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Page 1
Clinical, Immunological, and Genetic Features in 49 Patients With ZAP-70 Deficiency: A Systematic Review.
Sharifinejad N, Jamee M, Zaki-Dizaji M, Lo B, Shaghaghi M, Mohammadi H, Jadidi-Niaragh F, Shaghaghi S, Yazdani R, Abolhassani H, Aghamohammadi A, Azizi G. Sharifinejad N, et al. Front Immunol. 2020 May 5;11:831. doi: 10.3389/fimmu.2020.00831. eCollection 2020. Front Immunol. 2020. PMID: 32431715 Free PMC article.
Background: Zeta-Chain Associated Protein Kinase 70 kDa (ZAP-70) deficiency is a rare combined immunodeficiency (CID) caused by recessive homozygous/compound heterozygous loss-of-function mutations in the ZAP70 gene. Patients with ZAP-70 defi …
Background: Zeta-Chain Associated Protein Kinase 70 kDa (ZAP-70) deficiency is a rare combined immunodeficiency (CID) c …
SCID due to ZAP-70 deficiency.
Elder ME. Elder ME. J Pediatr Hematol Oncol. 1997 Nov-Dec;19(6):546-50. doi: 10.1097/00043426-199711000-00014. J Pediatr Hematol Oncol. 1997. PMID: 9407944 Review. No abstract available.
ZAP-70 mutation: a case with familial autoimmune haemolytic anaemia and immune deficiency.
Abd Elhamed MM, Wali Y, Youssry I. Abd Elhamed MM, et al. BMJ Case Rep. 2024 Mar 18;17(3):e258835. doi: 10.1136/bcr-2023-258835. BMJ Case Rep. 2024. PMID: 38499350 Free PMC article.
Zeta-chain associated protein kinase 70 kDa (ZAP-70) deficiency is one of the rare immunodeficiency disorders due to autosomal recessive homozygous or compound heterozygous loss-of-function mutations in the ZAP-70 GENE In the literature, patients with ZAP …
Zeta-chain associated protein kinase 70 kDa (ZAP-70) deficiency is one of the rare immunodeficiency disorders due to au …
Two patients with ZAP-70 deficiency in China present with a different genetic, immunological, and clinical phenotype.
Luo X, Liu Q, Zhou L, Tang X, Zhao X, Zhang Z. Luo X, et al. BMC Pediatr. 2023 Apr 26;23(1):195. doi: 10.1186/s12887-023-03975-6. BMC Pediatr. 2023. PMID: 37101133 Free PMC article.
Zeta(zeta)-Chain Associated Protein Kinase 70 kDa (ZAP-70) deficiency is a rare autosomal recessive primary immunodeficiency disease. Little is known about this disease. ...Selective CD8 + T cell loss is an essential feature of the immunophenotype of ZAP …
Zeta(zeta)-Chain Associated Protein Kinase 70 kDa (ZAP-70) deficiency is a rare autosomal recessive primary immunodefic …
ZAP-70 constitutively regulates gene expression and protein synthesis in chronic lymphocytic leukemia.
Chen J, Sathiaseelan V, Moore A, Tan S, Chilamakuri CSR, Roamio Franklin VN, Shahsavari A, Jakwerth CA, Hake SB, Warren AJ, Mohorianu I, D'Santos C, Ringshausen I. Chen J, et al. Blood. 2021 Jul 1;137(26):3629-3640. doi: 10.1182/blood.2020009960. Blood. 2021. PMID: 33619528 Free article.
We identified that ZAP-70 is directly required for cell survival in the absence of an overt BCR signal, which can compensate for ZAP-70 deficiency as an antiapoptotic signal. In addition, the expression of ZAP-70 regulates the transcription of factors regulat …
We identified that ZAP-70 is directly required for cell survival in the absence of an overt BCR signal, which can compensate for ZAP- …
ZAP-70 Regulates Autoimmune Arthritis via Alterations in T Cell Activation and Apoptosis.
Kugyelka R, Prenek L, Olasz K, Kohl Z, Botz B, Glant TT, Berki T, Boldizsár F. Kugyelka R, et al. Cells. 2019 May 24;8(5):504. doi: 10.3390/cells8050504. Cells. 2019. PMID: 31137740 Free PMC article.
A key molecule in T cell activation is ZAP-70, therefore we aimed to investigate the effects of partial ZAP-70 deficiency on the pathogenesis of recombinant human G1(rhG1)-induced arthritis (GIA), a well-established mouse model of RA. ...
A key molecule in T cell activation is ZAP-70, therefore we aimed to investigate the effects of partial ZAP-70 deficiency …
[Primary immunodeficiency secondary to ZAP-70 deficiency].
Barata LT, Henriques R, Hivroz C, Jouanguy E, Paiva A, Freitas AM, Coimbra HB, Fischer A, da Mota HC. Barata LT, et al. Acta Med Port. 2001 Jul-Aug;14(4):413-7. Acta Med Port. 2001. PMID: 11762183 Free article. Portuguese.
ZAP-70 cDNA sequencing showed a mutation, and no ZAP-70 protein was detected in T cells. ZAP-70 deficiency is associated with a rare immune deficiency with absence of CD8+ T cells as well as a functional deficiency in T cells. ...
ZAP-70 cDNA sequencing showed a mutation, and no ZAP-70 protein was detected in T cells. ZAP-70 deficiency is associate …
30 results