Effect of Sunscreen Application Under Maximal Use Conditions on Plasma Concentration of Sunscreen Active Ingredients: A Randomized Clinical Trial.
Matta MK, Zusterzeel R, Pilli NR, Patel V, Volpe DA, Florian J, Oh L, Bashaw E, Zineh I, Sanabria C, Kemp S, Godfrey A, Adah S, Coelho S, Wang J, Furlong LA, Ganley C, Michele T, Strauss DG.
Matta MK, et al.
JAMA. 2019 Jun 4;321(21):2082-2091. doi: 10.1001/jama.2019.5586.
JAMA. 2019.
PMID: 31058986
Free PMC article.
Clinical Trial.
IMPORTANCE: The US Food and Drug Administration (FDA) has provided guidance that sunscreen active ingredients with systemic absorption greater than 0.5 ng/mL or with safety concerns should undergo nonclinical toxicology assessment including systemic carcinogenicity and additional …
IMPORTANCE: The US Food and Drug Administration (FDA) has provided guidance that sunscreen active ingredients with systemic absorption great …