Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

MyNCBI Filters
Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1991 2
1992 7
1993 14
1994 31
1995 40
1996 76
1997 124
1998 180
1999 293
2000 334
2001 441
2002 505
2003 551
2004 594
2005 656
2006 703
2007 810
2008 950
2009 1003
2010 1082
2011 1260
2012 1351
2013 1377
2014 1443
2015 1468
2016 1501
2017 1396
2018 1310
2019 670
2020 12
Text availability
Article attribute
Article type
Publication date

Search Results

17,989 results
Results by year
Filters applied: . Clear all
Page 1
Wnt/Beta-Catenin Signaling and Prostate Cancer Therapy Resistance.
Yeh Y, et al. Adv Exp Med Biol 2019 - Review. PMID 31900917
Wnt/β-Catenin signaling is frequently activated in late stage PCa and contributes to the development of therapy resistance. Although activating mutations in the Wnt/β-Catenin pathway are not common in primary PCa, this signaling cascade can be activated through other mechanisms in late stage PCa, including cross talk with other signaling pathways, growth factors and cytokines produced by the damaged tumor microenvironment, release of the co-activator β-Catenin from sequestration after inhibition of androgen receptor (AR) signaling, altered expression of Wnt ligands and factors that modulate the Wnt signaling, and therapy-induced cellular senescence. ...These important roles of Wnt/β-Catenin signaling in PCa progression underscore the need for the development of drugs targeting this pathway to treat therapy-resistant PCa....
Wnt/β-Catenin signaling is frequently activated in late stage PCa and contributes to the development of therapy resistance. Although …
WNT/β-catenin Pathway Activation Correlates with Immune Exclusion across Human Cancers.
Luke JJ, et al. Clin Cancer Res 2019. PMID 30635339 Free PMC article.
Activation of WNT/β-catenin signaling was inferred using three approaches: somatic mutations or somatic copy number alterations (SCNA) in β-catenin signaling elements including CTNNB1, APC, APC2, AXIN1, and AXIN2; pathway prediction from RNA-sequencing gene expression; and inverse correlation of β-catenin protein levels with the T-cell-inflamed gene expression signature. ...This included target molecule expression from somatic mutations and/or SCNAs of β-catenin signaling elements (19 tumors, 61%), pathway analysis (14 tumors, 45%), and increased β-catenin protein levels (20 tumors, 65%). ...
Activation of WNT/β-catenin signaling was inferred using three approaches: somatic mutations or somatic copy number alterations (SCNA …
Divergent Axin and GSK-3 paralogs in the beta-catenin destruction complexes of tapeworms.
Montagne J, et al. Dev Genes Evol 2019. PMID 31041506
The Wnt/beta-catenin pathway has many key roles in the development of animals, including a conserved and central role in the specification of the primary (antero-posterior) body axis. ...However, their downstream signaling components for Wnt/beta-catenin signaling have not been characterized. In this work, we have studied the core components of the beta-catenin destruction complex of the human pathogen Echinococcus multilocularis, the causative agent of alveolar echinococcosis. ...
The Wnt/beta-catenin pathway has many key roles in the development of animals, including a conserved and central role in the s …
Translation of the circular RNA circβ-catenin promotes liver cancer cell growth through activation of the Wnt pathway.
Liang WC, et al. Genome Biol 2019. PMID 31027518 Free PMC article.
In the current study, we evaluate the function of a novel circRNA derived from the β-catenin gene locus, circβ-catenin. RESULTS: Circβ-catenin is predominantly localized in the cytoplasm and displays resistance to RNase-R treatment. ...We show that circβ-catenin affects a wide spectrum of Wnt pathway-related genes, and furthermore, circβ-catenin produces a novel 370-amino acid β-catenin isoform that uses the start codon as the linear β-catenin mRNA transcript and translation is terminated at a new stop codon created by circularization. ...
In the current study, we evaluate the function of a novel circRNA derived from the β-catenin gene locus, circβ-catenin. RESULT …
The 308-nm excimer laser stimulates melanogenesis via the wnt/β-Catenin signaling pathway in B16 cells.
Li L, et al. J Dermatolog Treat 2019. PMID 30661431
