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431 results

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Page 1
Chlorpyrifos and Chlorpyrifos-Oxon: A Widening Spectrum of Toxicity.
Kalenik S, Zaczek A, Rodacka A. Kalenik S, et al. Int J Mol Sci. 2026 Apr 28;27(9):3909. doi: 10.3390/ijms27093909. Int J Mol Sci. 2026. PMID: 42123501 Free PMC article. Review.
While traditionally characterized by its potent acetylcholinesterase-inhibitory properties, accumulating evidence now shows that chlorpyrifos and its bioactive metabolite, chlorpyrifos-oxon (CPO), exert far broader toxic effects, including the induction of oxidative …
While traditionally characterized by its potent acetylcholinesterase-inhibitory properties, accumulating evidence now shows that chlorpyrifo …
Chlorpyrifos Oxon Activates Glutamate and Lysine for Protein Cross-linking.
Muñoz-Torrero D, Schopfer LM, Lockridge O. Muñoz-Torrero D, et al. Chem Res Toxicol. 2023 Jan 16;36(1):112-121. doi: 10.1021/acs.chemrestox.2c00333. Epub 2023 Jan 4. Chem Res Toxicol. 2023. PMID: 36598934 Free PMC article.
To test this hypothesis, we treated MAP-rich tubulin Sus scrofa and human transglutaminase with chlorpyrifos oxon. Trypsin-digested proteins were subjected to liquid chromatography-tandem mass spectrometry followed by Protein Prospector searches to identify diethyl …
To test this hypothesis, we treated MAP-rich tubulin Sus scrofa and human transglutaminase with chlorpyrifos oxon. Trypsin-dig …
Neurotoxicity of chlorpyrifos and chlorpyrifos-oxon to Daphnia magna.
Maggio SA, Janney PK, Jenkins JJ. Maggio SA, et al. Chemosphere. 2021 Aug;276:130120. doi: 10.1016/j.chemosphere.2021.130120. Epub 2021 Mar 1. Chemosphere. 2021. PMID: 33706179
While CPF is capable of eliciting neurotoxic effects, chlorpyrifos-oxon (CPFO) is the primary neurotoxicant agent. Aquatic organisms bioactivate CPF to CPFO through the Cytochrome P450 phase I metabolic pathway following exposure to CPF. ...
While CPF is capable of eliciting neurotoxic effects, chlorpyrifos-oxon (CPFO) is the primary neurotoxicant agent. Aquatic org …
Chlorpyrifos-oxon induced neuronal cell death via endoplasmic reticulum stress-triggered apoptosis pathways.
Feng B, Lu J, Jiang W, Xu N, Sun W. Feng B, et al. Toxicol In Vitro. 2024 Dec;101:105939. doi: 10.1016/j.tiv.2024.105939. Epub 2024 Sep 7. Toxicol In Vitro. 2024. PMID: 39251113
In the present study, we investigated the impacts of chlorpyrifos-oxon (CPO), the major toxic CPF metabolite, on cell apoptosis, and explored possible mechanism associated with endoplasmic reticulum (ER) stress in SH-SY5Y cells. ...
In the present study, we investigated the impacts of chlorpyrifos-oxon (CPO), the major toxic CPF metabolite, on cell apoptosi …
Chlorpyrifos Oxon-Induced Isopeptide Bond Formation in Human Butyrylcholinesterase.
Biberoglu K, Tacal O, Schopfer LM, Lockridge O. Biberoglu K, et al. Molecules. 2020 Jan 25;25(3):533. doi: 10.3390/molecules25030533. Molecules. 2020. PMID: 31991818 Free PMC article.
Our goal was to identify the residues in the human butyrylcholinesterase (HuBChE) tetramer that were crosslinked following treatment with 1.5 mM chlorpyrifos oxon. High molecular weight bands were visualized on an SDS gel. Proteins in the gel bands were digested wit …
Our goal was to identify the residues in the human butyrylcholinesterase (HuBChE) tetramer that were crosslinked following treatment with 1. …
Glutathione in Chlorpyrifos-and Chlorpyrifos-Oxon-Induced Toxicity: a Comparative Study Focused on Non-cholinergic Toxicity in HT22 Cells.
Naime AA, Lopes MW, Colle D, Dafré AL, Suñol C, da Rocha JBT, Aschner M, Leal RB, Farina M. Naime AA, et al. Neurotox Res. 2020 Oct;38(3):603-610. doi: 10.1007/s12640-020-00254-5. Epub 2020 Jul 10. Neurotox Res. 2020. PMID: 32651842 Free article.
CPF-mediated neurotoxicity is mainly associated with its anticholinesterase activity, which may lead to a cholinergic syndrome. CPF metabolism generates chlorpyrifos-oxon (CPF-O), which possesses higher anticholinesterase activity and, consequently, plays a major ro …
CPF-mediated neurotoxicity is mainly associated with its anticholinesterase activity, which may lead to a cholinergic syndrome. CPF metaboli …
Chlorpyrifos-oxon results in autophagic flux dysfunction contributing to neuronal apoptosis via a ROS/AMPK/CHOP activation pathway.
Liu JM, Lee KI, Su CC, Fang KM, Liu SH, Fu SC, Kuo CY, Chang KC, Ke JA, Chen YW, Yang CY, Huang CF. Liu JM, et al. Chem Biol Interact. 2025 May 1;412:111452. doi: 10.1016/j.cbi.2025.111452. Epub 2025 Mar 4. Chem Biol Interact. 2025. PMID: 40049439
Chlorpyrifos (CPF) is a widely used organophosphate (OP) pesticide in agriculture and sanitation, known to elicit neurotoxic effects. Chlorpyrifos-oxon (CPO), a metabolite of CPF, is the primary neurotoxic agent, yet its mechanisms are less understood. ...
Chlorpyrifos (CPF) is a widely used organophosphate (OP) pesticide in agriculture and sanitation, known to elicit neurotoxic effects. Chl …
Corticosterone and chlorpyrifos oxon exposure elicits spatiotemporal MAPK phosphoprotein signaling in a mouse brain.
Penatzer JA, Prince N, Miller JV, Newman M, Lynch C, Hobbs GR, Boyd JW. Penatzer JA, et al. Food Chem Toxicol. 2021 Sep;155:112421. doi: 10.1016/j.fct.2021.112421. Epub 2021 Jul 16. Food Chem Toxicol. 2021. PMID: 34280473
To better represent this exposure scenario, a mouse model utilized exogenous administration of corticosterone (CORT; high physiologic stress mimic) in combination with chlorpyrifos oxon (CPO; oxon metabolite of CPF); this combination increases neuroinflammation post …
To better represent this exposure scenario, a mouse model utilized exogenous administration of corticosterone (CORT; high physiologic stress …
Chlorpyrifos oxon interacts with the mammalian multidrug resistance protein, P-glycoprotein.
Lanning CL, Fine RL, Sachs CW, Rao US, Corcoran JJ, Abou-Donia MB. Lanning CL, et al. J Toxicol Environ Health. 1996 Mar;47(4):395-407. doi: 10.1080/009841096161726. J Toxicol Environ Health. 1996. PMID: 8600291
A concentration-dependent inhibition of [3H]azidopine labeling of P-gp was detected with chlorpyrifos oxon, while significant inhibition was not detected with chlorpyrifos. To correlate the binding of chlorpyrifos oxon to P-gp with a biochemical effect …
A concentration-dependent inhibition of [3H]azidopine labeling of P-gp was detected with chlorpyrifos oxon, while significant …
431 results