Novel butanehydrazide derivatives of purine-2,6-dione as dual PDE4/7 inhibitors with potential anti-inflammatory activity: Design, synthesis and biological evaluation.
Chłoń-Rzepa G, Jankowska A, Ślusarczyk M, Świerczek A, Pociecha K, Wyska E, Bucki A, Gawalska A, Kołaczkowski M, Pawłowski M.
Chłoń-Rzepa G, et al.
Eur J Med Chem. 2018 Feb 25;146:381-394. doi: 10.1016/j.ejmech.2018.01.068. Epub 2018 Feb 4.
Eur J Med Chem. 2018.
PMID: 29407965
A novel butanehydrazide derivatives of purine-2,6-dione designed using a ligand-based approach were synthesized and their in vitro activity against both PDE4B and PDE7A isoenzymes was assessed. ...Moreover, docking studies explained the importance of N-(2,3,4-trihydroxyben …
A novel butanehydrazide derivatives of purine-2,6-dione designed using a ligand-based approach were synthesized and their in vitro ac …