The expression of tyrosinase, MITF, Wnt3α and β-catenin was analyzed by Western blotting. Results: Cell irradiation with the 308-nm excimer laser not only significantly elevated the melanin content (p < .01) but also stimulated the activity of tyrosinase (p < .01). ...Increased Wnt3α and β-catenin expression was observed by Western blot analysis. Conclusion: Activation of the Wnt/β-catenin pathway likely led to the activation of MITF and tyrosinase transcription, as well as, the subsequent induction of melanin synthesis....
The expression of tyrosinase, MITF, Wnt3α and β-catenin was analyzed by Western blotting. Results: Cell irradiation with the 308-nm e …
USP7 inhibits Wnt/β-catenin signaling through promoting stabilization of Axin.
Ji L, et al. Nat Commun 2019. PMID 31519875 Free PMC article.
Axin is a key scaffolding protein responsible for the formation of the β-catenin destruction complex. Stability of Axin protein is regulated by the ubiquitin-proteasome system, and modulation of cellular concentration of Axin protein has a profound effect on Wnt/β-catenin signaling. ...Here, we identify USP7 as a potent negative regulator of Wnt/β-catenin signaling through CRISPR screens. Genetic ablation or pharmacological inhibition of USP7 robustly increases Wnt/β-catenin signaling in multiple cellular systems. ...
Axin is a key scaffolding protein responsible for the formation of the β-catenin destruction complex. Stability of Axin protein is re …
β-Catenin is essential for differentiation of primary myoblasts via cooperation with MyoD and α-catenin.
Cui S, et al. Development 2019. PMID 30683662 Free PMC article.
Using CRISPR-generated β-catenin-null primary adult mouse myoblasts, we found that β-catenin was essential for morphological differentiation and timely deployment of the myogenic gene program. ...We also showed that interaction of β-catenin with α-catenin was important for efficient differentiation. Overall the study suggests dual roles for β-catenin: a TCF/LEF-independent nuclear function that coordinates an extensive network of myogenic genes in cooperation with MyoD; and an α-catenin-dependent membrane function that helps control cell-cell interactions. β-Catenin-TCF/LEF complexes may function primarily in feedback regulation to control levels of β-catenin and thus prevent precocious/excessive myoblast fusion....
Using CRISPR-generated β-catenin-null primary adult mouse myoblasts, we found that β-catenin was essential for morphological d …
A ZNRF3-dependent Wnt/β-catenin signaling gradient is required for adrenal homeostasis.
Basham KJ, et al. Genes Dev 2019. PMID 30692207 Free PMC article.
Furthermore, we discovered a Wnt/β-catenin signaling gradient in the adrenal cortex that is disrupted upon loss of ZNRF3. Unlike β-catenin gain-of-function models, which induce high Wnt/β-catenin activation and expansion of the peripheral cortex, ZNRF3 loss triggers activation of moderate-level Wnt/β-catenin signaling that drives proliferative expansion of only the histologically and functionally distinct inner cortex. Genetically reducing β-catenin dosage significantly reverses the ZNRF3-deficient phenotype. Thus, homeostatic maintenance of the adrenal cortex is dependent on varying levels of Wnt/β-catenin activation, which is regulated by ZNRF3....
Furthermore, we discovered a Wnt/β-catenin signaling gradient in the adrenal cortex that is disrupted upon loss of ZNRF3. Unlike β- …
Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes.
Shooshtarizadeh P, et al. Nat Commun 2019. PMID 30894540 Free PMC article.
Here we show that Gfi1b forms complexes with β-catenin, its co-factors Pontin52, CHD8, TLE3 and CtBP1 and regulates Wnt/β-catenin-dependent gene expression. ...This requires interaction between Gfi1b and LSD1 and suggests that a tripartite β-catenin/Gfi1b/LSD1 complex exists, which regulates Wnt/β-catenin target genes. ...
Here we show that Gfi1b forms complexes with β-catenin, its co-factors Pontin52, CHD8, TLE3 and CtBP1 and regulates Wnt/β-catenin
Role of β-Catenin Activation Levels and Fluctuations in Controlling Cell Fate.
Pedone E and Marucci L. Genes (Basel) 2019 - Review. PMID 30823613 Free PMC article.
The activity of the Wnt/β-catenin pathway and the temporal dynamics of its effector β-catenin are tightly controlled by complex regulations. ...Possible mechanisms originating Wnt/β-catenin dynamic behaviors and consequently driving different cellular responses are also reviewed, and new avenues for future research are suggested....
The activity of the Wnt/β-catenin pathway and the temporal dynamics of its effector β-catenin are tightly controlled by comple …
17,989 results
Jump to page
Feedback