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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2003 2
2004 6
2005 2
2006 3
2007 6
2008 8
2009 5
2010 1
2011 4
2012 4
2013 5
2014 3
2015 5
2016 7
2017 12
2018 7
2019 14
2020 15
2021 23
2022 11
2023 4
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132 results
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Page 1
SARS-CoV-2 infection generates tissue-localized immunological memory in humans.
Poon MML, Rybkina K, Kato Y, Kubota M, Matsumoto R, Bloom NI, Zhang Z, Hastie KM, Grifoni A, Weiskopf D, Wells SB, Ural BB, Lam N, Szabo PA, Dogra P, Lee YS, Gray JI, Bradley MC, Brusko MA, Brusko TM, Saphire EO, Connors TJ, Sette A, Crotty S, Farber DL. Poon MML, et al. Sci Immunol. 2021 Nov 19;6(65):eabl9105. doi: 10.1126/sciimmunol.abl9105. Epub 2021 Nov 19. Sci Immunol. 2021. PMID: 34618554 Free PMC article.
Here, we report from examination of SARS-CoV-2 seropositive organ donors (ages 10 to 74) that CD4(+) T, CD8(+) T, and B cell memory generated in response to infection is present in the bone marrow, spleen, lung, and multiple lymph nodes (LNs) for up to 6 months afte …
Here, we report from examination of SARS-CoV-2 seropositive organ donors (ages 10 to 74) that CD4(+) T, CD8(+) T, and B cell m …
Normalization of CD4+ T cell metabolism reverses lupus.
Yin Y, Choi SC, Xu Z, Perry DJ, Seay H, Croker BP, Sobel ES, Brusko TM, Morel L. Yin Y, et al. Sci Transl Med. 2015 Feb 11;7(274):274ra18. doi: 10.1126/scitranslmed.aaa0835. Sci Transl Med. 2015. PMID: 25673763 Free PMC article.
Systemic lupus erythematosus (SLE) is an autoimmune disease in which autoreactive CD4(+) T cells play an essential role. CD4(+) T cells rely on glycolysis for inflammatory effector functions, but recent studies have shown that mitochondrial metabolism supports their …
Systemic lupus erythematosus (SLE) is an autoimmune disease in which autoreactive CD4(+) T cells play an essential role. CD4(+) T
A Novel Single Cell RNA-seq Analysis of Non-Myeloid Circulating Cells in Late Sepsis.
Darden DB, Dong X, Brusko MA, Kelly L, Fenner B, Rincon JC, Dirain ML, Ungaro R, Nacionales DC, Gauthier M, Kladde M, Brusko TM, Bihorac A, Moore FA, Loftus T, Bacher R, Moldawer LL, Mohr AM, Efron PA. Darden DB, et al. Front Immunol. 2021 Aug 16;12:696536. doi: 10.3389/fimmu.2021.696536. eCollection 2021. Front Immunol. 2021. PMID: 34484194 Free PMC article.
RESULTS: We identified unique transcriptomic patterns for multiple circulating immune cell subtypes, including B- and CD4(+), CD8(+), activated CD4(+) and activated CD8(+) T-lymphocytes, as well as natural killer (NK), NKT, and plasmacytoid dendritic cells in late sepsis p …
RESULTS: We identified unique transcriptomic patterns for multiple circulating immune cell subtypes, including B- and CD4(+), CD8(+), activa …
Single-Cell RNA-seq of Human Myeloid-Derived Suppressor Cells in Late Sepsis Reveals Multiple Subsets With Unique Transcriptional Responses: A Pilot Study.
Darden DB, Bacher R, Brusko MA, Knight P, Hawkins RB, Cox MC, Dirain ML, Ungaro R, Nacionales DC, Rincon JC, Gauthier ML, Kladde M, Bihorac A, Brusko TM, Moore FA, Brakenridge SC, Mohr AM, Moldawer LL, Efron PA. Darden DB, et al. Shock. 2021 May 1;55(5):587-595. doi: 10.1097/SHK.0000000000001671. Shock. 2021. PMID: 33021571 Free PMC article.
Editorial: Footprints of Immune Cells in the Type 1 Diabetic Pancreas.
Brusko TM, Mallone R, Rodriguez-Calvo T. Brusko TM, et al. Front Endocrinol (Lausanne). 2021 Oct 14;12:767012. doi: 10.3389/fendo.2021.767012. eCollection 2021. Front Endocrinol (Lausanne). 2021. PMID: 34721308 Free PMC article. No abstract available.
Time to Peak Glucose and Peak C-Peptide During the Progression to Type 1 Diabetes in the Diabetes Prevention Trial and TrialNet Cohorts.
Voss MG, Cuthbertson DD, Cleves MM, Xu P, Evans-Molina C, Palmer JP, Redondo MJ, Steck AK, Lundgren M, Larsson H, Moore WV, Atkinson MA, Sosenko JM, Ismail HM; DPT-1 and TrialNet Study Groups. Voss MG, et al. Diabetes Care. 2021 Oct;44(10):2329-2336. doi: 10.2337/dc21-0226. Epub 2021 Aug 6. Diabetes Care. 2021. PMID: 34362815 Free PMC article. Clinical Trial.
T Cell Receptor Profiling in Type 1 Diabetes.
Jacobsen LM, Posgai A, Seay HR, Haller MJ, Brusko TM. Jacobsen LM, et al. Curr Diab Rep. 2017 Oct 11;17(11):118. doi: 10.1007/s11892-017-0946-4. Curr Diab Rep. 2017. PMID: 29022222 Free PMC article. Review.
PURPOSE OF REVIEW: The genetic susceptibility and dominant protection for type 1 diabetes (T1D) associated with human leukocyte antigen (HLA) haplotypes, along with minor risk variants, have long been thought to shape the T cell receptor (TCR) repertoire and eventual pheno …
PURPOSE OF REVIEW: The genetic susceptibility and dominant protection for type 1 diabetes (T1D) associated with human leukocyte antigen (HLA …
Predictors of the Initiation of Islet Autoimmunity and Progression to Multiple Autoantibodies and Clinical Diabetes: The TEDDY Study.
Krischer JP, Liu X, Lernmark Å, Hagopian WA, Rewers MJ, She JX, Toppari J, Ziegler AG, Akolkar B; TEDDY Study Group. Krischer JP, et al. Diabetes Care. 2022 Oct 1;45(10):2271-2281. doi: 10.2337/dc21-2612. Diabetes Care. 2022. PMID: 36150053
Increased weight at 12 months and SNPs rs12708716_G (CLEC16A) and rs2292239_T (ERBB3) predicted GADA-first (autoantibody to GAD as the first appearing). For those having a father with type 1 diabetes, the SNPs rs2476601_A (PTPN22) and rs3184504_T (SH2B3) predicted b …
Increased weight at 12 months and SNPs rs12708716_G (CLEC16A) and rs2292239_T (ERBB3) predicted GADA-first (autoantibody to GAD as th …
132 results