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Quoted phrase not found in phrase index: "butandial"
Page 1
The photohydrolysis of furans.
Frank N, Chaudhari MB, Leutzsch M, Helmich-Paris B, Bruzzese PC, Nater D, Nöthling N, Schnegg A, Waldvogel SR, List B. Frank N, et al. Science. 2026 Jan 15;391(6782):267-274. doi: 10.1126/science.aec6532. Epub 2026 Jan 15. Science. 2026. PMID: 41538456
By contrast, the conceptually straightforward redox-neutral hydrolysis of furan to succinaldehyde and 2-substituted furans to 1,4-ketoaldehydes has been considered unfeasible owing to their endergonicity and polymerization side reactivity. In this work, we report the reali …
By contrast, the conceptually straightforward redox-neutral hydrolysis of furan to succinaldehyde and 2-substituted furans to 1,4-ket …
Prostaglandin Total Synthesis Enabled by the Organocatalytic Dimerization of Succinaldehyde.
Bennett SH, Coulthard G, Aggarwal VK. Bennett SH, et al. Chem Rec. 2020 Sep;20(9):936-947. doi: 10.1002/tcr.202000054. Epub 2020 Jul 16. Chem Rec. 2020. PMID: 32672398 Review.
In this personal account, we describe our own approach to the family of prostaglandins, which centers around the synthesis of a key enal intermediate, formed from the l-proline catalysed dimerization of succinaldehyde. We highlight the discovery and further optimization of …
In this personal account, we describe our own approach to the family of prostaglandins, which centers around the synthesis of a key enal int …
Glycerolphosphorylethanolamine and Several Other Biochemical Amines Are Targets of Furan's Reactive Metabolite in Rodents.
Vevang KR, Trinh A, Raj M, Ocasio-Ramirez C, Zhao Y, von Weymarn LB, Peterson LA. Vevang KR, et al. Chem Res Toxicol. 2026 May 18;39(5):939-947. doi: 10.1021/acs.chemrestox.6c00053. Epub 2026 May 4. Chem Res Toxicol. 2026. PMID: 42083458 Free PMC article.
Chemical characterization of hepatocellular and urinary metabolites indicates that the reaction of BDA with glutathione (GSH) generates a reactive GSH conjugate, 2-(S-glutathionyl)succinaldehyde (GSH-BDA), that targets protein lysine residues and polyamines to form GSH-BDA …
Chemical characterization of hepatocellular and urinary metabolites indicates that the reaction of BDA with glutathione (GSH) generates a re …
Metabolic Engineering of Escherichia coli for the Improved Malonic Acid Production.
Liu H, Tian M, Dong P, Zhao Y, Deng Y. Liu H, et al. ACS Synth Biol. 2025 Apr 18;14(4):1277-1287. doi: 10.1021/acssynbio.5c00005. Epub 2025 Apr 7. ACS Synth Biol. 2025. PMID: 40195009
Among these, the fumaric acid pathway comprising four key enzymes including the aspartase (AspA), the decarboxylase (PanD), the beta-alanine-pyruvate transaminase (Pa0132), and the succinic aldehyde dehydrogenase (YneI) was identified as the most effective for MA pr …
Among these, the fumaric acid pathway comprising four key enzymes including the aspartase (AspA), the decarboxylase (PanD), the beta-alanine …
Comparison of the mycobactericidal activity of ortho- phthalaldehyde, glutaraldehyde and other dialdehydes by a quantitative suspension test.
Fraud S, Maillard JY, Russell AD. Fraud S, et al. J Hosp Infect. 2001 Jul;48(3):214-21. doi: 10.1053/jhin.2001.1009. J Hosp Infect. 2001. PMID: 11439009
The aldehydes tested were a new high-level disinfectant, ortho-phthalaldehyde (OPA) at 0.5% (v/v) unadjusted pH 6.5 and pH 8, GTA at 0.5% (v/v) pH 8, glyoxal at 0.5% (v/v) pH 8 and 10% (v/v) unadjusted pH 2.8, malonaldehyde sodium salt (NaMDA) at 0.5% (w/v) pH 8 and 10% (w/v) una …
The aldehydes tested were a new high-level disinfectant, ortho-phthalaldehyde (OPA) at 0.5% (v/v) unadjusted pH 6.5 and pH 8, GTA at 0.5% (v …
2-Hydroxy-succinaldehyde, a lipid peroxidation product proving that polyunsaturated fatty acids are able to react with three molecules of oxygen.
