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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2003 2
2004 6
2005 2
2006 3
2007 6
2008 8
2009 5
2010 1
2011 4
2012 4
2013 5
2014 3
2015 5
2016 7
2017 12
2018 6
2019 13
2020 15
2021 17
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111 results
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Page 1
Normalization of CD4+ T cell metabolism reverses lupus.
Yin Y, Choi SC, Xu Z, Perry DJ, Seay H, Croker BP, Sobel ES, Brusko TM, Morel L. Yin Y, et al. Sci Transl Med. 2015 Feb 11;7(274):274ra18. doi: 10.1126/scitranslmed.aaa0835. Sci Transl Med. 2015. PMID: 25673763 Free PMC article.
Systemic lupus erythematosus (SLE) is an autoimmune disease in which autoreactive CD4(+) T cells play an essential role. CD4(+) T cells rely on glycolysis for inflammatory effector functions, but recent studies have shown that mitochondrial metabolism supports their …
Systemic lupus erythematosus (SLE) is an autoimmune disease in which autoreactive CD4(+) T cells play an essential role. CD4(+) T
Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes.
Battaglia M, Ahmed S, Anderson MS, Atkinson MA, Becker D, Bingley PJ, Bosi E, Brusko TM, DiMeglio LA, Evans-Molina C, Gitelman SE, Greenbaum CJ, Gottlieb PA, Herold KC, Hessner MJ, Knip M, Jacobsen L, Krischer JP, Long SA, Lundgren M, McKinney EF, Morgan NG, Oram RA, Pastinen T, Peters MC, Petrelli A, Qian X, Redondo MJ, Roep BO, Schatz D, Skibinski D, Peakman M. Battaglia M, et al. Diabetes Care. 2020 Jan;43(1):5-12. doi: 10.2337/dc19-0880. Epub 2019 Nov 21. Diabetes Care. 2020. PMID: 31753960 Free PMC article.
A Mutation in the Transcription Factor Foxp3 Drives T Helper 2 Effector Function in Regulatory T Cells.
Van Gool F, Nguyen MLT, Mumbach MR, Satpathy AT, Rosenthal WL, Giacometti S, Le DT, Liu W, Brusko TM, Anderson MS, Rudensky AY, Marson A, Chang HY, Bluestone JA. Van Gool F, et al. Immunity. 2019 Feb 19;50(2):362-377.e6. doi: 10.1016/j.immuni.2018.12.016. Epub 2019 Jan 29. Immunity. 2019. PMID: 30709738 Free PMC article.
Regulatory T (Treg) cells maintain immune tolerance through the master transcription factor forkhead box P3 (FOXP3), which is crucial for Treg cell function and homeostasis. ...Recapitulation of this Foxp3 variant in mice led to the development of an autoimmune syndrome co …
Regulatory T (Treg) cells maintain immune tolerance through the master transcription factor forkhead box P3 (FOXP3), which is crucial …
Single-Cell RNA-seq of Human Myeloid-Derived Suppressor Cells in Late Sepsis Reveals Multiple Subsets With Unique Transcriptional Responses: A Pilot Study.
Darden DB, Bacher R, Brusko MA, Knight P, Hawkins RB, Cox MC, Dirain ML, Ungaro R, Nacionales DC, Rincon JC, Gauthier ML, Kladde M, Bihorac A, Brusko TM, Moore FA, Brakenridge SC, Mohr AM, Moldawer LL, Efron PA. Darden DB, et al. Shock. 2021 May 1;55(5):587-595. doi: 10.1097/SHK.0000000000001671. Shock. 2021. PMID: 33021571 Free PMC article.
T Cell Receptor Profiling in Type 1 Diabetes.
Jacobsen LM, Posgai A, Seay HR, Haller MJ, Brusko TM. Jacobsen LM, et al. Curr Diab Rep. 2017 Oct 11;17(11):118. doi: 10.1007/s11892-017-0946-4. Curr Diab Rep. 2017. PMID: 29022222 Free PMC article. Review.
PURPOSE OF REVIEW: The genetic susceptibility and dominant protection for type 1 diabetes (T1D) associated with human leukocyte antigen (HLA) haplotypes, along with minor risk variants, have long been thought to shape the T cell receptor (TCR) repertoire and eventual pheno …
PURPOSE OF REVIEW: The genetic susceptibility and dominant protection for type 1 diabetes (T1D) associated with human leukocyte antigen (HLA …
Immunophenotyping reveals distinct subgroups of lupus patients based on their activated T cell subsets.
Perry DJ, Titov AA, Sobel ES, Brusko TM, Morel L. Perry DJ, et al. Clin Immunol. 2020 Dec;221:108602. doi: 10.1016/j.clim.2020.108602. Epub 2020 Sep 29. Clin Immunol. 2020. PMID: 33007439
METHODS: Peripheral blood was analyzed using standardized flow cytometry panels. Transcriptional analysis of CD4(+) T cells was performed by microarrays and Nanostring assays. RESULTS: SLE CD4(+) T cells showed an increased expression of oxidative phosphorylation an …
METHODS: Peripheral blood was analyzed using standardized flow cytometry panels. Transcriptional analysis of CD4(+) T cells was perfo …
Characterization of Proinsulin T Cell Epitopes Restricted by Type 1 Diabetes-Associated HLA Class II Molecules.
Ihantola EL, Ilmonen H, Kailaanmäki A, Rytkönen-Nissinen M, Azam A, Maillère B, Lindestam Arlehamn CS, Sette A, Motwani K, Seay HR, Brusko TM, Knip M, Veijola R, Toppari J, Ilonen J, Kinnunen T. Ihantola EL, et al. J Immunol. 2020 May 1;204(9):2349-2359. doi: 10.4049/jimmunol.1901079. Epub 2020 Mar 30. J Immunol. 2020. PMID: 32229538 Free article.
Type 1 diabetes (T1D) is a T cell-mediated autoimmune disease in which the insulin-producing beta cells within the pancreas are destroyed. ...Several studies suggest that proinsulin is an early and integral target autoantigen in T1D. However, proinsulin epitopes recognized …
Type 1 diabetes (T1D) is a T cell-mediated autoimmune disease in which the insulin-producing beta cells within the pancreas are destr …
Immune Mechanisms and Pathways Targeted in Type 1 Diabetes.
Jacobsen LM, Newby BN, Perry DJ, Posgai AL, Haller MJ, Brusko TM. Jacobsen LM, et al. Curr Diab Rep. 2018 Aug 30;18(10):90. doi: 10.1007/s11892-018-1066-5. Curr Diab Rep. 2018. PMID: 30168021 Free PMC article. Review.
T cells display mitochondria hyperpolarization in human type 1 diabetes.
Chen J, Chernatynskaya AV, Li JW, Kimbrell MR, Cassidy RJ, Perry DJ, Muir AB, Atkinson MA, Brusko TM, Mathews CE. Chen J, et al. Sci Rep. 2017 Sep 7;7(1):10835. doi: 10.1038/s41598-017-11056-9. Sci Rep. 2017. PMID: 28883439 Free PMC article.
T lymphocytes constitute a major effector cell population in autoimmune type 1 diabetes. Despite essential functions of mitochondria in regulating activation, proliferation, and apoptosis of T cells, little is known regarding T cell metabolism in the progress
T lymphocytes constitute a major effector cell population in autoimmune type 1 diabetes. Despite essential functions of mitochondria
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