Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

MyNCBI Filters
Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2002 1
2003 1
2004 9
2005 203
2006 519
2007 629
2008 771
2009 818
2010 914
2011 1075
2012 1140
2013 1189
2014 1212
2015 1182
2016 1213
2017 1111
2018 1011
2019 512
2020 9
Text availability
Article attribute
Article type
Publication date

Search Results

11,791 results
Results by year
Filters applied: . Clear all
Page 1
Wnt/Beta-Catenin Signaling Regulation and a Role for Biomolecular Condensates.
Schaefer KN and Peifer M. Dev Cell 2019 - Review. PMID 30782412 Free PMC article.
Wnt/β-Catenin signaling plays key roles in tissue homeostasis and cell fate decisions in embryonic and post-embryonic development across the animal kingdom. ...
Wnt/β-Catenin signaling plays key roles in tissue homeostasis and cell fate decisions in embryonic and post-embryonic development acr …
Wnt/β-catenin signaling and disease.
Clevers H and Nusse R. Cell 2012 - Review. PMID 22682243 Free article.
In this Review, we provide an update of the core Wnt/β-catenin signaling pathway, discuss how its various components contribute to disease, and pose outstanding questions to be addressed in the future....
In this Review, we provide an update of the core Wnt/β-catenin signaling pathway, discuss how its various components contribute to di …
Dlg1 activates beta-catenin signaling to regulate retinal angiogenesis and the blood-retina and blood-brain barriers.
Cho C, et al. Elife 2019. PMID 31066677 Free PMC article.
EC-specific loss of Dlg1 produces a retinal vascular phenotype that closely matches the phenotype associated with reduced beta-catenin signaling, synergizes with genetically-directed reductions in beta-catenin signaling components, and can be rescued by stabilizing beta-catenin in ECs. ...These data expand the repertoire of Dlg/MAGUK family functions to include a role in beta-catenin signaling, and they suggest that proteins other than Frizzled receptors interact with Dlg1 to enhance beta-catenin signaling....
EC-specific loss of Dlg1 produces a retinal vascular phenotype that closely matches the phenotype associated with reduced beta-cat
Interactions Between the Canonical WNT/Beta-Catenin Pathway and PPAR Gamma on Neuroinflammation, Demyelination, and Remyelination in Multiple Sclerosis.
Vallée A, et al. Cell Mol Neurobiol 2018 - Review. PMID 28905149
The immune response is regulated by WNT/beta-catenin pathway in MS. Activated NF-kappaB, a major effector of neuroinflammation, and upregulated canonical WNT/beta-catenin pathway positively regulate each other. ...PPAR gamma activation can inhibit NF-kappaB, and can also downregulate the WNT/beta-catenin pathway. PPAR gamma and canonical WNT/beta-catenin pathway act in an opposite manner. ...
The immune response is regulated by WNT/beta-catenin pathway in MS. Activated NF-kappaB, a major effector of neuroinflammation …
β-Catenin regulation of farnesoid X receptor signaling and bile acid metabolism during murine cholestasis.
Thompson MD, et al. Hepatology 2018. PMID 28714273 Free PMC article.
Conversely, accumulation of β-catenin sequesters FXR, thus inhibiting its activation. Finally, exogenous suppression of β-catenin expression during cholestatic injury reduces β-catenin/FXR complex activation of FXR to decrease total BA and alleviate hepatic injury. CONCLUSION: We have identified an FXR/β-catenin interaction whose modulation through β-catenin suppression promotes FXR activation and decreases hepatic BAs, which may provide unique therapeutic opportunities in cholestatic liver diseases. ...
Conversely, accumulation of β-catenin sequesters FXR, thus inhibiting its activation. Finally, exogenous suppression of β-catenin
The many faces and functions of β-catenin.
Valenta T, et al. EMBO J 2012 - Review. PMID 22617422 Free PMC article.
Intense research into the life of β-catenin has revealed a complex picture. Here, we try to capture the state of the art: we try to summarize and make some sense of the processes that regulate β-catenin, as well as the plethora of β-catenin binding partners. One focus will be the interaction of β-catenin with different transcription factors and the potential implications of these interactions for direct cross-talk between β-catenin and non-Wnt signalling pathways....
Intense research into the life of β-catenin has revealed a complex picture. Here, we try to capture the state of the art: we try to s …
Wnt signaling in development and tissue homeostasis
Steinhart Z and Angers S. Development 2018 - Review. PMID 29884654 Free article.
Genetic or epigenetic events leading to hypo- or hyper-activation of the Wnt-β-catenin signaling cascade have also been associated with human diseases such as cancer. ...Here, and in the accompanying poster, we provide an overview of Wnt-β-catenin signaling and briefly highlight its key functions during development and adult tissue homeostasis....
Genetic or epigenetic events leading to hypo- or hyper-activation of the Wnt-β-catenin signaling cascade have also been associated wi …
Is β-Catenin a Druggable Target for Cancer Therapy?
Cui C, et al. Trends Biochem Sci 2018 - Review. PMID 30056837
Mutations of canonical Wnt signaling pathway genes frequently occur in cancer and lead to abnormal accumulation of the key effector β-catenin. ...Here, we review Wnt inhibitors with a focus on small molecules that directly bind β-catenin, discuss the druggability of β-catenin, and why it has rarely been targeted, especially in the cellular context. ...
Mutations of canonical Wnt signaling pathway genes frequently occur in cancer and lead to abnormal accumulation of the key effector β-cat
Characterization of a beta-catenin nuclear localization defect in MCF-7 breast cancer cells.
Jamieson C, et al. Exp Cell Res 2016. PMID 26844628
Beta-catenin plays a key role in transducing Wnt signals from the plasma membrane to the nucleus. Here we characterize an unusual subcellular distribution of beta-catenin in MCF-7 breast cancer cells, wherein beta-catenin localizes to the cytoplasm and membrane but atypically did not relocate to the nucleus after Wnt treatment. ...The reconstitution of LEF-1 or TCF4 expression rescued nuclear localization of beta-catenin in Wnt treated cells. In the cytoplasm, beta-catenin accumulated in recycling endosomes, golgi and beta-COP-positive coatomer complexes. ...
Beta-catenin plays a key role in transducing Wnt signals from the plasma membrane to the nucleus. Here we characterize an unus
Wnt/β-catenin Signaling in Osteoarthritis and in Other Forms of Arthritis.
Zhou Y, et al. Curr Rheumatol Rep 2017 - Review. PMID 28752488 Free PMC article.
The canonical wingless/integrated (Wnt)/β-catenin signaling pathway could play a unique role in the pathogenesis of arthritis. ...Mediators and downstream effectors of Wnt/β-catenin signaling are increased in OA as well other forms of arthritis, including DISH and SpA. ...
The canonical wingless/integrated (Wnt)/β-catenin signaling pathway could play a unique role in the pathogenesis of arthritis. ...Med …
11,791 results
Jump to page
Feedback