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Page 1
Phage Therapy for Antibiotic-Resistant Bacterial Infections.
Hatfull GF, Dedrick RM, Schooley RT. Hatfull GF, et al. Annu Rev Med. 2022 Jan 27;73:197-211. doi: 10.1146/annurev-med-080219-122208. Epub 2021 Aug 24. Annu Rev Med. 2022. PMID: 34428079 Review.
The therapeutic use of bacteriophages has long been considered, with numerous anecdotal reports of success. Interest in phage therapy has been renewed by recent clinical successes in case studies with personalized phage cocktails, and several clinical trials are in …
The therapeutic use of bacteriophages has long been considered, with numerous anecdotal reports of success. Interest in phage ther …
Bacteriophages and its applications: an overview.
Sharma S, Chatterjee S, Datta S, Prasad R, Dubey D, Prasad RK, Vairale MG. Sharma S, et al. Folia Microbiol (Praha). 2017 Jan;62(1):17-55. doi: 10.1007/s12223-016-0471-x. Epub 2016 Oct 8. Folia Microbiol (Praha). 2017. PMID: 27718043 Review.
However, due to recent emergence of bacterial resistance on antibiotics, applications of phage (phage therapy) become an inevitable option of research. Phage particles become popular as a biotechnological tool and treatment of pathogenic bacteria in a range of appli …
However, due to recent emergence of bacterial resistance on antibiotics, applications of phage (phage therapy) become an inevi …
Phage Therapy: Going Temperate?
Monteiro R, Pires DP, Costa AR, Azeredo J. Monteiro R, et al. Trends Microbiol. 2019 Apr;27(4):368-378. doi: 10.1016/j.tim.2018.10.008. Epub 2018 Nov 19. Trends Microbiol. 2019. PMID: 30466900 Review.
Strictly lytic phages have been consensually preferred for phage therapy purposes. In contrast, temperate phages have been avoided due to an inherent capacity to mediate transfer of genes between bacteria by specialized transduction - an event that may increase bact …
Strictly lytic phages have been consensually preferred for phage therapy purposes. In contrast, temperate phages have been avo …
Bacteria-phage interactions in natural environments.
Díaz-Muñoz SL, Koskella B. Díaz-Muñoz SL, et al. Adv Appl Microbiol. 2014;89:135-83. doi: 10.1016/B978-0-12-800259-9.00004-4. Adv Appl Microbiol. 2014. PMID: 25131402 Review.
Mechanisms and clinical importance of bacteriophage resistance.
Egido JE, Costa AR, Aparicio-Maldonado C, Haas PJ, Brouns SJJ. Egido JE, et al. FEMS Microbiol Rev. 2022 Feb 9;46(1):fuab048. doi: 10.1093/femsre/fuab048. FEMS Microbiol Rev. 2022. PMID: 34558600 Free PMC article. Review.
Enhancing phage therapy through synthetic biology and genome engineering.
Lenneman BR, Fernbach J, Loessner MJ, Lu TK, Kilcher S. Lenneman BR, et al. Curr Opin Biotechnol. 2021 Apr;68:151-159. doi: 10.1016/j.copbio.2020.11.003. Epub 2020 Dec 10. Curr Opin Biotechnol. 2021. PMID: 33310655 Free PMC article. Review.
The antimicrobial and therapeutic efficacy of bacteriophages is currently limited, mostly due to rapid emergence of phage-resistance and the inability of most phage isolates to bind and infect a broad range of clinical strains. Here, we discuss how phage therapy can …
The antimicrobial and therapeutic efficacy of bacteriophages is currently limited, mostly due to rapid emergence of phage-resistance and the …
Developing Phage Therapy That Overcomes the Evolution of Bacterial Resistance.
Oromí-Bosch A, Antani JD, Turner PE. Oromí-Bosch A, et al. Annu Rev Virol. 2023 Sep 29;10(1):503-524. doi: 10.1146/annurev-virology-012423-110530. Epub 2023 Jun 2. Annu Rev Virol. 2023. PMID: 37268007 Free article. Review.
However, a perpetual challenge for developing generalized phage therapy is the expectation that viruses will exert selection for target bacteria to deploy defenses against virus attack, causing evolution of phage resistance during patient treatment. Here we review t …
However, a perpetual challenge for developing generalized phage therapy is the expectation that viruses will exert selection f …
Phage Therapy in the Resistance Era: Where Do We Stand and Where Are We Going?
Luong T, Salabarria AC, Roach DR. Luong T, et al. Clin Ther. 2020 Sep;42(9):1659-1680. doi: 10.1016/j.clinthera.2020.07.014. Epub 2020 Aug 31. Clin Ther. 2020. PMID: 32883528 Free article. Review.
This review summarizes recent phage therapy clinical trials and patient cases and outlines the fundamentals behind phage treatment strategies under development, mainly through bench-to-bedside approaches. We discuss the challenges that remain in phage ther …
This review summarizes recent phage therapy clinical trials and patient cases and outlines the fundamentals behind phage treat …
Biotechnological applications of bacteriophages: State of the art.
Harada LK, Silva EC, Campos WF, Del Fiol FS, Vila M, Dąbrowska K, Krylov VN, Balcão VM. Harada LK, et al. Microbiol Res. 2018 Jul-Aug;212-213:38-58. doi: 10.1016/j.micres.2018.04.007. Epub 2018 Apr 30. Microbiol Res. 2018. PMID: 29853167 Free article. Review.
2,271 results