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5,168 results

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Quoted phrase not found in phrase index: "leucoline"
Page 1
Biologically active isoquinoline alkaloids covering 2014-2018.
Shang XF, Yang CJ, Morris-Natschke SL, Li JC, Yin XD, Liu YQ, Guo X, Peng JW, Goto M, Zhang JY, Lee KH. Shang XF, et al. Med Res Rev. 2020 Nov;40(6):2212-2289. doi: 10.1002/med.21703. Epub 2020 Jul 29. Med Res Rev. 2020. PMID: 32729169 Free PMC article. Review.
Isoquinoline alkaloids, an important class of N-based heterocyclic compounds, have attracted considerable attention from researchers worldwide since the early 19th century. ...This review should provide new indications or directions for the discovery of new and better drug …
Isoquinoline alkaloids, an important class of N-based heterocyclic compounds, have attracted considerable attention from researchers …
Biologically active isoquinoline alkaloids covering 2019-2022.
Wang D, Qin L, Jing C, Wang G, Zhou H, Deng P, Zhang S, Wang Y, Ding Y, Zhang Z, Wu Z, Liu Y. Wang D, et al. Bioorg Chem. 2024 Apr;145:107252. doi: 10.1016/j.bioorg.2024.107252. Epub 2024 Mar 1. Bioorg Chem. 2024. PMID: 38437763 Review.
Isoquinoline alkaloids are an important class of natural products that are abundant in the plant kingdom and exhibit a wide range of structural diversity and biological activities. ...This study provides a clear direction for the rational development and utilization of …
Isoquinoline alkaloids are an important class of natural products that are abundant in the plant kingdom and exhibit a wide range of …
Trans-1,2,3,5,6,10b-hexahydro-6-[4-([(18)F]fluoroethylthio)-phenyl]pyrrolo-[2,1-a]-isoquinoline.
Chopra A. Chopra A. 2007 May 29 [updated 2007 Jun 27]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. 2007 May 29 [updated 2007 Jun 27]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. PMID: 20641850 Free Books & Documents. Review.
Among these, trans-1,2,3,5,6,10b-hexahydro-6-[4-(methylthio)-phenyl]pyrrolo-[2,1-a]-isoquinoline ([(11)C]McN5652-Z), a highly potent serotonin transport (SERT) blocker was developed for imaging and is still used for the evaluation of this system (7, 8). ...For this an S-[( …
Among these, trans-1,2,3,5,6,10b-hexahydro-6-[4-(methylthio)-phenyl]pyrrolo-[2,1-a]-isoquinoline ([(11)C]McN5652-Z), a highly potent …
Isoquinolines: Important Cores in Many Marketed and Clinical Drugs.
Luo C, Ampomah-Wireko M, Wang H, Wu C, Wang Q, Zhang H, Cao Y. Luo C, et al. Anticancer Agents Med Chem. 2021;21(7):811-824. doi: 10.2174/1871520620666200424132248. Anticancer Agents Med Chem. 2021. PMID: 32329698 Review.
BACKGROUND: Isoquinoline analogs are an important, structurally diverse class of compounds that are extensively used as pharmaceuticals. Derivatives containing the isoquinoline scaffold have become a focus of therapeutic research because of their wide range of biolo …
BACKGROUND: Isoquinoline analogs are an important, structurally diverse class of compounds that are extensively used as pharmaceutica …
Rationalization of Benzazole-2-carboxylate versus Benzazine-3-one/Benzazine-2,3-dione Selectivity Switch during Cyclocondensation of 2-Aminothiophenols/Phenols/Anilines with 1,2-Biselectrophiles in Aqueous Medium.
