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Page 1
Metabolic features of the cell danger response.
Naviaux RK. Naviaux RK. Mitochondrion. 2014 May;16:7-17. doi: 10.1016/j.mito.2013.08.006. Epub 2013 Aug 24. Mitochondrion. 2014. PMID: 23981537 Free article. Review.
The cell danger response (CDR) is the evolutionarily conserved metabolic response that protects cells and hosts from harm. ...
The cell danger response (CDR) is the evolutionarily conserved metabolic response that protects cells and hosts from ha …
Perspective: Cell danger response Biology-The new science that connects environmental health with mitochondria and the rising tide of chronic illness.
Naviaux RK. Naviaux RK. Mitochondrion. 2020 Mar;51:40-45. doi: 10.1016/j.mito.2019.12.005. Epub 2019 Dec 23. Mitochondrion. 2020. PMID: 31877376 Free article. Review.
This paper is written for non-specialists in mitochondrial biology to provide access to an important area of science that has broad implications for all people. The cell danger response (CDR) is a universal response to environmental threat or injury. ...
This paper is written for non-specialists in mitochondrial biology to provide access to an important area of science that has broad implicat …
Incomplete Healing as a Cause of Aging: The Role of Mitochondria and the Cell Danger Response.
Naviaux RK. Naviaux RK. Biology (Basel). 2019 May 11;8(2):27. doi: 10.3390/biology8020027. Biology (Basel). 2019. PMID: 31083530 Free PMC article. Review.
Developmentally delayed and arrested cells accumulate in the three stages of the cell danger response (CDR1, 2, and 3) that make up the healing cycle. Cells stuck in the CDR create physical and metabolic separation-buffer zones of reduced communication-betwee …
Developmentally delayed and arrested cells accumulate in the three stages of the cell danger response (CDR1, 2, and 3) …
Mitochondrial and metabolic features of salugenesis and the healing cycle.
Naviaux RK. Naviaux RK. Mitochondrion. 2023 May;70:131-163. doi: 10.1016/j.mito.2023.04.003. Epub 2023 Apr 27. Mitochondrion. 2023. PMID: 37120082 Free article. Review.
Energy and metabolic resources are provided by mitochondrial and metabolic transformations that drive the cell danger response (CDR) and create the three phases of the healing cycle: Phase 1-Inflammation, Phase 2-Proliferation, and Phase 3-Differentiation. .. …
Energy and metabolic resources are provided by mitochondrial and metabolic transformations that drive the cell danger respo …
Antipurinergic therapy for autism-An in-depth review.
Naviaux RK. Naviaux RK. Mitochondrion. 2018 Nov;43:1-15. doi: 10.1016/j.mito.2017.12.007. Epub 2017 Dec 16. Mitochondrion. 2018. PMID: 29253638 Free article. Review.
Based on a new unifying theory of pathogenesis for autism called the cell danger response (CDR) hypothesis, this study of 10 boys, ages 5-14years, showed that all 5 boys who received antipurinergic therapy (APT) with a single intravenous dose of suramin exper …
Based on a new unifying theory of pathogenesis for autism called the cell danger response (CDR) hypothesis, this study …
Cerebrospinal fluid and plasma metabolomics of acute endurance exercise.
Li K, Schön M, Naviaux JC, Monk JM, Alchus-Laiferová N, Wang L, Straka I, Matejička P, Valkovič P, Ukropec J, Tarnopolsky MA, Naviaux RK, Ukropcová B. Li K, et al. FASEB J. 2022 Jul;36(7):e22408. doi: 10.1096/fj.202200509R. FASEB J. 2022. PMID: 35713567
Metabolic features of chronic fatigue syndrome.
Naviaux RK, Naviaux JC, Li K, Bright AT, Alaynick WA, Wang L, Baxter A, Nathan N, Anderson W, Gordon E. Naviaux RK, et al. Proc Natl Acad Sci U S A. 2016 Sep 13;113(37):E5472-80. doi: 10.1073/pnas.1607571113. Epub 2016 Aug 29. Proc Natl Acad Sci U S A. 2016. PMID: 27573827 Free PMC article.
Metabolic features and regulation of the healing cycle-A new model for chronic disease pathogenesis and treatment.
Naviaux RK. Naviaux RK. Mitochondrion. 2019 May;46:278-297. doi: 10.1016/j.mito.2018.08.001. Epub 2018 Aug 9. Mitochondrion. 2019. PMID: 30099222 Free article.
This study defines the healing cycle in metabolic terms and reframes the pathophysiology of chronic illness as the result of metabolic signaling abnormalities that block healing and cause the normal stages of the cell danger response (CDR) to persist abnormal …
This study defines the healing cycle in metabolic terms and reframes the pathophysiology of chronic illness as the result of metabolic signa …
Antipurinergic therapy corrects the autism-like features in the Fragile X (Fmr1 knockout) mouse model.
Naviaux JC, Wang L, Li K, Bright AT, Alaynick WA, Williams KR, Powell SB, Naviaux RK. Naviaux JC, et al. Mol Autism. 2015 Jan 13;6:1. doi: 10.1186/2040-2392-6-1. eCollection 2015. Mol Autism. 2015. PMID: 25705365 Free PMC article.
These metabolic pathways were previously identified as functionally related mediators of the evolutionarily conserved cell danger response (CDR). CONCLUSIONS: The data show that antipurinergic therapy improves the multisystem, ASD-like features of both the en …
These metabolic pathways were previously identified as functionally related mediators of the evolutionarily conserved cell danger …
Urinary metabolomics of young Italian autistic children supports abnormal tryptophan and purine metabolism.
Gevi F, Zolla L, Gabriele S, Persico AM. Gevi F, et al. Mol Autism. 2016 Nov 24;7:47. doi: 10.1186/s13229-016-0109-5. eCollection 2016. Mol Autism. 2016. PMID: 27904735 Free PMC article.
These results are consistent with the proposal of a purine-driven cell danger response, accompanied by overproduction of epileptogenic and excitotoxic quinolinic acid, large reductions in melatonin synthesis, and gut dysbiosis. ...
These results are consistent with the proposal of a purine-driven cell danger response, accompanied by overproduction o …
Human Herpesvirus-6 Reactivation, Mitochondrial Fragmentation, and the Coordination of Antiviral and Metabolic Phenotypes in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.
Schreiner P, Harrer T, Scheibenbogen C, Lamer S, Schlosser A, Naviaux RK, Prusty BK. Schreiner P, et al. Immunohorizons. 2020 Apr 23;4(4):201-215. doi: 10.4049/immunohorizons.2000006. Immunohorizons. 2020. PMID: 32327453 Free article.
In conclusion, HHV-6 reactivation in ME/CFS patients activates a multisystem, proinflammatory, cell danger response that protects against certain RNA and DNA virus infections but comes at the cost of mitochondrial fragmentation and severely compromised energy …
In conclusion, HHV-6 reactivation in ME/CFS patients activates a multisystem, proinflammatory, cell danger response tha …