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Mannheimia haemolytica leukotoxin-induced cytolysis of caprine (Capra hircus) leukocytes is mediated by the CD18 subunit of beta2-integrins.
Fett T, Zecchinon L, Vanden Bergh P, Desmecht D. Fett T, et al. Microb Pathog. 2008 Nov-Dec;45(5-6):337-42. doi: 10.1016/j.micpath.2008.08.001. Epub 2008 Aug 14. Microb Pathog. 2008. PMID: 18775487
Mannheimiosis is the major respiratory disease among some ruminants, whereas it is not pathogenic for other mammals, an observation that has been attributed to a specific interaction between Mannheimia haemolytica leukotoxin (Lkt) and bovine or ovine CD18 subunit of …
Mannheimiosis is the major respiratory disease among some ruminants, whereas it is not pathogenic for other mammals, an observation that has …
Characterization of the caprine (Capra hircus) beta-2 integrin CD18-encoding cDNA and identification of mutations potentially responsible for the ruminant-specific virulence of Mannheimia haemolytica.
Zecchinon L, Fett T, Baise E, Desmecht D. Zecchinon L, et al. Mol Membr Biol. 2004 Sep-Oct;21(5):289-95. doi: 10.1080/09687680412331282785. Mol Membr Biol. 2004. PMID: 15513736
Moreover, comparisons of ruminant versus non-ruminant CD18 sequences allowed the identification of 16 potential mutation sites that could be held responsible for the unique virulence of Mannheimia haemolytica for ruminants. Mannheimiosis is known to be the major res …
Moreover, comparisons of ruminant versus non-ruminant CD18 sequences allowed the identification of 16 potential mutation sites that could be …
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