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Quoted phrase not found in phrase index: "angelo d'alessandro"
Page 1
Metabolic underpinnings of leukemia pathology and treatment.
Nemkov T, D'Alessandro A, Reisz JA. Nemkov T, et al. Among authors: d alessandro a. Cancer Rep (Hoboken). 2019 Apr;2(2):e1139. doi: 10.1002/cnr2.1139. Epub 2018 Oct 7. Cancer Rep (Hoboken). 2019. PMID: 32721091 Free PMC article. Review.
BACKGROUND: Carcinogenic transformation of white blood cells during hematopoiesis leads to the development of leukemia, a cancer characterized by incompetent immune cells and a disruption of normal bone marrow function. Leukemias are diverse in type, affected population, p …
BACKGROUND: Carcinogenic transformation of white blood cells during hematopoiesis leads to the development of leukemia, a cancer characteriz …
Macrophages recycle phagocytosed bacteria to fuel immunometabolic responses.
Lesbats J, Brillac A, Reisz JA, Mukherjee P, Lhuissier C, Fernández-Monreal M, Dupuy JW, Sequeira A, Tioli G, De La Calle Arregui C, Pinson B, Wendisch D, Rousseau B, Efeyan A, Sander LE, D'Alessandro A, Garaude J. Lesbats J, et al. Among authors: d alessandro a. Nature. 2025 Apr;640(8058):524-533. doi: 10.1038/s41586-025-08629-4. Epub 2025 Feb 26. Nature. 2025. PMID: 40011782
These results provide a new insight into the fate of engulfed microorganisms and highlight a microbial viability-associated metabolite that triggers host metabolic and immune responses. Our findings hold promise for shaping immunometabolic intervention for various immun …
These results provide a new insight into the fate of engulfed microorganisms and highlight a microbial viability-associated metabolite that …
In situ mapping identifies distinct vascular niches for myelopoiesis.
Zhang J, Wu Q, Johnson CB, Pham G, Kinder JM, Olsson A, Slaughter A, May M, Weinhaus B, D'Alessandro A, Engel JD, Jiang JX, Kofron JM, Huang LF, Prasath VBS, Way SS, Salomonis N, Grimes HL, Lucas D. Zhang J, et al. Among authors: d alessandro a. Nature. 2021 Feb;590(7846):457-462. doi: 10.1038/s41586-021-03201-2. Epub 2021 Feb 10. Nature. 2021. PMID: 33568812 Free PMC article.
This is owing to a lack of strategies for examining myelopoiesis-the differentiation of myeloid progenitors into a large variety of innate immune cells-in situ in the bone marrow. Such strategies are required to understand differentiation and lineage-commitment decisions, …
This is owing to a lack of strategies for examining myelopoiesis-the differentiation of myeloid progenitors into a large variety of innate …
Loss of microglial MCT4 leads to defective synaptic pruning and anxiety-like behavior in mice.
Monsorno K, Ginggen K, Ivanov A, Buckinx A, Lalive AL, Tchenio A, Benson S, Vendrell M, D'Alessandro A, Beule D, Pellerin L, Mameli M, Paolicelli RC. Monsorno K, et al. Among authors: d alessandro a. Nat Commun. 2023 Sep 16;14(1):5749. doi: 10.1038/s41467-023-41502-4. Nat Commun. 2023. PMID: 37717033 Free PMC article.
Microglia, the innate immune cells of the central nervous system, actively participate in brain development by supporting neuronal maturation and refining synaptic connections. ...
Microglia, the innate immune cells of the central nervous system, actively participate in brain development by supporting neuronal ma …
Simultaneous targeting of PD-1 and IL-2Rβγ with radiation therapy inhibits pancreatic cancer growth and metastasis.
Piper M, Hoen M, Darragh LB, Knitz MW, Nguyen D, Gadwa J, Durini G, Karakoc I, Grier A, Neupert B, Van Court B, Abdelazeem KNM, Yu J, Olimpo NA, Corbo S, Ross RB, Pham TT, Joshi M, Kedl RM, Saviola AJ, Amann M, Umaña P, Codarri Deak L, Klein C, D'Alessandro A, Karam SD. Piper M, et al. Among authors: d alessandro a. Cancer Cell. 2023 May 8;41(5):950-969.e6. doi: 10.1016/j.ccell.2023.04.001. Epub 2023 Apr 27. Cancer Cell. 2023. PMID: 37116489 Free PMC article.
