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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2003 2
2004 6
2005 2
2006 3
2007 6
2008 8
2009 5
2010 1
2011 4
2012 4
2013 5
2014 3
2015 5
2016 7
2017 10
2018 6
2019 12
2020 14
2021 8
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101 results
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Page 1
Normalization of CD4+ T cell metabolism reverses lupus.
Yin Y, Choi SC, Xu Z, Perry DJ, Seay H, Croker BP, Sobel ES, Brusko TM, Morel L. Yin Y, et al. Sci Transl Med. 2015 Feb 11;7(274):274ra18. doi: 10.1126/scitranslmed.aaa0835. Sci Transl Med. 2015. PMID: 25673763 Free PMC article.
Systemic lupus erythematosus (SLE) is an autoimmune disease in which autoreactive CD4(+) T cells play an essential role. CD4(+) T cells rely on glycolysis for inflammatory effector functions, but recent studies have shown that mitochondrial metabolism supports their …
Systemic lupus erythematosus (SLE) is an autoimmune disease in which autoreactive CD4(+) T cells play an essential role. CD4(+) T
T Cell Receptor Profiling in Type 1 Diabetes.
Jacobsen LM, Posgai A, Seay HR, Haller MJ, Brusko TM. Jacobsen LM, et al. Curr Diab Rep. 2017 Oct 11;17(11):118. doi: 10.1007/s11892-017-0946-4. Curr Diab Rep. 2017. PMID: 29022222 Free PMC article. Review.
PURPOSE OF REVIEW: The genetic susceptibility and dominant protection for type 1 diabetes (T1D) associated with human leukocyte antigen (HLA) haplotypes, along with minor risk variants, have long been thought to shape the T cell receptor (TCR) repertoire and eventual pheno …
PURPOSE OF REVIEW: The genetic susceptibility and dominant protection for type 1 diabetes (T1D) associated with human leukocyte antigen (HLA …
Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes.
Battaglia M, Ahmed S, Anderson MS, Atkinson MA, Becker D, Bingley PJ, Bosi E, Brusko TM, DiMeglio LA, Evans-Molina C, Gitelman SE, Greenbaum CJ, Gottlieb PA, Herold KC, Hessner MJ, Knip M, Jacobsen L, Krischer JP, Long SA, Lundgren M, McKinney EF, Morgan NG, Oram RA, Pastinen T, Peters MC, Petrelli A, Qian X, Redondo MJ, Roep BO, Schatz D, Skibinski D, Peakman M. Battaglia M, et al. Diabetes Care. 2020 Jan;43(1):5-12. doi: 10.2337/dc19-0880. Epub 2019 Nov 21. Diabetes Care. 2020. PMID: 31753960 Free PMC article.
Human Regulatory T Cells From Umbilical Cord Blood Display Increased Repertoire Diversity and Lineage Stability Relative to Adult Peripheral Blood.
Motwani K, Peters LD, Vliegen WH, El-Sayed AG, Seay HR, Lopez MC, Baker HV, Posgai AL, Brusko MA, Perry DJ, Bacher R, Larkin J, Haller MJ, Brusko TM. Motwani K, et al. Front Immunol. 2020 Apr 15;11:611. doi: 10.3389/fimmu.2020.00611. eCollection 2020. Front Immunol. 2020. PMID: 32351504 Free PMC article.
The human T lymphocyte compartment is highly dynamic over the course of a lifetime. ...These phenotypic changes, including the induction of T cell exhaustion and senescence, have the potential to negatively impact efficacy of adoptive T cell therapies (ACT). …
The human T lymphocyte compartment is highly dynamic over the course of a lifetime. ...These phenotypic changes, including the induct …
A Mutation in the Transcription Factor Foxp3 Drives T Helper 2 Effector Function in Regulatory T Cells.
Van Gool F, Nguyen MLT, Mumbach MR, Satpathy AT, Rosenthal WL, Giacometti S, Le DT, Liu W, Brusko TM, Anderson MS, Rudensky AY, Marson A, Chang HY, Bluestone JA. Van Gool F, et al. Immunity. 2019 Feb 19;50(2):362-377.e6. doi: 10.1016/j.immuni.2018.12.016. Epub 2019 Jan 29. Immunity. 2019. PMID: 30709738 Free PMC article.
Regulatory T (Treg) cells maintain immune tolerance through the master transcription factor forkhead box P3 (FOXP3), which is crucial for Treg cell function and homeostasis. ...Recapitulation of this Foxp3 variant in mice led to the development of an autoimmune syndrome co …
Regulatory T (Treg) cells maintain immune tolerance through the master transcription factor forkhead box P3 (FOXP3), which is crucial …
Low-Dose Anti-Thymocyte Globulin Preserves C-Peptide, Reduces HbA(1c), and Increases Regulatory to Conventional T-Cell Ratios in New-Onset Type 1 Diabetes: Two-Year Clinical Trial Data.
Haller MJ, Long SA, Blanchfield JL, Schatz DA, Skyler JS, Krischer JP, Bundy BN, Geyer SM, Warnock MV, Miller JL, Atkinson MA, Becker DJ, Baidal DA, DiMeglio LA, Gitelman SE, Goland R, Gottlieb PA, Herold KC, Marks JB, Moran A, Rodriguez H, Russell WE, Wilson DM, Greenbaum CJ; Type 1 Diabetes TrialNet ATG-GCSF Study Group. Haller MJ, et al. Diabetes. 2019 Jun;68(6):1267-1276. doi: 10.2337/db19-0057. Epub 2019 Apr 9. Diabetes. 2019. PMID: 30967424 Free PMC article. Clinical Trial.
Flow cytometry analyses demonstrated reduced circulating CD4:CD8 ratio, increased regulatory T-cell:conventional CD4 T-cell ratios, and increased PD-1(+)CD4(+) T cells following low-dose ATG and ATG/GCSF. ...
Flow cytometry analyses demonstrated reduced circulating CD4:CD8 ratio, increased regulatory T-cell:conventional CD4 T-cell ra …
Innate inflammation drives NK cell activation to impair Treg activity.
Dean JW, Peters LD, Fuhrman CA, Seay HR, Posgai AL, Stimpson SE, Brusko MA, Perry DJ, Yeh WI, Newby BN, Haller MJ, Muir AB, Atkinson MA, Mathews CE, Brusko TM. Dean JW, et al. J Autoimmun. 2020 Mar;108:102417. doi: 10.1016/j.jaut.2020.102417. Epub 2020 Feb 6. J Autoimmun. 2020. PMID: 32035746 Free PMC article.
IL-12 and IL-18 synergize to promote T(H)1 responses and have been implicated as accelerators of autoimmune pathogenesis in type 1 diabetes (T1D). We investigated the influence of these cytokines on immune cells involved in human T1D progression: natural killer (NK) cells, …
IL-12 and IL-18 synergize to promote T(H)1 responses and have been implicated as accelerators of autoimmune pathogenesis in type 1 di …
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