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80 results

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Page 1
Pulmonary bacteriophage and cystic fibrosis airway mucus: friends or foes?
Ling KM, Stick SM, Kicic A. Ling KM, et al. Front Med (Lausanne). 2023 May 17;10:1088494. doi: 10.3389/fmed.2023.1088494. eCollection 2023. Front Med (Lausanne). 2023. PMID: 37265479 Free PMC article. Review.
One gathering significant traction is bacteriophage (phage) therapy. However, little is known about which phages are effective for respiratory infections, the dynamics involved between phage(s) and the host airway, and associated by-products, in …
One gathering significant traction is bacteriophage (phage) therapy. However, little is known about which phages are ef …
Pf Bacteriophage and Their Impact on Pseudomonas Virulence, Mammalian Immunity, and Chronic Infections.
Secor PR, Burgener EB, Kinnersley M, Jennings LK, Roman-Cruz V, Popescu M, Van Belleghem JD, Haddock N, Copeland C, Michaels LA, de Vries CR, Chen Q, Pourtois J, Wheeler TJ, Milla CE, Bollyky PL. Secor PR, et al. Front Immunol. 2020 Feb 21;11:244. doi: 10.3389/fimmu.2020.00244. eCollection 2020. Front Immunol. 2020. PMID: 32153575 Free PMC article. Review.
Pf bacteriophage are temperate phages that infect the bacterium Pseudomonas aeruginosa, a major cause of chronic lung infections in cystic fibrosis (CF) and other settings. Pf and other temperate phages have evolved complex, mutualistic relationships with the …
Pf bacteriophage are temperate phages that infect the bacterium Pseudomonas aeruginosa, a major cause of chronic lung infectio …
Within-Host Evolution of Bacterial Pathogens in Acute and Chronic Infection.
Dekker JP. Dekker JP. Annu Rev Pathol. 2024 Jan 24;19:203-226. doi: 10.1146/annurev-pathmechdis-051122-111408. Epub 2023 Oct 13. Annu Rev Pathol. 2024. PMID: 37832940 Free article. Review.
In some cases, elevated mutation rates resulting from mismatch repair or proofreading deficiencies accelerate evolution, and active mobile genetic elements or phages may facilitate genome plasticity. The host immune response provides another critical component of the fitne …
In some cases, elevated mutation rates resulting from mismatch repair or proofreading deficiencies accelerate evolution, and active mobile g …
Bacteriophage and Bacterial Susceptibility, Resistance, and Tolerance to Antibiotics.
Chen Q, Dharmaraj T, Cai PC, Burgener EB, Haddock NL, Spakowitz AJ, Bollyky PL. Chen Q, et al. Pharmaceutics. 2022 Jul 7;14(7):1425. doi: 10.3390/pharmaceutics14071425. Pharmaceutics. 2022. PMID: 35890320 Free PMC article. Review.
Recent studies using lytic bacteriophages to treat bacterial infections (phage therapy) demonstrate that phages can promote susceptibility to chemical antibiotics and that phage/antibiotic synergy is possible. ...In addition, chronic infectio …
Recent studies using lytic bacteriophages to treat bacterial infections (phage therapy) demonstrate that phages can pro …
Black box of phage-bacterium interactions: exploring alternative phage infection strategies.
Mäntynen S, Laanto E, Oksanen HM, Poranen MM, Díaz-Muñoz SL. Mäntynen S, et al. Open Biol. 2021 Sep;11(9):210188. doi: 10.1098/rsob.210188. Epub 2021 Sep 15. Open Biol. 2021. PMID: 34520699 Free PMC article. Review.
We propose distinct definitions for the terms 'pseudolysogeny' and 'productive or non-productive chronic infection', and distinguish them from the carrier state life cycle, which describes a population-level phenomenon. ...Moreover, we discuss potential implications …
We propose distinct definitions for the terms 'pseudolysogeny' and 'productive or non-productive chronic infection', and disti …
Phage Inhibit Pathogen Dissemination by Targeting Bacterial Migrants in a Chronic Infection Model.