Mlakar A, Spiteller G. Mlakar A, et al. Free Radic Res. 1997 Jan;26(1):57-62. doi: 10.3109/10715769709097784. Free Radic Res. 1997. PMID: 9018472
2-Hydroxy-succinaldehyde was detected by a GC/MS analysis of trapped aldehydic compounds obtained after Fe2+/ascorbate lipid peroxidation of arachidonic acid. ...
2-Hydroxy-succinaldehyde was detected by a GC/MS analysis of trapped aldehydic compounds obtained after Fe2+/ascorbate lipid peroxida …
Total Synthesis of Thromboxane B2 via a Key Bicyclic Enal Intermediate.
Jing C, Aggarwal VK. Jing C, et al. Org Lett. 2020 Aug 21;22(16):6505-6509. doi: 10.1021/acs.orglett.0c02299. Epub 2020 Aug 7. Org Lett. 2020. PMID: 32806168
The synthesis employs our organocatalytic aldol reaction of succinaldehyde to give a key bicyclic enal intermediate. From here, the synthetic strategy involves a conjugate addition of an alkenyl side chain to the bicyclic enal, Baeyer-Villiger oxidation, and a highly Z-sel …
The synthesis employs our organocatalytic aldol reaction of succinaldehyde to give a key bicyclic enal intermediate. From here, the s …
Catalyst-free direct regiospecific multicomponent synthesis of C3-functionalized pyrroles.
Pawar AP, Yadav J, Dolas AJ, Iype E, Rangan K, Kumar I. Pawar AP, et al. Org Biomol Chem. 2022 Jul 27;20(29):5747-5758. doi: 10.1039/d2ob00961g. Org Biomol Chem. 2022. PMID: 35775588
The enamine intermediate, in situ generated from succinaldehyde and a primary amine, was trapped with activated carbonyls before the Paal-Knorr reaction in a direct multicomponent "just-mix" fashion to furnish pyrroles with overall good yields. ...
The enamine intermediate, in situ generated from succinaldehyde and a primary amine, was trapped with activated carbonyls before the …
Two-pot synthesis and photophysical studies of 1,6-disubstituted 5-aza-indoles from succinaldehyde and N-aryl propargylic-imines.
Vanaparthi S, Mamta, Yadav J, Pawar AP, Iype E, Rana S, Kumar I. Vanaparthi S, et al. Org Biomol Chem. 2021 Dec 15;19(48):10601-10610. doi: 10.1039/d1ob01949j. Org Biomol Chem. 2021. PMID: 34859806
A two-pot synthesis of 5-aza-indoles has been developed from aqueous succinaldehyde and N-aryl propargylic-imines. This overall protocol involves: (i) the metal-free [3 + 2] annulation of aqueous succinaldehyde and N-aryl propargylic-imines to access 2-alkynyl-pyrro …
A two-pot synthesis of 5-aza-indoles has been developed from aqueous succinaldehyde and N-aryl propargylic-imines. This overall proto …
Enantioselective Total Synthesis of Beraprost Using Organocatalyst.
Umemiya S, Sakamoto D, Kawauchi G, Hayashi Y. Umemiya S, et al. Org Lett. 2017 Mar 3;19(5):1112-1115. doi: 10.1021/acs.orglett.7b00134. Epub 2017 Feb 23. Org Lett. 2017. PMID: 28231006
A unique tricyclic core in beraprost was synthesized efficiently by utilizing the asymmetric organocatalyst-mediated formal [3 + 2] cycloaddition reaction of succinaldehyde with nitroalkene as a key step. The synthesis of the optically active Horner-Wadsworth-Emmons reagen …
A unique tricyclic core in beraprost was synthesized efficiently by utilizing the asymmetric organocatalyst-mediated formal [3 + 2] cycloadd …
37 results