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159 results

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Page 1
Dicyclohexyl phthalate blocks Leydig cell regeneration in adult rat testis.
Lv Y, Fang Y, Chen P, Duan Y, Huang T, Ma L, Xie L, Chen X, Chen X, Gao J, Ge RS. Lv Y, et al. Toxicology. 2019 Jan 1;411:60-70. doi: 10.1016/j.tox.2018.10.020. Epub 2018 Nov 1. Toxicology. 2019. PMID: 30391266
Dicyclohexyl phthalate (DCHP) is a phthalate plasticizer with a ring structure in the alcohol moiety. ...
Dicyclohexyl phthalate (DCHP) is a phthalate plasticizer with a ring structure in the alcohol moiety. ...
Dicyclohexyl phthalate derails trophoblast function and lipid metabolism through NDRG1 by targeting PPARalpha:RXRalpha.
Zhang Y, Geng Y, Zhang Y, Ma Y, Yin X, Chen Z, Mu X, Gao R, Chen X, Li F, He J. Zhang Y, et al. Toxicology. 2025 Jun;514:154124. doi: 10.1016/j.tox.2025.154124. Epub 2025 Mar 27. Toxicology. 2025. PMID: 40157530
Phthalates (PAEs) can impair trophoblast cell and subsequent placental development, adversely affecting pregnancy. The effects of dicyclohexyl phthalate (DCHP), the main PAE homologue in urban household dust, on trophoblast function and placental development are unk …
Phthalates (PAEs) can impair trophoblast cell and subsequent placental development, adversely affecting pregnancy. The effects of dicyclo …
Effects of Dicyclohexyl Phthalate Exposure on PXR Activation and Lipid Homeostasis in Mice.
Sui Y, Meng Z, Chen J, Liu J, Hernandez R, Gonzales MB, Gwag T, Morris AJ, Zhou C. Sui Y, et al. Environ Health Perspect. 2021 Dec;129(12):127001. doi: 10.1289/EHP9262. Epub 2021 Dec 1. Environ Health Perspect. 2021. PMID: 34851150 Free PMC article.
OBJECTIVE: We sought to investigate the contribution of PXR to the adverse effects dicyclohexyl phthalate (DCHP), a widely used phthalate plasticizer, on lipid homeostasis and CVD risk factors. ...
OBJECTIVE: We sought to investigate the contribution of PXR to the adverse effects dicyclohexyl phthalate (DCHP), a widely use …
Identification of dicyclohexyl phthalate as a glucocorticoid receptor antagonist by molecular docking and multiple in vitro methods.
Leng Y, Sun Y, Huang W, Lv C, Cui J, Li T, Wang Y. Leng Y, et al. Mol Biol Rep. 2021 Apr;48(4):3145-3154. doi: 10.1007/s11033-021-06303-2. Epub 2021 Apr 21. Mol Biol Rep. 2021. PMID: 33881729
Luciferase reporter gene assay revealed that the tested chemicals displayed no agonistic effects but dicyclohexyl phthalate (DCHP) exerted antagonistic activity in a dose-responsive manner for GR in HeLa cells. ...
Luciferase reporter gene assay revealed that the tested chemicals displayed no agonistic effects but dicyclohexyl phthalate (D …
Effects of the in-utero dicyclohexyl phthalate and di-n-hexyl phthalate administration on the oxidative stress-induced histopathological changes in the rat liver tissue correlated with serum biochemistry and hematological parameters.
Aydemir D, Aydogan-Ahbab M, Barlas N, Ulusu NN. Aydemir D, et al. Front Endocrinol (Lausanne). 2023 May 19;14:1128202. doi: 10.3389/fendo.2023.1128202. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 37274322 Free PMC article.
We found increased relative and absolute liver weights and impaired triglyceride, alanine transaminase (ALT), lactate dehydrogenase (LDH), and alkaline phosphatase (ALP) levels upon dicyclohexyl phthalate (DCHP) and di-n-hexyl phthalate (DHP). Histopathological chan …
We found increased relative and absolute liver weights and impaired triglyceride, alanine transaminase (ALT), lactate dehydrogenase (LDH), a …
Pregnane X Receptor Mediates Atherosclerosis Induced by Dicyclohexyl Phthalate in LDL Receptor-Deficient Mice.
