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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1948 1
1957 2
1959 3
1965 1
1971 2
1972 13
1973 15
1974 24
1975 17
1976 20
1977 32
1978 22
1979 56
1980 54
1981 89
1982 107
1983 66
1984 76
1985 100
1986 99
1987 97
1988 93
1989 72
1990 77
1991 71
1992 70
1993 62
1994 52
1995 87
1996 62
1997 83
1998 86
1999 100
2000 106
2001 109
2002 164
2003 144
2004 191
2005 240
2006 252
2007 269
2008 315
2009 276
2010 274
2011 342
2012 398
2013 333
2014 359
2015 352
2016 367
2017 359
2018 276
2019 119
2020 1
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6,460 results
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Page 1
Cross-reactivity in β-Lactam Allergy
Zagursky RJ and Pichichero ME. J Allergy Clin Immunol Pract 2018 - Review. PMID 29017833
Therapeutic Drug Monitoring of Beta-Lactams and Other Antibiotics in the Intensive Care Unit: Which Agents, Which Patients and Which Infections?
Muller AE, et al. Drugs 2018 - Review. PMID 29476349
Now TDM is becoming more widespread, particularly for the beta-lactam antibiotics, a class historically thought to have a wide therapeutic range. We review the basic requirements, indications, and targets for effective TDM of the glycopeptides, aminoglycosides, quinolones and beta-lactam antibiotics in the adult intensive-care setting, with a special focus on TDM of the beta-lactam antibiotics, the most widely used antibiotic class....
Now TDM is becoming more widespread, particularly for the beta-lactam antibiotics, a class historically thought to have a wide therap …
Pharmacokinetics-pharmacodynamics issues relevant for the clinical use of beta-lactam antibiotics in critically ill patients.
Veiga RP and Paiva JA. Crit Care 2018 - Review. PMID 30244674 Free PMC article.
Antimicrobials are among the most important and commonly prescribed drugs in the management of critically ill patients and beta-lactams are the most common antibiotic class used. Critically ill patient's pathophysiological factors lead to altered pharmacokinetics and pharmacodynamics of beta-lactams.A comprehensive bibliographic search in PubMed database of all English language articles published from January 2000 to December 2017 was performed, allowing the selection of articles addressing the pharmacokinetics or pharmacodynamics of beta-lactam antibiotics in critically ill patients.In critically ill patients, several factors may increase volume of distribution and enhance renal clearance, inducing high intra- and inter-patient variability in beta-lactam concentration and promoting the risk of antibiotic underdosing. ...
Antimicrobials are among the most important and commonly prescribed drugs in the management of critically ill patients and beta-la
Beta-lactams in continuous infusion for Gram-negative bacilli osteoarticular infections: an easy method for clinical use.
Ribera A, et al. Infection 2018. PMID 29363049
Beta-lactams dose was calculated using a described formula (daily dose = 24 h × beta-lactam clearance × target "steady-state" concentration) to achieve concentrations above the MIC. ...The use of beta-lactams in CI was safe....
Beta-lactams dose was calculated using a described formula (daily dose = 24 h × beta-lactam clearance × target "steady-
Past and Present Perspectives on β-Lactamases
Bush K. Antimicrob Agents Chemother 2018 - Review. PMID 30061284 Free PMC article.
These well-studied enzymes, currently numbering almost 2,800 unique proteins, initially emerged from environmental sources, most likely to protect a producing bacterium from attack by naturally occurring β-lactams. ...
These well-studied enzymes, currently numbering almost 2,800 unique proteins, initially emerged from environmental sources, most likely to p …
Diagnosis and treatment of urinary tract infections across age groups
Chu CM and Lowder JL. Am J Obstet Gynecol 2018 - Review. PMID 29305250
Resistance is increasing to fluoroquinolones, beta-lactams, and trimethoprim-sulfamethoxazole. Most uropathogens still display good sensitivity to nitrofurantoin. ...In pregnancy, beta-lactams, nitrofurantoin, fosfomycin, and trimethoprim-sulfamethoxazole can be appropriate treatments. Interpreting the probability of urinary tract infection based on symptoms and testing allows for greater accuracy in diagnosis of urinary tract infection, decreasing overtreatment and encouraging antimicrobial stewardship....
Resistance is increasing to fluoroquinolones, beta-lactams, and trimethoprim-sulfamethoxazole. Most uropathogens still display …
Plasmid-mediated resistance is going wild
Dolejska M and Papagiannitsis CC. Plasmid 2018 - Review. PMID 30243983
The present review focuses on reports of plasmid-mediated resistance to critically important antimicrobial classes such as broad-spectrum beta-lactams and colistin in Enterobacteriaceae isolates from samples of wildlife origin. ...
The present review focuses on reports of plasmid-mediated resistance to critically important antimicrobial classes such as broad-spectrum …
Continuous Infusion Versus Intermittent Bolus of Beta-Lactams in Critically Ill Patients with Respiratory Infections: A Systematic Review and Meta-analysis.
Lee YR, et al. Eur J Drug Metab Pharmacokinet 2018 - Review. PMID 29027128
Beta-lactam antibiotics exhibit time-dependent pharmacodynamics; therefore, it is postulated that continuous infusion (CI) may optimize these parameters. ...CI of beta-lactam antibiotics in critically ill adult patients with respiratory infections significantly improved clinical cure rates when compared to IB (risk ratio [RR] 1.177; 95% CI 1.065-1.300). ...
Beta-lactam antibiotics exhibit time-dependent pharmacodynamics; therefore, it is postulated that continuous infusion (CI) may optimi
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