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84 results

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Quoted phrase not found in phrase index: "steoroids"
Page 1
Amplification of Protein Expression by Self-Amplifying mRNA Delivered in Lipid Nanoparticles Containing a β-Aminoester Ionizable Lipid Correlates with Reduced Innate Immune Activation.
De Lombaerde E, Cui X, Chen Y, Zhong Z, Deckers J, Mencarelli G, Opsomer L, Wang H, De Baere J, Lienenklaus S, Lambrecht BN, Sanders NN, De Geest BG. De Lombaerde E, et al. ACS Nano. 2024 Oct 15;18(41):28311-28324. doi: 10.1021/acsnano.4c09677. Epub 2024 Oct 1. ACS Nano. 2024. PMID: 39352021
In this study, we report on a class of beta-aminoester lipids (betaAELs) synthesized through the Michael addition of an acrylate to diethanolamine, followed by esterification with fatty acids. These lipids possessed one or two ionizable amines, depending on the use of noni …
In this study, we report on a class of beta-aminoester lipids (betaAELs) synthesized through the Michael addition of an acrylate to dieth …
Cosmetics use and age at menopause: is there a connection?
Chow ET, Mahalingaiah S. Chow ET, et al. Fertil Steril. 2016 Sep 15;106(4):978-90. doi: 10.1016/j.fertnstert.2016.08.020. Epub 2016 Aug 18. Fertil Steril. 2016. PMID: 27545020 Free PMC article. Review.
A review of the ingredients in the best-selling and top-rated products of the top beauty brands in the world, as well as a review of highlighted chemicals by nonprofit environmental organizations, reveals 11 chemicals and chemical families of concern: butylated hydroxyanisole/but …
A review of the ingredients in the best-selling and top-rated products of the top beauty brands in the world, as well as a review of highlig …
Age-related vaginal microecology and infection epidemiology among premenopausal and postmenopausal gynecologic outpatients: a cross-sectional study.
Lin W, Wang L, Dong B, Zhang Y, Zhang Y, Wang L, Shen J, Lu Y, Zheng M, Sun P. Lin W, et al. Front Cell Infect Microbiol. 2025 Aug 4;15:1569667. doi: 10.3389/fcimb.2025.1569667. eCollection 2025. Front Cell Infect Microbiol. 2025. PMID: 40831702 Free PMC article.
BACKGROUND: Postmenopausal estrogen deficiency disrupts vaginal microecological balance. This cross-sectional study investigates the epidemiology of vaginal infections and alterations in microbiota composition, enzymes, and metabolites among premenopausal and postmenopausa …
BACKGROUND: Postmenopausal estrogen deficiency disrupts vaginal microecological balance. This cross-sectional study investigates the …
Preterm birth is associated with xenobiotics and predicted by the vaginal metabolome.
Kindschuh WF, Baldini F, Liu MC, Liao J, Meydan Y, Lee HH, Heinken A, Thiele I, Thaiss CA, Levy M, Korem T. Kindschuh WF, et al. Nat Microbiol. 2023 Feb;8(2):246-259. doi: 10.1038/s41564-022-01293-8. Epub 2023 Jan 12. Nat Microbiol. 2023. PMID: 36635575 Free PMC article.
We find multiple associations between vaginal metabolites and subsequent preterm birth, and propose that several of these metabolites, including diethanolamine and ethyl glucoside, are exogenous. We observe associations between the metabolome and microbiome profiles previo …
We find multiple associations between vaginal metabolites and subsequent preterm birth, and propose that several of these metabolites, inclu …
Second trimester short cervix is associated with decreased abundance of cervicovaginal lipid metabolites.
Gerson KD, Yang N, Anton L, Levy M, Ravel J, Elovitz MA, Burris HH. Gerson KD, et al. Am J Obstet Gynecol. 2022 Aug;227(2):273.e1-273.e18. doi: 10.1016/j.ajog.2022.04.031. Epub 2022 Apr 22. Am J Obstet Gynecol. 2022. PMID: 35469813 Free PMC article.
STUDY DESIGN: This was a secondary analysis of a completed prospective pregnancy cohort. Cervicovaginal fluid was obtained between 20 and 24 weeks' gestation. ...Of the 637 metabolites detected, 26 differed between those with a short cervix and those with normal cervical l …
STUDY DESIGN: This was a secondary analysis of a completed prospective pregnancy cohort. Cervicovaginal fluid was obtained between 20 …
Design, synthesis and evaluation of novel phenothiazine derivatives as inhibitors of breast cancer stem cells.
