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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1851 1
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1861 1
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1885 2
1886 1
1888 1
1890 1
1891 1
1894 2
1895 1
1907 1
1910 2
1911 1
1912 2
1917 1
1918 1
1923 1
1925 1
1926 1
1928 1
1930 1
1939 1
1941 1
1943 1
1944 1
1945 13
1946 20
1947 13
1948 13
1949 17
1950 20
1951 35
1952 39
1953 66
1954 64
1955 45
1956 52
1957 57
1958 38
1959 48
1960 41
1961 41
1962 74
1963 123
1964 177
1965 125
1966 122
1967 169
1968 211
1969 238
1970 279
1971 269
1972 301
1973 310
1974 329
1975 339
1976 341
1977 291
1978 295
1979 310
1980 321
1981 335
1982 369
1983 391
1984 486
1985 493
1986 526
1987 498
1988 519
1989 614
1990 619
1991 643
1992 640
1993 607
1994 680
1995 661
1996 678
1997 674
1998 652
1999 705
2000 758
2001 748
2002 754
2003 733
2004 779
2005 819
2006 901
2007 869
2008 876
2009 863
2010 962
2011 988
2012 1070
2013 1129
2014 1200
2015 1206
2016 1263
2017 1249
2018 1382
2019 1371
2020 1421
2021 1497
2022 1500
2023 1455
2024 1543
2025 1620
2026 773

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42,106 results

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Page 1
Caffeine: cognitive and physical performance enhancer or psychoactive drug?
Cappelletti S, Piacentino D, Sani G, Aromatario M. Cappelletti S, et al. Curr Neuropharmacol. 2015 Jan;13(1):71-88. doi: 10.2174/1570159X13666141210215655. Curr Neuropharmacol. 2015. PMID: 26074744 Free PMC article. Review.
Caffeine use is increasing worldwide. The underlying motivations are mainly concentration and memory enhancement and physical performance improvement. ...Thus, it is of interest to examine whether these effects could be detrimental for health. Furthermore, caffeine …
Caffeine use is increasing worldwide. The underlying motivations are mainly concentration and memory enhancement and physical perform …
Common questions and misconceptions about caffeine supplementation: what does the scientific evidence really show?
Antonio J, Newmire DE, Stout JR, Antonio B, Gibbons M, Lowery LM, Harper J, Willoughby D, Evans C, Anderson D, Goldstein E, Rojas J, Monsalves-Álvarez M, Forbes SC, Gomez Lopez J, Ziegenfuss T, Moulding BD, Candow D, Sagner M, Arent SM. Antonio J, et al. J Int Soc Sports Nutr. 2024 Dec;21(1):2323919. doi: 10.1080/15502783.2024.2323919. Epub 2024 Mar 11. J Int Soc Sports Nutr. 2024. PMID: 38466174 Free PMC article. Review.
7. Can too much caffeine kill you? 8. Are there sex differences regarding caffeine's effects? 9. Does caffeine work for everyone? 10. Does caffeine cause heart problems? 11. Does caffeine promote the loss of bone mineral? 12. Should pregnant wom …
7. Can too much caffeine kill you? 8. Are there sex differences regarding caffeine's effects? 9. Does caffeine work for …
Caffeine and exercise: metabolism, endurance and performance.
Graham TE. Graham TE. Sports Med. 2001;31(11):785-807. doi: 10.2165/00007256-200131110-00002. Sports Med. 2001. PMID: 11583104 Review.
It appears that male and female athletes have similar caffeine pharmacokinetics, i.e., for a given dose of caffeine, the time course and absolute plasma concentrations of caffeine and its metabolites are the same. In addition, exercise or dehydration does not …
It appears that male and female athletes have similar caffeine pharmacokinetics, i.e., for a given dose of caffeine, the time …
Coffee and mental disorders: How caffeine affects anxiety and depression.
Meamar M, Raise-Abdullahi P, Rashidy-Pour A, Raeis-Abdollahi E. Meamar M, et al. Prog Brain Res. 2024;288:115-132. doi: 10.1016/bs.pbr.2024.06.015. Epub 2024 Jul 8. Prog Brain Res. 2024. PMID: 39168554 Review.