In combination with single-dose RT, PD1-IL2v treatment results in a robust, durable expansion of polyfunctional CD8(+) T cells, T cell stemness, tumor-specific memory immune response, natural killer (NK) cell activation, and decreased Tregs. These data show that PD1-IL2v l …
In combination with single-dose RT, PD1-IL2v treatment results in a robust, durable expansion of polyfunctional CD8(+) T cells, T cell stemn …
A distinct metabolic and epigenetic state drives trained immunity in HSC-derived macrophages from autoimmune mice.
Mills TS, Kain B, Burchill MA, Danis E, Lucas ED, Culp-Hill R, Cowan CM, Schleicher WE, Patel SB, Tran BT, Cao R, Goodspeed A, Ferrara S, Bevers S, Jirón Tamburini BA, Roede JR, D'Alessandro A, King KY, Pietras EM. Mills TS, et al. Among authors: d alessandro a. Cell Stem Cell. 2024 Nov 7;31(11):1630-1649.e8. doi: 10.1016/j.stem.2024.09.010. Epub 2024 Oct 15. Cell Stem Cell. 2024. PMID: 39413777 Free PMC article.
Here, we investigate the contribution of long-term hematopoietic stem cells (HSCs(LT)) to trained immunity (TI) in the setting of chronic autoimmune disease. Using a mouse model of systemic lupus erythematosus (SLE), we show that bone marrow-derived macrophages (BMDMs) fro …
Here, we investigate the contribution of long-term hematopoietic stem cells (HSCs(LT)) to trained immunity (TI) in the setting of chr …
Metabolic rewiring induced by ranolazine improves melanoma responses to targeted therapy and immunotherapy.
Redondo-Muñoz M, Rodriguez-Baena FJ, Aldaz P, Caballé-Mestres A, Moncho-Amor V, Otaegi-Ugartemendia M, Carrasco-Garcia E, Olias-Arjona A, Lasheras-Otero I, Santamaria E, Bocanegra A, Chocarro L, Grier A, Dzieciatkowska M M, Bigas C, Martin J, Urdiroz-Urricelqui U, Marzo F, Santamaria E, Kochan G, Escors D, Larrayoz IM, Heyn H, D'Alessandro A, Attolini CS, Matheu A, Wellbrock C, Benitah SA, Sanchez-Laorden B, Arozarena I. Redondo-Muñoz M, et al. Among authors: d alessandro a. Nat Metab. 2023 Sep;5(9):1544-1562. doi: 10.1038/s42255-023-00861-4. Epub 2023 Aug 10. Nat Metab. 2023. PMID: 37563469 Free PMC article.
Combination of RANO with anti-PD-L1 antibodies strongly improves survival by increasing antitumour immune responses. Altogether, we show that RANO increases the efficacy of targeted melanoma therapy through its effects on FAO and the methionine salvage pathway. ...
Combination of RANO with anti-PD-L1 antibodies strongly improves survival by increasing antitumour immune responses. Altogether, we s …
Specialized interferon action in COVID-19.
Galbraith MD, Kinning KT, Sullivan KD, Araya P, Smith KP, Granrath RE, Shaw JR, Baxter R, Jordan KR, Russell S, Dzieciatkowska M, Reisz JA, Gamboni F, Cendali F, Ghosh T, Guo K, Wilson CC, Santiago ML, Monte AA, Bennett TD, Hansen KC, Hsieh EWY, D'Alessandro A, Espinosa JM. Galbraith MD, et al. Among authors: d alessandro a. Proc Natl Acad Sci U S A. 2022 Mar 15;119(11):e2116730119. doi: 10.1073/pnas.2116730119. Proc Natl Acad Sci U S A. 2022. PMID: 35217532 Free PMC article.
The antiviral transcriptional response in circulating immune cells is strongly associated with a specific subset of IFNs, most prominently IFNA2 and IFNG. ...For example, whereas IFNG has the strongest association with C-reactive protein and other immune markers of …
The antiviral transcriptional response in circulating immune cells is strongly associated with a specific subset of IFNs, most promin …
Deleting the mitochondrial respiration negative regulator MCJ enhances the efficacy of CD8+ T cell adoptive therapies in pre-clinical studies.
Wu MH, Valenca-Pereira F, Cendali F, Giddings EL, Pham-Danis C, Yarnell MC, Novak AJ, Brunetti TM, Thompson SB, Henao-Mejia J, Flavell RA, D'Alessandro A, Kohler ME, Rincon M. Wu MH, et al. Among authors: d alessandro a. Nat Commun. 2024 May 24;15(1):4444. doi: 10.1038/s41467-024-48653-y. Nat Commun. 2024. PMID: 38789421 Free PMC article.
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