Gao Y, Sun TY, Bai WF, Bai CG. Gao Y, et al. Eur J Med Chem. 2019 Dec 1;183:111692. doi: 10.1016/j.ejmech.2019.111692. Epub 2019 Sep 11. Eur J Med Chem. 2019. PMID: 31541872 Review.
A novel series of phenothiazine derivatives containing diethanolamine, methoxyethylamine, flavonoids, and a nitric oxide (NO) donor was designed and synthesized for the treatment of breast cancer. ...
A novel series of phenothiazine derivatives containing diethanolamine, methoxyethylamine, flavonoids, and a nitric oxide (NO) donor w …
Rational design, synthesis, antiproliferative activity against MCF-7, MDA-MB-231 cells, estrogen receptors binding affinity, and computational study of indenopyrimidine-2,5-dione analogs for the treatment of breast cancer.
Ejaz I, Javed MA, Jan MS, Ikram M, Sadiq A, Ahmad S, Rashid U. Ejaz I, et al. Bioorg Med Chem Lett. 2022 May 15;64:128668. doi: 10.1016/j.bmcl.2022.128668. Epub 2022 Mar 8. Bioorg Med Chem Lett. 2022. PMID: 35276362
Compounds with high antiproliferative activity against MCF-7 breast cancer cells were found devoid of cytotoxicity against HEK-293 cells. Competitive binding assay of estrogen receptors ERalpha and ERbeta showed that diethanolamine derivative of 4-trif …
Compounds with high antiproliferative activity against MCF-7 breast cancer cells were found devoid of cytotoxicity against HEK-293 ce …
Differential diagnosis of lung cancer and benign lung lesion using salivary metabolites: A preliminary study.
Takamori S, Ishikawa S, Suzuki J, Oizumi H, Uchida T, Ueda S, Edamatsu K, Iino M, Sugimoto M. Takamori S, et al. Thorac Cancer. 2022 Feb;13(3):460-465. doi: 10.1111/1759-7714.14282. Epub 2021 Dec 16. Thorac Cancer. 2022. PMID: 34918488 Free PMC article.
In this study, we aimed to identify salivary biomarkers for distinguishing lung cancer (LC) from benign lung lesion (BLL). MATERIALS AND METHODS: Unstimulated saliva samples were collected from 41 patients with LC and 21 with BLL. ...Furthermore, from the MLR model develop …
In this study, we aimed to identify salivary biomarkers for distinguishing lung cancer (LC) from benign lung lesion (BLL). MATERIALS …
ToxCast chemical library Wnt screen identifies diethanolamine as an activator of neural progenitor proliferation.
Wolter JM, Jimenez JA, Stein JL, Zylka MJ. Wolter JM, et al. FASEB Bioadv. 2022 Mar 28;4(7):441-453. doi: 10.1096/fba.2021-00163. eCollection 2022 Jul. FASEB Bioadv. 2022. PMID: 35812078 Free PMC article.
Additionally, valproic acid, which modulates Wnt signaling, increases risk for ASD when taken during pregnancy. We previously found that an autism-linked gain-of-function UBE3A (T485A) mutant construct hyperactivated canonical Wnt signaling, providing a genetic means to el …
Additionally, valproic acid, which modulates Wnt signaling, increases risk for ASD when taken during pregnancy. We previously found t …
Xenobiotic metabolites modify immune responses of the cervicovaginal epithelium: potential mechanisms underlying barrier disruption.
Gerson KD, Loder A, Landau Z, Anton L. Gerson KD, et al. BJOG. 2024 Apr;131(5):665-674. doi: 10.1111/1471-0528.17654. Epub 2023 Sep 13. BJOG. 2024. PMID: 37705143
OBJECTIVE: Xenobiotic metabolites are exogenous biochemicals that can adversely impact reproductive health. We previously identified xenobiotics in cervicovaginal fluid during pregnancy in association with short cervix. ...Future work identifying xenobiotic sources …
OBJECTIVE: Xenobiotic metabolites are exogenous biochemicals that can adversely impact reproductive health. We previously identified …
84 results