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2001 1
2003 2
2004 5
2005 3
2006 5
2007 3
2008 2
2009 6
2010 1
2011 4
2012 4
2013 1
2014 2
2016 1
2017 1
2019 1
2020 0
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Page 1
Adiponutrin: a multimeric plasma protein.
Winberg ME, et al. Biochem Biophys Res Commun 2014. PMID 24680680 Free article.
The interest in adiponutrin stems from adiponutrin variant I148M, which is strongly associated to non-alcoholic fatty liver disease. ...However, a physiologically relevant role for adiponutrin has not been found. The aim of this study was to investigate the presence of adiponutrin in human plasma, a new facet of adiponutrin research. ...
The interest in adiponutrin stems from adiponutrin variant I148M, which is strongly associated to non-alcoholic fatty liver di …
Expression, regulation, and triglyceride hydrolase activity of Adiponutrin family members.
Lake AC, et al. J Lipid Res 2005. PMID 16150821 Free article.
Using bioinformatics, we identified three additional Adiponutrin family members (GS2, GS2-Like, and PNPLA1). Here, we report on the expression, regulation, and activity of GS2 and GS2-Like compared with Adiponutrin and Desnutrin/ATGL. GS2-Like is expressed and regulated in a manner similar to Adiponutrin; however, the absolute levels of mRNA are significantly lower than those of Adiponutrin or Desnutrin/ATGL. ...
Using bioinformatics, we identified three additional Adiponutrin family members (GS2, GS2-Like, and PNPLA1). Here, we report on the e …
Adiponutrin gene is regulated by insulin and glucose in human adipose tissue.
Moldes M, et al. Eur J Endocrinol 2006. PMID 16914601
OBJECTIVE: Adiponutrin is a new transmembrane protein specifically expressed in adipose tissue. In obese subjects, short- or long-term calorie restriction diets were associated with a reduction in adiponutrin gene expression. ...Adiponutrin gene expression was also analyzed in patients with different levels of insulin resistance. RESULTS: During EGHI, insulin infusion induced adiponutrin gene expression 8.4-fold (P = 0.008). ...
OBJECTIVE: Adiponutrin is a new transmembrane protein specifically expressed in adipose tissue. In obese subjects, short- or long-ter …
Adipose triglyceride lipase: function, regulation by insulin, and comparison with adiponutrin.
Kershaw EE, et al. Diabetes 2006. PMID 16380488 Free PMC article.
In contrast, siRNA-mediated knockdown of adiponutrin in 3T3-L1 adipocytes had no effect on glycerol or NEFA release. In mice, both ATGL and adiponutrin are nutritionally regulated in adipose tissue, with ATGL being upregulated and adiponutrin being downregulated by fasting. ...These data suggest that murine ATGL but not adiponutrin contributes to net adipocyte lipolysis and that ATGL and adiponutrin are oppositely regulated by insulin both in vitro and in vivo....
In contrast, siRNA-mediated knockdown of adiponutrin in 3T3-L1 adipocytes had no effect on glycerol or NEFA release. In mice, both AT …
Regulation of adiponutrin expression by feeding conditions in rats is altered in the obese state.
Caimari A, et al. Obesity (Silver Spring) 2007. PMID 17372308 Free article.
The depot-specific adiponutrin expression is similar in lean and obese animals, except in the inguinal depot, where adiponutrin is overexpressed in obese Zucker. ...DISCUSSION: Adiponutrin expression is highly regulated by feeding conditions in the different adipose tissue depots, but this regulation is impaired in obese rats....
The depot-specific adiponutrin expression is similar in lean and obese animals, except in the inguinal depot, where adiponutrin
Cold exposure down-regulates adiponutrin/PNPLA3 mRNA expression and affects its nutritional regulation in adipose tissues of lean and obese Zucker rats.
Oliver P, et al. Br J Nutr 2012. PMID 21914237
Adiponutrin/PNPLA3 is a protein highly produced in adipose tissue whose expression is under tight nutritional regulation. It possesses lipogenic/lipolytic capacity and, although adiponutrin polymorphisms are related to obesity, its physiological role is not clear. ...Moreover, alterations in adiponutrin expression and regulation in adipose tissue are related to obesity....
Adiponutrin/PNPLA3 is a protein highly produced in adipose tissue whose expression is under tight nutritional regulation. It possesse
Diet-induced obesity affects expression of adiponutrin/PNPLA3 and adipose triglyceride lipase, two members of the same family.
Oliver P, et al. Int J Obes (Lond) 2012. PMID 21556044
In addition, basal adiponutrin and ATGL expression levels were compared between 6- and 3-month-old animals. RESULTS: Obesity decreased adiponutrin and ATGL expression in different adipose depots. ...Moreover, adiponutrin and ATGL nutritional regulation was affected by age, and we report a downregulation of adiponutrin mRNA basal levels with age in internal adipose depots. ...
In addition, basal adiponutrin and ATGL expression levels were compared between 6- and 3-month-old animals. RESULTS: Obesity decrease …
Adiponutrin, a transmembrane protein corresponding to a novel dietary- and obesity-linked mRNA specifically expressed in the adipose lineage.
Baulande S, et al. J Biol Chem 2001. PMID 11431482 Free article.
Based on its adipose specificity and dietary regulation, the novel gene product has been designated adiponutrin. The expression of adiponutrin mRNA is also 50-fold elevated in genetically obese fa/fa rats, indicating a link between adiponutrin and obesity. ...This leads us to suggest that adiponutrin could be involved in vesicular targeting and protein transport restricted to the adipocyte function....
Based on its adipose specificity and dietary regulation, the novel gene product has been designated adiponutrin. The expression of …
Adiponutrin: A new gene regulated by energy balance in human adipose tissue.
Liu YM, et al. J Clin Endocrinol Metab 2004. PMID 15181042
Adiponutrin is a newly identified nonsecreted adipocyte protein regulated by changes in energy balance in rodents. We documented the influence of energy balance modification on adiponutrin gene expression in humans. ...The adiponutrin mRNA levels of the nonobese and obese women were not different (P > 0.05). Two-day VLCD reduced the average level of adiponutrin mRNA expression by 36% (P = 0.0016), whereas refeeding elevated the mRNA level by 31% (P = 0.004). ...
Adiponutrin is a newly identified nonsecreted adipocyte protein regulated by changes in energy balance in rodents. We documented the
Insulin regulation of gene expression and concentrations of white adipose tissue-derived proteins in vivo in healthy men: relation to adiponutrin.
Faraj M, et al. J Endocrinol 2006 - Clinical Trial. PMID 17088412
To examine adiponutrin regulation by the insulin pathway in relation to other WAT-related proteins with well-known relation to insulin signaling and action, we examined in healthy young men (1) the association of adiponutrin with p85alpha PI3K and HKII, leptin, adiponectin, and acylation-stimulating protein (ASP) and (2) the regulation of adiponutrin and WAT-derived proteins by 3-h hyperinsulinemic euglycemic clamp (HIEG). ...We hypothesize that insulin-mediated regulation of adiponutrin expression is under the PI3K pathway. The relevance of the present findings to reduced adiponutrin expression in type 2 diabetes is discussed....
To examine adiponutrin regulation by the insulin pathway in relation to other WAT-related proteins with well-known relation to insuli …
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