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1990 3
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2002 5
2003 6
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2005 9
2006 13
2007 11
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2009 11
2010 17
2011 13
2012 16
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505 results

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Page 1
RNAi-based modulation of IFN-γ signaling in skin.
Tang Q, Sousa J, Echeverria D, Fan X, Hsueh YC, Afshari K, MeHugh N, Cooper DA, Vangjeli L, Monopoli K, Okamura K, Biscans A, Clauss A, Harris JE, Khvorova A. Tang Q, et al. Mol Ther. 2022 Aug 3;30(8):2709-2721. doi: 10.1016/j.ymthe.2022.04.019. Epub 2022 Apr 27. Mol Ther. 2022. PMID: 35477658 Free PMC article.
Here, we identify fully chemically modified small interfering RNAs (siRNAs) that silence the ligand binding chain of the IFN-gamma receptor (IFNGR1), for the modulation of IFN-gamma signaling. Conjugating these siRNAs to docosanoic acid (DCA) enables productive deli …
Here, we identify fully chemically modified small interfering RNAs (siRNAs) that silence the ligand binding chain of the IFN-gamma receptor …
Behenic acid is a cholesterol-raising saturated fatty acid in humans.
Cater NB, Denke MA. Cater NB, et al. Am J Clin Nutr. 2001 Jan;73(1):41-4. doi: 10.1093/ajcn/73.1.41. Am J Clin Nutr. 2001. PMID: 11124748 Clinical Trial.
BACKGROUND: Dietary behenic acid (22:0) is poorly absorbed. Because of its low bioavailability compared with other fatty acids and because of its very long chain length, the effect of dietary behenic acid (behenate) on serum lipid concentrations in hum …
BACKGROUND: Dietary behenic acid (22:0) is poorly absorbed. Because of its low bioavailability compared with other fatty acids …
Ketogenic diet aggravates colitis, impairs intestinal barrier and alters gut microbiota and metabolism in DSS-induced mice.
Li S, Zhuge A, Wang K, Lv L, Bian X, Yang L, Xia J, Jiang X, Wu W, Wang S, Wang Q, Li L. Li S, et al. Food Funct. 2021 Oct 19;12(20):10210-10225. doi: 10.1039/d1fo02288a. Food Funct. 2021. PMID: 34542110
Ketogenic diet also modified gut metabolism, increasing metabolites in the bile secretion such as ouabain, taurochenodeoxycholic acid, quinine, cholic acid and glycocholic acid, and decreasing metabolites associated with the biosynthesis of unsaturated fatty acids including stear …
Ketogenic diet also modified gut metabolism, increasing metabolites in the bile secretion such as ouabain, taurochenodeoxycholic acid, quini …
Behenic acid alleviates inflammation and insulin resistance in gestational diabetes mellitus by regulating TLR4/NF-kappaB signaling pathway.
Liu K, Gu Y, Pan X, Chen S, Cheng J, Zhang L, Cao M. Liu K, et al. iScience. 2024 Sep 24;27(10):111019. doi: 10.1016/j.isci.2024.111019. eCollection 2024 Oct 18. iScience. 2024. PMID: 39429784 Free PMC article.
The objective of this study was to investigate the impact of behenic acid (BA) on glucose metabolism, inflammation, and insulin resistance in GDM mice, and to elucidate the underlying molecular mechanism. ...
The objective of this study was to investigate the impact of behenic acid (BA) on glucose metabolism, inflammation, and insuli …
Discovering the direct relations between nutrients and epigenetic ageing.
Grootswagers P, Bach D, Biemans Y, Behrouzi P, Horvath S, Kramer CS, Liu S, Manson JE, Shadyab AH, Stewart JD, Whitsel E, Yang B, de Groot L. Grootswagers P, et al. J Nutr Health Aging. 2024 Sep;28(9):100324. doi: 10.1016/j.jnha.2024.100324. Epub 2024 Jul 26. J Nutr Health Aging. 2024. PMID: 39067141 Free article.
In contrast, increased intakes of added sugar, gondoic acid, behenic acid, arachidonic acid, vitamin A and ash were associated with accelerated epigenetic ageing in postmenopausal women. ...
In contrast, increased intakes of added sugar, gondoic acid, behenic acid, arachidonic acid, vitamin A and ash were associated …
Short-term treatment with high dose liraglutide improves lipid and lipoprotein profile and changes hormonal mediators of lipid metabolism in obese patients with no overt type 2 diabetes mellitus: a randomized, placebo-controlled, cross-over, double-blind clinical trial.
Peradze N, Farr OM, Perakakis N, Lázaro I, Sala-Vila A, Mantzoros CS. Peradze N, et al. Cardiovasc Diabetol. 2019 Oct 31;18(1):141. doi: 10.1186/s12933-019-0945-7. Cardiovasc Diabetol. 2019. PMID: 31672146 Free PMC article. Clinical Trial.
Similarly, reductions in number of small and medium size LDL particles and in their total lipid concentration were observed with liraglutide and partially weight-loss related. Tyrosine levels were reduced and behenic acid levels were increased whereas only minor cha …
Similarly, reductions in number of small and medium size LDL particles and in their total lipid concentration were observed with liraglutide …
Serum Fatty Acid Profiles and Neurofilament Light Chain Levels in the General Population.
Lv X, Zhao Q, Liu Q, Ji Q, Huang X, Zhou L, Hu Z, Liu M, Zhan Y. Lv X, et al. J Nutr. 2024 Oct;154(10):3070-3078. doi: 10.1016/j.tjnut.2024.07.007. Epub 2024 Jul 14. J Nutr. 2024. PMID: 39004226 Free article.
RESULTS: The analysis revealed that certain fatty acids exhibited distinct associations with serum NfL levels. Notably, docosanoic acid (22:0) and tricosanoic acid (C23:0) were found to be inversely associated with serum NfL levels (beta = -0.280, 95% confidence int …
RESULTS: The analysis revealed that certain fatty acids exhibited distinct associations with serum NfL levels. Notably, docosanoic …
Very long-chain saturated fatty acids and diabetes and cardiovascular disease.
Lemaitre RN, King IB. Lemaitre RN, et al. Curr Opin Lipidol. 2022 Feb 1;33(1):76-82. doi: 10.1097/MOL.0000000000000806. Curr Opin Lipidol. 2022. PMID: 34907969 Free PMC article. Review.
PURPOSE OF REVIEW: In contrast to other saturated fatty acids, very long-chain saturated fatty acids (VLSFAs) have received limited attention The purpose of this review is to summarize the associations of VLSFAs, including arachidic acid, behenic acid, and lignoceri …
PURPOSE OF REVIEW: In contrast to other saturated fatty acids, very long-chain saturated fatty acids (VLSFAs) have received limited attentio …
505 results