Dhameliya TM, Chourasiya SS, Mishra E, Jadhavar PS, Bharatam PV, Chakraborti AK. Dhameliya TM, et al. J Org Chem. 2017 Oct 6;82(19):10077-10091. doi: 10.1021/acs.joc.7b01548. Epub 2017 Sep 15. J Org Chem. 2017. PMID: 28846411
On the other hand, the reaction of 2-aminophenols/anilines produced the corresponding benzazine-3-ones or benzazine-2,3-diones via the 6-exo-trig process in compliance with Baldwin's rule. The mechanistic insights of these cyclocondensation reactions using the hard- …
On the other hand, the reaction of 2-aminophenols/anilines produced the corresponding benzazine-3-ones or benzazine-2,3-diones …
Research Progress on Neuroprotective Effects of Isoquinoline Alkaloids.
Li J, Wu Y, Dong S, Yu Y, Wu Y, Xiang B, Li Q. Li J, et al. Molecules. 2023 Jun 16;28(12):4797. doi: 10.3390/molecules28124797. Molecules. 2023. PMID: 37375352 Free PMC article. Review.
This paper provides a comprehensive review of the active components found in isoquinoline alkaloids that have neuroprotective effects. It thoroughly explains the various mechanisms behind the neuroprotective effects of isoquinoline alkaloids and summarizes their com …
This paper provides a comprehensive review of the active components found in isoquinoline alkaloids that have neuroprotective effects …
The Anticancer Effect of Natural Plant Alkaloid Isoquinolines.
Yun D, Yoon SY, Park SJ, Park YJ. Yun D, et al. Int J Mol Sci. 2021 Feb 6;22(4):1653. doi: 10.3390/ijms22041653. Int J Mol Sci. 2021. PMID: 33562110 Free PMC article. Review.
Isoquinoline alkaloids-enriched herbal plants have been used as traditional folk medicine for their anti-inflammatory, antimicrobial, and analgesic effects. ...While the molecular mechanisms of these effects are not fully understood, it has been suggested that binding to n …
Isoquinoline alkaloids-enriched herbal plants have been used as traditional folk medicine for their anti-inflammatory, antimicrobial, …
An Overview on the Synthesis of Lamellarins and Related Compounds with Biological Interest.
Mitsiou VM, Antonaki AN, Douka MD, Litinas KE. Mitsiou VM, et al. Molecules. 2024 Aug 26;29(17):4032. doi: 10.3390/molecules29174032. Molecules. 2024. PMID: 39274880 Free PMC article. Review.
Initially, pyrrole derivatives are the starting or intermediate compounds, and then they are fused to isoquinoline or a coumarin moiety. Second, isoquinoline is the starting compound fused to an indole moiety. In the last route, coumarins are the starting compounds, …
Initially, pyrrole derivatives are the starting or intermediate compounds, and then they are fused to isoquinoline or a coumarin moie …
Isolation, biological activity, and synthesis of isoquinoline alkaloids.
Yang X, Miao X, Dai L, Guo X, Jenis J, Zhang J, Shang X. Yang X, et al. Nat Prod Rep. 2024 Nov 13;41(11):1652-1722. doi: 10.1039/d4np00023d. Nat Prod Rep. 2024. PMID: 39355982 Review.
The total synthesis of more than nine classes of isoquinoline alkaloids is presented, and thirteen compounds constitute the first total synthesis. This survey provides new indications or possibilities for the discovery of new drugs from the original naturally occurring …
The total synthesis of more than nine classes of isoquinoline alkaloids is presented, and thirteen compounds constitute the first tot …
The pyrrolo[2,1-a]isoquinoline alkaloids.
Pässler U, Knölker HJ. Pässler U, et al. Alkaloids Chem Biol. 2011;70:79-151. doi: 10.1016/b978-0-12-391426-2.00002-5. Alkaloids Chem Biol. 2011. PMID: 22308756 Review.
The present chapter describes isolation, biogenetic proposals, and syntheses of the natural products 1-4 and 10-11 with a pyrrolo[2,1-a]-isoquinoline framework. Moreover, the syntheses of some structural analogs are discussed. ...Only one total synthesis has been reported …
The present chapter describes isolation, biogenetic proposals, and syntheses of the natural products 1-4 and 10-11 with a pyrrolo[2,1-a]- …
5,168 results