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Automating Predictive Phage Therapy Pharmacology.
Abedon ST. Abedon ST. Antibiotics (Basel). 2023 Sep 8;12(9):1423. doi: 10.3390/antibiotics12091423. Antibiotics (Basel). 2023. PMID: 37760719 Free PMC article. Review.
Viruses that infect as well as often kill bacteria are called bacteriophages, or phages. Because of their ability to act bactericidally, phages increasingly are being employed clinically as antibacterial agents, an infection-fighting strategy that has been in …
Viruses that infect as well as often kill bacteria are called bacteriophages, or phages. Because of their ability to act bacte …
Determination of phage susceptibility as a clinical diagnostic tool: A routine perspective.
Daubie V, Chalhoub H, Blasdel B, Dahma H, Merabishvili M, Glonti T, De Vos N, Quintens J, Pirnay JP, Hallin M, Vandenberg O. Daubie V, et al. Front Cell Infect Microbiol. 2022 Sep 21;12:1000721. doi: 10.3389/fcimb.2022.1000721. eCollection 2022. Front Cell Infect Microbiol. 2022. PMID: 36211951 Free PMC article. Review.
As the global burden of disease caused by multidrug resistant bacteria is a major source of concern, credible clinical alternatives to antibiotic therapy, such as personalized phage therapy, are actively explored. Although phage therapy has been used for more than a …
As the global burden of disease caused by multidrug resistant bacteria is a major source of concern, credible clinical alternatives to antib …
Active bacteriophage biocontrol and therapy on sub-millimeter scales towards removal of unwanted bacteria from foods and microbiomes.
Abedon ST. Abedon ST. AIMS Microbiol. 2017 Aug 4;3(3):649-688. doi: 10.3934/microbiol.2017.3.649. eCollection 2017. AIMS Microbiol. 2017. PMID: 31294181 Free PMC article.
Bacteriophages can be used as antibacterial agents as a form of biological control, e.g., such as phage therapy. With active treatment, phages must "actively" produce new virions, in situ, to attain "inundative" densities, i.e., sufficient titer …
Bacteriophages can be used as antibacterial agents as a form of biological control, e.g., such as phage therapy. With activ …
The gut microbiota in multiple sclerosis varies with disease activity.
Thirion F, Sellebjerg F, Fan Y, Lyu L, Hansen TH, Pons N, Levenez F, Quinquis B, Stankevic E, Søndergaard HB, Dantoft TM, Poulsen CS, Forslund SK, Vestergaard H, Hansen T, Brix S, Oturai A, Sørensen PS, Ehrlich SD, Pedersen O. Thirion F, et al. Genome Med. 2023 Jan 5;15(1):1. doi: 10.1186/s13073-022-01148-1. Genome Med. 2023. PMID: 36604748 Free PMC article.
Bacterial species that were more abundant in cases with disease-active treatment-naive multiple sclerosis were positively linked to a group of plasma cytokines including IL-22, IL-17A, IFN-beta, IL-33, and TNF-alpha. ...In addition, cases with multiple sclerosis had …
Bacterial species that were more abundant in cases with disease-active treatment-naive multiple sclerosis were positively link …
How Simple Maths Can Inform Our Basic Understanding of Phage Therapy.
Abedon ST. Abedon ST. Clin Infect Dis. 2023 Nov 2;77(Suppl 5):S401-S406. doi: 10.1093/cid/ciad480. Clin Infect Dis. 2023. PMID: 37932116 Free PMC article.
Phage therapy is the application of bacterial viruses to control and, ideally, to eliminate problematic bacteria from patients. ...This killing occurs with single-hit kinetics, resulting in relatively simple ways to mathematically model organismal-level, phage-bacte …
Phage therapy is the application of bacterial viruses to control and, ideally, to eliminate problematic bacteria from patients. ...Th …
The role of regulated clinical trials in the development of bacteriophage therapeutics.
Parracho HM, Burrowes BH, Enright MC, McConville ML, Harper DR. Parracho HM, et al. J Mol Genet Med. 2012;6:279-86. doi: 10.4172/1747-0862.1000050. Epub 2012 Apr 23. J Mol Genet Med. 2012. PMID: 22872803 Free PMC article.
Antibiotic resistance is now recognized as a major, global threat to human health and the need for the development of novel antibacterial therapies has become urgent. Lytic bacteriophages (phages) targeting individual bacterial pathogens have therapeutic potential a …
Antibiotic resistance is now recognized as a major, global threat to human health and the need for the development of novel antibacterial th …