), the central downstream effector of the Hippo signaling pathway, regulates proliferation and surv …
Alternative Wnt Signaling Activates YAP/TAZ.
Park HW, et al. Cell 2015. PMID 26276632 Free PMC article.
Here, we discover YAP/TAZ as bona fide downstream effectors of the alternative Wnt signaling pathway. Wnt5a/b and Wnt3a induce YAP/TAZ activation independent of canonical Wnt/β-catenin signaling. Mechanistically, we delineate the "alternative Wnt-YAP/TAZ signaling axis" that consists of Wnt-FZD/ROR-Gα12/13-Rho GTPases-Lats1/2 to promote YAP/TAZ activation and TEAD-mediated transcription. ...
Here, we discover YAP/TAZ as bona fide downstream effectors of the alternative Wnt signaling pathway. Wnt5a/b and Wnt3a induce YAP
Force Triggers YAP Nuclear Entry by Regulating Transport across Nuclear Pores.
Elosegui-Artola A, et al. Cell 2017. PMID 29107331 Free article.
YAP is a mechanosensitive transcriptional activator with a critical role in cancer, regeneration, and organ size control. Here, we show that force applied to the nucleus directly drives YAP nuclear translocation by decreasing the mechanical restriction of nuclear pores to molecular transport. ...The restriction to transport is further regulated by the mechanical stability of the transported protein, which determines both active nuclear transport of YAP and passive transport of small proteins. ...
YAP is a mechanosensitive transcriptional activator with a critical role in cancer, regeneration, and organ size control. Here, we sh
The Hippo pathway effector YAP controls mouse hepatic stellate cell activation.
Mannaerts I, et al. J Hepatol 2015. PMID 25908270
YAP was also activated in stellate cells of human fibrotic livers as evidenced by its nuclear localization. Importantly, knockdown of YAP expression or pharmacological inhibition of YAP prevented hepatic stellate cell activation in vitro and pharmacological inhibition of YAP impeded fibrogenesis in mice. CONCLUSIONS: YAP activation is a critical driver of hepatic stellate cell activation and inhibition of YAP presents a novel approach for the treatment of liver fibrosis....
YAP was also activated in stellate cells of human fibrotic livers as evidenced by its nuclear localization. Importantly, knockdown of
NUAK2 is a critical YAP target in liver cancer.
Yuan WC, et al. Nat Commun 2018. PMID 30446657 Free PMC article.
The Hippo-YAP signaling pathway is a critical regulator of proliferation, apoptosis, and cell fate. The main downstream effector of this pathway, YAP, has been shown to be misregulated in human cancer and has emerged as an attractive target for therapeutics. ...Importantly, our work here identifies a specific, potent, and actionable target for YAP-driven malignancies....
The Hippo-YAP signaling pathway is a critical regulator of proliferation, apoptosis, and cell fate. The main downstream effector of t …
SET1A-Mediated Mono-Methylation at K342 Regulates YAP Activation by Blocking Its Nuclear Export and Promotes Tumorigenesis.
Fang L, et al. Cancer Cell 2018. PMID 30008322 Free article.
Although the mechanism by which YAP is suppressed in cytoplasm has been well-studied, how the activated YAP is sequestered in the nucleus remains unknown. Here, we demonstrate that YAP is a nucleocytoplasmic shuttling protein and its nuclear export is controlled by SET1A-mediated mono-methylation of YAP at K342, which disrupts the binding of YAP to CRM1. ...
Although the mechanism by which YAP is suppressed in cytoplasm has been well-studied, how the activated YAP is sequestered in …
Tumor metastasis to lymph nodes requires YAP-dependent metabolic adaptation.
Lee CK, et al. Science 2019. PMID 30733421
Transcriptional coactivator yes-associated protein (YAP) is selectively activated in LN-metastatic tumors, leading to the up-regulation of genes in the FAO signaling pathway. Pharmacological inhibition of FAO or genetic ablation of YAP suppressed LN metastasis in mice. Several bioactive bile acids accumulated to high levels in the metastatic LNs, and these bile acids activated YAP in tumor cells, likely through the nuclear vitamin D receptor. ...
Transcriptional coactivator yes-associated protein (YAP) is selectively activated in LN-metastatic tumors, leading to the up-r …
YAP/TAZ Orchestrate VEGF Signaling during Developmental Angiogenesis.
Wang X, et al. Dev Cell 2017. PMID 28867486 Free article.
We demonstrate that YAP/TAZ are essential for vascular development as endothelium-specific deletion of YAP/TAZ leads to impaired vascularization and embryonic lethality. Mechanistically, we show that VEGF activates YAP/TAZ via its effects on actin cytoskeleton and that activated YAP/TAZ induce a transcriptional program to further control cytoskeleton dynamics and thus establish a feedforward loop that ensures a proper angiogenic response. ...
We demonstrate that YAP/TAZ are essential for vascular development as endothelium-specific deletion of YAP/TAZ leads to impair …
YAP determines the cell fate of injured mouse hepatocytes in vivo.
Miyamura N, et al. Nat Commun 2017. PMID 28681838 Free PMC article.
Here, we show that YAP activation induced by inactivation of the Hippo pathway specifically in damaged hepatocytes promotes their selective elimination by using in vivo mosaic analysis in mouse liver. ...In contrast, YAP activation in undamaged hepatocytes leads to proliferation. Cellular stresses such as ethanol that damage both liver sinusoidal endothelial cells and hepatocytes switch cell fate from proliferation to migration/apoptosis in the presence of activated YAP. ...
Here, we show that YAP activation induced by inactivation of the Hippo pathway specifically in damaged hepatocytes promotes their sel …
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