Liu J, Hernandez R, Li X, Meng Z, Chen H, Zhou C. Liu J, et al. Cells. 2022 Mar 26;11(7):1125. doi: 10.3390/cells11071125. Cells. 2022. PMID: 35406689 Free PMC article.
Plastic-associated endocrine disrupting chemicals (EDCs) have been implicated in the etiology of cardiovascular disease (CVD) in humans, but the underlying mechanisms remain elusive. Dicyclohexyl phthalate (DCHP) is a widely used phthalate plasticizer; whether and h …
Plastic-associated endocrine disrupting chemicals (EDCs) have been implicated in the etiology of cardiovascular disease (CVD) in humans, but …
Comparative developmental toxicity evaluation of di- n-hexyl phthalate and dicyclohexyl phthalate in rats.
Ahbab MA, Güven C, Koçkaya EA, Barlas N. Ahbab MA, et al. Toxicol Ind Health. 2017 Sep;33(9):696-716. doi: 10.1177/0748233717711868. Epub 2017 Aug 31. Toxicol Ind Health. 2017. PMID: 28854868
To investigate the effects of di- n-hexyl phthalate (DHP) and dicyclohexyl phthalate (DCHP) on the development of fetus and placenta in utero, pregnant rats were exposed to DHP or DCHP at dosages of 0, 20, 100, and 500 mg/kg bw/day, by gavage, on gestational days 6- …
To investigate the effects of di- n-hexyl phthalate (DHP) and dicyclohexyl phthalate (DCHP) on the development of fetus and pl …
Influence of in utero di-n-hexyl phthalate and dicyclohexyl phthalate on fetal testicular development in rats.
Aydoğan Ahbab M, Barlas N. Aydoğan Ahbab M, et al. Toxicol Lett. 2015 Mar 4;233(2):125-37. doi: 10.1016/j.toxlet.2015.01.015. Epub 2015 Jan 28. Toxicol Lett. 2015. PMID: 25637754
This study investigated the effects of di-n-hexyl phthalate (DHP) and dicyclohexyl phthalate (DCHP) on male reproductive development in utero. Pregnant rats were exposed to DHP and DCHP at doses of 0 (vehicle), 20, 100 and 500mg/kg/day, by gavage, on gestational day …
This study investigated the effects of di-n-hexyl phthalate (DHP) and dicyclohexyl phthalate (DCHP) on male reproductive devel …
In utero exposure to dicyclohexyl and di-n-hexyl phthalate possess genotoxic effects on testicular cells of male rats after birth in the comet and TUNEL assays.
Ahbab MA, Ündeğer Ü, Barlas N, Başaran N. Ahbab MA, et al. Hum Exp Toxicol. 2014 Mar;33(3):230-9. doi: 10.1177/0960327113494903. Epub 2013 Jul 8. Hum Exp Toxicol. 2014. PMID: 23836838
The aim of this study is therefore to evaluate possible genotoxicity of di-n-hexyl phthalate (DHP) and dicyclohexyl phthalate (DCHP) at different concentrations using single-cell gel electrophoresis (comet) and terminal deoxynucleotidyl transferase deoxyuridine trip …
The aim of this study is therefore to evaluate possible genotoxicity of di-n-hexyl phthalate (DHP) and dicyclohexyl phthalate …
Comprehensive insights into the interactions of dicyclohexyl phthalate and its metabolite to human serum albumin.
Lv X, Jiang Z, Zeng G, Zhao S, Li N, Chen F, Huang X, Yao J, Tuo X. Lv X, et al. Food Chem Toxicol. 2021 Sep;155:112407. doi: 10.1016/j.fct.2021.112407. Epub 2021 Jul 14. Food Chem Toxicol. 2021. PMID: 34273427
Phthalate esters (PAEs) are a type of persistent organic pollutants and have received widespread concerns due to their adverse effects on human health. Dicyclohexyl phthalate (DCHP) and its metabolite monocyclohexyl phthalate (MCHP) were selected to explore the mech …
Phthalate esters (PAEs) are a type of persistent organic pollutants and have received widespread concerns due to their adverse effects on hu …
159 results