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16 results

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4-Chlorothymol Exerts Antiplasmodial Activity Impeding Redox Defense System in Plasmodium falciparum.
Kumar S, Mina PR, Kumar R, Pal A, Ahmad A, Tandon S, Darokar MP. Kumar S, et al. Front Pharmacol. 2021 Mar 10;12:628970. doi: 10.3389/fphar.2021.628970. eCollection 2021. Front Pharmacol. 2021. PMID: 33776772 Free PMC article.
Among the thymol derivatives tested, 4-chlorothymol showed potential activity against sensitive and resistant strains of P. falciparum. 4-Chlorothymol was found to increase the reactive oxygen species and reactive nitrogen species level. Furthermore, 4-chlorothym …
Among the thymol derivatives tested, 4-chlorothymol showed potential activity against sensitive and resistant strains of P. falciparu …
A multiorganism pipeline for antiseizure drug discovery: Identification of chlorothymol as a novel gamma-aminobutyric acidergic anticonvulsant.
Jones A, Barker-Haliski M, Ilie AS, Herd MB, Baxendale S, Holdsworth CJ, Ashton JP, Placzek M, Jayasekera BAP, Cowie CJA, Lambert JJ, Trevelyan AJ, White HS, Marson AG, Cunliffe VT, Sills GJ, Morgan A. Jones A, et al. Epilepsia. 2020 Oct;61(10):2106-2118. doi: 10.1111/epi.16644. Epub 2020 Aug 14. Epilepsia. 2020. PMID: 32797628 Free PMC article.
A subsequent genetic screen in C elegans revealed the molecular target of chlorothymol to be LGC-37, a worm gamma-aminobutyric acid type A (GABA(A) ) receptor subunit. ...Finally, chlorothymol exhibited in vivo anticonvulsant efficacy in several mouse seizure assays …
A subsequent genetic screen in C elegans revealed the molecular target of chlorothymol to be LGC-37, a worm gamma-aminobutyric acid t …
Ointment bases for chlorothymol.
BELEN TA, REDDISH GF, HUYCK CL. BELEN TA, et al. Am J Pharm Sci Support Public Health. 1962 Jul;134:245-53. Am J Pharm Sci Support Public Health. 1962. PMID: 13866714 No abstract available.
4-Chloro-2-Isopropyl-5-Methylphenol Exhibits Antimicrobial and Adjuvant Activity against Methicillin-Resistant Staphylococcus aureus.
Kim BC, Kim H, Lee HS, Kim SH, Cho DH, Jung HJ, Bhatia SK, Yune PS, Joo HS, Kim JS, Kim W, Yang YH. Kim BC, et al. J Microbiol Biotechnol. 2022 Jun 28;32(6):730-739. doi: 10.4014/jmb.2203.03054. Epub 2022 May 6. J Microbiol Biotechnol. 2022. PMID: 35586930 Free PMC article.
Here, we assessed the antimicrobial activity of several thymol derivatives and found that 4-chloro-2-isopropyl-5-methylphenol (chlorothymol) has antimicrobial activity against MRSA and in addition it also prevents biofilm formation. Chlorothymol inhibited staphyloxa …
Here, we assessed the antimicrobial activity of several thymol derivatives and found that 4-chloro-2-isopropyl-5-methylphenol (chlorothym …
Synthesis of 1,2,3-triazole-thymol derivatives as potential antimicrobial agents.
Addo JK, Owusu-Ansah E, Dayie NTKD, Cheseto X, Torto B. Addo JK, et al. Heliyon. 2022 Oct 1;8(10):e10836. doi: 10.1016/j.heliyon.2022.e10836. eCollection 2022 Oct. Heliyon. 2022. PMID: 36217474 Free PMC article.
MATERIALS AND METHODS: A series of ten 1,2,3-triazole-thymol derivatives 1-10 were synthesized from thymol, by a click reaction between O-propargyl terminal alkyne of thymol and its chlorothymol with benzyl azide and substituted benzyl azides. Their structures were confirm …
MATERIALS AND METHODS: A series of ten 1,2,3-triazole-thymol derivatives 1-10 were synthesized from thymol, by a click reaction between O-pr …
Neuroprotective effects of gabaergic phenols correlated with their pharmacological and antioxidant properties.
Delgado-Marín L, Sánchez-Borzone M, García DA. Delgado-Marín L, et al. Life Sci. 2017 Apr 15;175:11-15. doi: 10.1016/j.lfs.2017.03.005. Epub 2017 Mar 10. Life Sci. 2017. PMID: 28288780
These phenols include the naturally occurring compounds thymol, carvacrol and eugenol, the synthetic product chlorothymol, and the most widely used intravenous anesthetic, propofol, as a reference compound. ...SIGNIFICANCE: Testing the intracellular oxidation levels sugges …
These phenols include the naturally occurring compounds thymol, carvacrol and eugenol, the synthetic product chlorothymol, and the mo …
GABAergic pharmacological activity of propofol related compounds as possible enhancers of general anesthetics and interaction with membranes.
Reiner GN, Delgado-Marín L, Olguín N, Sánchez-Redondo S, Sánchez-Borzone M, Rodríguez-Farré E, Suñol C, García DA. Reiner GN, et al. Cell Biochem Biophys. 2013 Nov;67(2):515-25. doi: 10.1007/s12013-013-9537-4. Cell Biochem Biophys. 2013. PMID: 23456454 Free article.
These results strongly suggest that the phenols studied are positive allosteric modulators of this receptor. Chlorothymol showed a bell-type effect, reducing its positive effect at concentrations >100 muM. ...Although all compounds were able to decrease the micro viscos …
These results strongly suggest that the phenols studied are positive allosteric modulators of this receptor. Chlorothymol showed a be …
SPME-GC-MS combined with chemometrics to assess the impact of fermentation time on the components, flavor, and function of Laoxianghuang.
Yaqun L, Hanxu L, Wanling L, Yingzhu X, Mouquan L, Yuzhong Z, Lei H, Yingkai Y, Yidong C. Yaqun L, et al. Front Nutr. 2022 Aug 2;9:915776. doi: 10.3389/fnut.2022.915776. eCollection 2022. Front Nutr. 2022. PMID: 35983487 Free PMC article.
Terpenes (mainly limonene, gamma-terpinene and cymene) displayed the highest relative content and were positively correlated with the year of fermentation, followed by alcohols (mainly alpha-terpineol, beta-terpinenol, and gamma-terpineol), ketones (mainly cyclohexanone, D(+)-car …
Terpenes (mainly limonene, gamma-terpinene and cymene) displayed the highest relative content and were positively correlated with the year o …
16 results