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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 1
1995 1
1997 4
1998 10
1999 9
2000 12
2001 12
2002 5
2003 13
2004 17
2005 14
2006 32
2007 21
2008 29
2009 45
2010 36
2011 51
2012 53
2013 48
2014 48
2015 62
2016 49
2017 46
2018 34
2019 18
2020 0
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587 results
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Page 1
Regulation of Gli2 stability by deubiquitinase OTUB2.
Li XY, et al. Biochem Biophys Res Commun 2018. PMID 30241937
Here we have identified the eubiquitinating enzyme otubain2 (OTUB2) as a regulator of Gli2 protein degradation. We found that OTUB2 was coimmunoprecipitated with Gli2. Knockdown of OTUB2 decreased Gli2 protein level while the proteasome inhibitor MG-132 treatment restored Gli2 expression. Additionally, OTUB2 overexpression stabilized Gli2 protein in U2OS cells and extended the half-life of Gli2. ...
Here we have identified the eubiquitinating enzyme otubain2 (OTUB2) as a regulator of Gli2 protein degradation. We found that …
GLI2 promotes cell proliferation and migration through transcriptional activation of ARHGEF16 in human glioma cells.
Huang D, et al. J Exp Clin Cancer Res 2018. PMID 30305138 Free PMC article.
In contrast to the promoting effect of GLI2A overexpression on glioma xenograft growth, both GLI2 inhibition and ARHGEF16 knockdown retarded tumor growth. Cytoskeleton-associated protein 5 (CKAP5) was identified as an interaction protein of ARHGEF16, which is important for the stimulatory effects of ARHGEF16 on glioma cell migration and proliferation. ...
In contrast to the promoting effect of GLI2A overexpression on glioma xenograft growth, both GLI2 inhibition and ARHGEF16 knockdown r …
The zinc-finger transcription factor GLI2 antagonizes contact inhibition and differentiation of human epidermal cells.
Regl G, et al. Oncogene 2004. PMID 14691458
The zinc-finger transcription factor Gli2 has been identified as critical mediator of the Hh signal at the distal end of the pathway, but the molecular mechanisms by which Gli2 regulates cell proliferation or induces epidermal malignancies such as basal cell carcinoma are still unclear. ...Analysis of the proliferative effect of GLI2 revealed that GLI2 is able to induce G1-S phase progression in contact-inhibited keratinocytes. ...
The zinc-finger transcription factor Gli2 has been identified as critical mediator of the Hh signal at the distal end o …
Gli2 modulates cell cycle re-entry through autophagy-mediated regulation of the length of primary cilia.
Hsiao CJ, et al. J Cell Sci 2018. PMID 30463852 Free article.
To understand the significance of the Gli2 transcription factor in fibroblasts, we establish a Gli2-knockout NIH3T3 cell line by CRISPR/Cas9 technology. ...Meanwhile, flow cytometry reveals that Gli2(-/-) NIH3T3 fibroblasts exhibit a delay in cell cycle re-entry after serum re-stimulation. ...
To understand the significance of the Gli2 transcription factor in fibroblasts, we establish a Gli2-knockout NIH3T3 cell line …
The zinc finger transcription factor Gli2 mediates bone morphogenetic protein 2 expression in osteoblasts in response to hedgehog signaling.
Zhao M, et al. Mol Cell Biol 2006. PMID 16880529 Free PMC article.
Bone morphogenetic protein 2 (BMP-2) plays a critical role in osteoblast function. In Drosophila, Cubitus interruptus (Ci), which mediates hedgehog signaling, regulates gene expression of dpp, the ortholog of mammalian BMP-2. ...In contrast, knocking down Gli2 expression by Gli2 small interfering RNA or genetic ablation of the Gli2 gene results in significant inhibition of BMP-2 gene expression in osteoblasts. ...
Bone morphogenetic protein 2 (BMP-2) plays a critical role in osteoblast function. In Drosophila, Cubitus interruptus (Ci), which med …
Genomic analysis of smoothened inhibitor resistance in basal cell carcinoma
Sharpe HJ, et al. Cancer Cell 2015. PMID 25759019 Free PMC article.
Genomic analysis of tumor biopsies revealed that vismodegib resistance is associated with Hedgehog (Hh) pathway reactivation, predominantly through mutation of the drug target SMO and to a lesser extent through concurrent copy number changes in SUFU and GLI2. ...
Genomic analysis of tumor biopsies revealed that vismodegib resistance is associated with Hedgehog (Hh) pathway reactivation, predominantly …
Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition
Kool M, et al. Cancer Cell 2014. PMID 24651015 Free PMC article.
Children >3 years old harbored an excess of downstream MYCN and GLI2 amplifications and frequent TP53 mutations, often in the germline, all of which were rare in infants and adults. ...
Children >3 years old harbored an excess of downstream MYCN and GLI2 amplifications and frequent TP53 mutations, often in the germ …
Pharmacological GLI2 inhibition prevents myofibroblast cell-cycle progression and reduces kidney fibrosis.
Kramann R, et al. J Clin Invest 2015. PMID 26193634 Free PMC article.
Pharmacologic targeting of this pathway with darinaparsin, an arsenical in clinical trials, reduced fibrosis through reduction of GLI2 protein levels and subsequent cell-cycle arrest in myofibroblasts. GLI2 overexpression rescued the cell-cycle effect of darinaparsin in vitro. While darinaparsin ameliorated fibrosis in WT and Gli1-KO mice, it was not effective in conditional Gli2-KO mice, supporting GLI2 as a direct darinaparsin target. ...
Pharmacologic targeting of this pathway with darinaparsin, an arsenical in clinical trials, reduced fibrosis through reduction of GLI2
Hypoxic tumor microenvironment activates GLI2 via HIF-1α and TGF-β2 to promote chemoresistance in colorectal cancer.
Tang YA, et al. Proc Natl Acad Sci U S A 2018. PMID 29891662 Free PMC article.
Genetic or small-molecule inhibitor-based ablation of HIF-1α/TGF-β2-mediated GLI2 signaling effectively reversed the chemoresistance caused by the tumor microenvironment. Importantly, high expression levels of HIF-1α/TGF-β2/GLI2 correlated robustly with the patient relapse following chemotherapy, highlighting a potential biomarker and therapeutic target for chemoresistance in colorectal cancer. ...
Genetic or small-molecule inhibitor-based ablation of HIF-1α/TGF-β2-mediated GLI2 signaling effectively reversed the chemoresistance …
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