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2025 34
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The mechanism of pathogenic α1-antitrypsin aggregation in the human liver.
Aldobiyan I, Elliston ELK, Heyer-Chauhan N, Arold ST, Zhao L, Huntington B, Lowen SM, Orlova EV, Irving JA, Lomas DA. Aldobiyan I, et al. Proc Natl Acad Sci U S A. 2025 Nov 18;122(46):e2507535122. doi: 10.1073/pnas.2507535122. Epub 2025 Nov 13. Proc Natl Acad Sci U S A. 2025. PMID: 41231946 Free PMC article.
Two randomised controlled phase 2 studies of the oral neutrophil elastase inhibitor alvelestat in alpha-1 antitrypsin deficiency.
Wells JM, Titlestad IL, Tanash H, Turner AM, Chapman KR, Hatipoğlu UŞ, Goldklang MP, D'Armiento JM, Pirozzi CS, Drummond MB, Barjaktarevic IZ, Chatila WM, Devine MS, Strange C, Sandhaus RA, Parkin JM, Westfall E, Lin VY, Parks R, Kuo HC, Ekue A, Moffitt KL, Inshaw J, Aban I, Dransfield MT, Stockley RA. Wells JM, et al. Eur Respir J. 2025 Dec 18;66(6):2501019. doi: 10.1183/13993003.01019-2025. Print 2025 Dec. Eur Respir J. 2025. PMID: 40967767 Free PMC article. Clinical Trial.
48 results