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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 3
1946 13
1947 5
1948 5
1949 3
1951 1
1952 14
1953 70
1954 130
1955 131
1956 143
1957 72
1958 1
1959 12
1960 19
1961 24
1962 32
1963 35
1964 24
1965 17
1966 15
1967 46
1968 43
1969 42
1970 41
1971 44
1972 51
1973 47
1974 130
1975 227
1976 146
1977 205
1978 166
1979 231
1980 167
1981 252
1982 347
1983 315
1984 417
1985 394
1986 314
1987 323
1988 265
1989 289
1990 252
1991 243
1992 226
1993 211
1994 271
1995 236
1996 200
1997 176
1998 212
1999 159
2000 184
2001 173
2002 198
2003 212
2004 229
2005 260
2006 246
2007 261
2008 263
2009 249
2010 278
2011 272
2012 335
2013 331
2014 366
2015 389
2016 406
2017 403
2018 300
2019 117
2020 3
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12,273 results
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Page 1
Beta-lactams as versatile synthetic intermediates for the preparation of heterocycles of biological interest.
Alcaide B and Almendros P. Curr Med Chem 2004 - Review. PMID 15279574
Thus, a handful of nonconventional fused polycyclic beta-lactams have been described in the literature in order to overcome the defence mechanisms of the bacteria. ...Additional impetus for research efforts on beta-lactam chemistry has been provided by the introduction of the beta-lactam synthon method, a term coined by Ojima 20 years ago, according to which 2-azetidinones can be employed as useful intermediates in organic synthesis. ...
Thus, a handful of nonconventional fused polycyclic beta-lactams have been described in the literature in order to overcome th …
Beta-lactams in the new millennium. Part-II: cephems, oxacephems, penams and sulbactam.
Singh GS. Mini Rev Med Chem 2004 - Review. PMID 14754446
Beta-lactam ring-containing compounds such as penicillins, ampicillin, amoxicillin, cephalosporins and carbapenems are among the most famous antibiotics. ...
Beta-lactam ring-containing compounds such as penicillins, ampicillin, amoxicillin, cephalosporins and carbapenems are among the most
Mass Spectral Profile for Rapid Differentiating Beta-Lactams from Their Ring-Opened Impurities.
Wang H, et al. Biomed Res Int 2015. PMID 26090434 Free PMC article.
In this job, characteristic profiles of the collision induced dissociation (CID) spectra of both β-lactams and ring-opened β-lactams were extracted from the MS data of six β-lactam antibiotics and their forty-five impurities, and were confirmed by the MS data reported in the literature. ...
In this job, characteristic profiles of the collision induced dissociation (CID) spectra of both β-lactams and ring-opened β-lacta
Recent advances in β-lactam synthesis
Hosseyni S and Jarrahpour A. Org Biomol Chem 2018 - Review. PMID 30209477
During the past century, β-lactams have been identified as the core of penicillin and since then several strategies have been developed for their synthesis. ...We approach the synthesis of β-lactams according to different retro synthesis strategies....
During the past century, β-lactams have been identified as the core of penicillin and since then several strategies have been develop …
Asymmetric synthesis of beta-lactams through the Staudinger reaction and their use as building blocks of natural and nonnatural products.
Palomo C, et al. Curr Med Chem 2004 - Review. PMID 15279571
In the last two decades, the better understanding of the mechanistic aspects of the beta-lactams' biological activity and their inhibition, and the chemical exploitation of beta-lactams as synthetic intermediates in organic chemistry, have experienced a continuous and somewhat complementary advance. ...This review accounts for the recent progress made in the asymmetric synthesis of beta-lactams (with special emphasis in the Staudinger reaction approach), as well as in their use as synthetic intermediates en route to natural products, including alpha- and beta-amino acids and peptides derived therefrom....
In the last two decades, the better understanding of the mechanistic aspects of the beta-lactams' biological activity and thei …
Cefpodoxime proxetil
Mostafa GAE, et al. Profiles Drug Subst Excip Relat Methodol 2019. PMID 31029216
Chirospecific synthesis of spirocyclic beta-lactams and their characterization as potent type II beta-turn inducing peptide mimetics.
Bittermann H and Gmeiner P. J Org Chem 2006. PMID 16388623
[reaction: see text] Starting from natural proline, a practical chirospecific synthesis of spirocyclic beta-lactams of type 2 is described when a methylene moiety showing minimal steric demand is employed as a constraint element for adjusting the dihedral angle psi(i + 1). ...NMR- and IR-based conformational studies clearly indicated that spiro-beta-lactams of type 2 can serve as efficient beta-turn nucleators....
[reaction: see text] Starting from natural proline, a practical chirospecific synthesis of spirocyclic beta-lactams of type 2 …
The aminolysis of N-aroyl beta-lactams occurs by a concerted mechanism.
Tsang WY, et al. Org Biomol Chem 2007. PMID 17252131
N-aroyl beta-lactams are imides with exo- and endocyclic acyl centres which react with amines in aqueous solution to give the ring opened beta-lactam aminolysis product. Unlike the strongly base catalysed aminolysis of beta-lactam antiobiotics, such as penicillins and cephaloridines, the rate law for the aminolysis of N-aroyl beta-lactams is dominated by a term with a first-order dependence on amine concentration in its free base form, indicative of an uncatalysed aminolysis reaction. ...
N-aroyl beta-lactams are imides with exo- and endocyclic acyl centres which react with amines in aqueous solution to give the …
Stereocontrolled synthesis of anticancer beta-lactams via the Staudinger reaction.
Banik BK, et al. Bioorg Med Chem 2005. PMID 15862989
Stereocontrolled synthesis of novel beta-lactams using polyaromatic imines following the Staudinger reaction has been accomplished. ...A donor-acceptor complex pathway is believed to be involved in the formation of cis-beta-lactams. The effect of a peri hydrogen has been found to be significant in controlling the stereochemistry of the resulting beta-lactams. ...
Stereocontrolled synthesis of novel beta-lactams using polyaromatic imines following the Staudinger reaction has been accompli …
Crystal structures of complexes between the R61 DD-peptidase and peptidoglycan-mimetic beta-lactams: a non-covalent complex with a "perfect penicillin".
Silvaggi NR, et al. J Mol Biol 2005. PMID 15581896
The bacterial D-alanyl-D-alanine transpeptidases (DD-peptidases) are the killing targets of beta-lactams, the most important clinical defense against bacterial infections. ...Finally, two covalent complexes with the traditional beta-lactams benzylpenicillin and cephalosporin C were determined for comparison with the peptidyl beta-lactams. ...
The bacterial D-alanyl-D-alanine transpeptidases (DD-peptidases) are the killing targets of beta-lactams, the most important c …
12,273 results
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