Individual variations in caffeine metabolism, sensitivity, and genetic factors considerably impact responses to caffeine. The chapter also explores the therapeutic potential of caffeine as an adjunct treatment and outlines challenges and future research direc …
Individual variations in caffeine metabolism, sensitivity, and genetic factors considerably impact responses to caffeine. The …
Interindividual Differences in Caffeine Metabolism and Factors Driving Caffeine Consumption.
Nehlig A. Nehlig A. Pharmacol Rev. 2018 Apr;70(2):384-411. doi: 10.1124/pr.117.014407. Epub 2018 Mar 7. Pharmacol Rev. 2018. PMID: 29514871 Review.
Caffeine also interacts with many medications. All these factors will be reviewed in the present document and discussed in light of the most recent data concerning the genetic variability affecting caffeine levels and effects at the pharmacokinetic and pharmacodynam …
Caffeine also interacts with many medications. All these factors will be reviewed in the present document and discussed in light of t …
Is caffeine a cognitive enhancer?
Nehlig A. Nehlig A. J Alzheimers Dis. 2010;20 Suppl 1:S85-94. doi: 10.3233/JAD-2010-091315. J Alzheimers Dis. 2010. PMID: 20182035 Free article. Review.
Caffeine does not usually affect performance in learning and memory tasks, although caffeine may occasionally have facilitatory or inhibitory effects on memory and learning. Caffeine facilitates learning in tasks in which information is presented passively; i …
Caffeine does not usually affect performance in learning and memory tasks, although caffeine may occasionally have facilitator …
Effects of caffeine on human behavior.
Smith A. Smith A. Food Chem Toxicol. 2002 Sep;40(9):1243-55. doi: 10.1016/s0278-6915(02)00096-0. Food Chem Toxicol. 2002. PMID: 12204388 Review.
The literature suggests that the following effects on behavior of adult humans may occur when individuals consume moderate amounts of caffeine. (1) Caffeine increases alertness and reduces fatigue. This may be especially important in low arousal situations (e.g. wor …
The literature suggests that the following effects on behavior of adult humans may occur when individuals consume moderate amounts of caf …
Effects of caffeine on sleep quality and daytime functioning.
O'Callaghan F, Muurlink O, Reid N. O'Callaghan F, et al. Risk Manag Healthc Policy. 2018 Dec 7;11:263-271. doi: 10.2147/RMHP.S156404. eCollection 2018. Risk Manag Healthc Policy. 2018. PMID: 30573997 Free PMC article. Review.
Caffeine (particularly in the form of coffee) is one of the most widely consumed stimulants in the world, with 90% of American adults consuming caffeine-infused beverages almost daily. ...Scholars for some time have considered that the supposed psychoactive benefits …
Caffeine (particularly in the form of coffee) is one of the most widely consumed stimulants in the world, with 90% of American adults …
Genetic susceptibility to caffeine intake and metabolism: a systematic review.
Low JJ, Tan BJ, Yi LX, Zhou ZD, Tan EK. Low JJ, et al. J Transl Med. 2024 Oct 22;22(1):961. doi: 10.1186/s12967-024-05737-z. J Transl Med. 2024. PMID: 39438936 Free PMC article.
BACKGROUND: Coffee and tea consumption account for most caffeine intake and 2-3 billion cups are taken daily around the world. Caffeine dependence is a widespread but under recognized problem. OBJECTIVES: To conduct a systematic review on the genetic susceptibility …
BACKGROUND: Coffee and tea consumption account for most caffeine intake and 2-3 billion cups are taken daily around the world. Caf …
Effects of Caffeine on Resistance Exercise: A Review of Recent Research.
Grgic J. Grgic J. Sports Med. 2021 Nov;51(11):2281-2298. doi: 10.1007/s40279-021-01521-x. Epub 2021 Jul 22. Sports Med. 2021. PMID: 34291426 Review.
Habitual caffeine intake and polymorphisms within CYP1A2 and ADORA2A do not seem to modulate caffeine's ergogenic effects on resistance exercise. Consuming lower doses of caffeine (e.g., 2-3 mg/kg) appears to be comparably ergogenic to consuming high doses of …
Habitual caffeine intake and polymorphisms within CYP1A2 and ADORA2A do not seem to modulate caffeine's ergogenic effects on r …
42,106 results
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