Darch SE, Kragh KN, Abbott EA, Bjarnsholt T, Bull JJ, Whiteley M. Darch SE, et al. mBio. 2017 Apr 4;8(2):e00240-17. doi: 10.1128/mBio.00240-17. mBio. 2017. PMID: 28377527 Free PMC article.
We propose a model in which aggregates provide a mechanism that allows P. aeruginosa to tolerate phage therapy during chronic infection without the need for genetic mutation.IMPORTANCE Bacteria in chronic infections often reside in communities composed of mic …
We propose a model in which aggregates provide a mechanism that allows P. aeruginosa to tolerate phage therapy during chronic …
Toxin-antitoxin systems in bacterial pathogenesis.
Sonika S, Singh S, Mishra S, Verma S. Sonika S, et al. Heliyon. 2023 Mar 3;9(4):e14220. doi: 10.1016/j.heliyon.2023.e14220. eCollection 2023 Apr. Heliyon. 2023. PMID: 37101643 Free PMC article. Review.
Toxin-Antitoxin (TA) systems are abundant in prokaryotes and play an important role in various biological processes such as plasmid maintenance, phage inhibition, stress response, biofilm formation, and dormant persister cell generation. ...Several studies have reported th …
Toxin-Antitoxin (TA) systems are abundant in prokaryotes and play an important role in various biological processes such as plasmid maintena …
Capsid structure of bacteriophage phiKZ provides insights into assembly and stabilization of jumbo phages.
Yang Y, Shao Q, Guo M, Han L, Zhao X, Wang A, Li X, Wang B, Pan JA, Chen Z, Fokine A, Sun L, Fang Q. Yang Y, et al. Nat Commun. 2024 Aug 2;15(1):6551. doi: 10.1038/s41467-024-50811-1. Nat Commun. 2024. PMID: 39095371 Free PMC article.
Jumbo phages are a group of tailed bacteriophages with large genomes and capsids. As a prototype of jumbo phage, phiKZ infects Pseudomonas aeruginosa, a multi-drug-resistant (MDR) opportunistic pathogen leading to acute or chronic infection in i …
Jumbo phages are a group of tailed bacteriophages with large genomes and capsids. As a prototype of jumbo phage, phiKZ …
Improving Phage-Biofilm In Vitro Experimentation.
Abedon ST, Danis-Wlodarczyk KM, Wozniak DJ, Sullivan MB. Abedon ST, et al. Viruses. 2021 Jun 19;13(6):1175. doi: 10.3390/v13061175. Viruses. 2021. PMID: 34205417 Free PMC article.
Bacteriophages or phages, the viruses of bacteria, are abundant components of most ecosystems, including those where bacteria predominantly occupy biofilm niches. Understanding the phage impact on bacterial biofilms therefore can be crucial toward understandi …
Bacteriophages or phages, the viruses of bacteria, are abundant components of most ecosystems, including those where bacteria …
Pseudomonas aeruginosa Interstrain Dynamics and Selection of Hyperbiofilm Mutants during a Chronic Infection.
Gloag ES, Marshall CW, Snyder D, Lewin GR, Harris JS, Santos-Lopez A, Chaney SB, Whiteley M, Cooper VS, Wozniak DJ. Gloag ES, et al. mBio. 2019 Aug 13;10(4):e01698-19. doi: 10.1128/mBio.01698-19. mBio. 2019. PMID: 31409682 Free PMC article.
Here we used a porcine full-thickness burn wound model of chronic infection to study the evolutionary dynamics of diverse Pseudomonas aeruginosa infections. ...Interstrain interactions were also observed, where adapted variants acquired CRISPR-mediated immunity to …
Here we used a porcine full-thickness burn wound model of chronic infection to study the evolutionary dynamics of diverse Pseu …
80 results