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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1960 1
1962 1
1989 1
1990 4
1991 4
1992 12
1993 7
1994 8
1995 9
1996 13
1997 10
1998 16
1999 5
2000 19
2001 6
2002 14
2003 8
2004 14
2005 11
2006 16
2007 15
2008 17
2009 20
2010 24
2011 24
2012 20
2013 23
2014 17
2015 25
2016 23
2017 28
2018 35
2019 17
2020 0
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430 results
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Page 1
Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia.
Sykes DB, Kfoury YS, Mercier FE, Wawer MJ, Law JM, Haynes MK, Lewis TA, Schajnovitz A, Jain E, Lee D, Meyer H, Pierce KA, Tolliday NJ, Waller A, Ferrara SJ, Eheim AL, Stoeckigt D, Maxcy KL, Cobert JM, Bachand J, Szekely BA, Mukherjee S, Sklar LA, Kotz JD, Clish CB, Sadreyev RI, Clemons PA, Janzer A, Schreiber SL, Scadden DT. Sykes DB, et al. Cell. 2016 Sep 22;167(1):171-186.e15. doi: 10.1016/j.cell.2016.08.057. Epub 2016 Sep 15. Cell. 2016. PMID: 27641501 Free article.
Targeting dihydroorotate dehydrogenase in acute myeloid leukemia.
Zeng Z, Konopleva M. Zeng Z, et al. Haematologica. 2018 Sep;103(9):1415-1417. doi: 10.3324/haematol.2018.197806. Haematologica. 2018. PMID: 30171015 Free PMC article. No abstract available.
Pharmacological inhibition of dihydroorotate dehydrogenase induces apoptosis and differentiation in acute myeloid leukemia cells.
Wu D, Wang W, Chen W, Lian F, Lang L, Huang Y, Xu Y, Zhang N, Chen Y, Liu M, Nussinov R, Cheng F, Lu W, Huang J. Wu D, et al. Haematologica. 2018 Sep;103(9):1472-1483. doi: 10.3324/haematol.2018.188185. Epub 2018 Jun 7. Haematologica. 2018. PMID: 29880605 Free PMC article.
The novel dihydroorotate dehydrogenase (DHODH) inhibitor BAY 2402234 triggers differentiation and is effective in the treatment of myeloid malignancies.
Christian S, Merz C, Evans L, Gradl S, Seidel H, Friberg A, Eheim A, Lejeune P, Brzezinka K, Zimmermann K, Ferrara S, Meyer H, Lesche R, Stoeckigt D, Bauser M, Haegebarth A, Sykes DB, Scadden DT, Losman JA, Janzer A. Christian S, et al. Leukemia. 2019 Oct;33(10):2403-2415. doi: 10.1038/s41375-019-0461-5. Epub 2019 Apr 2. Leukemia. 2019. PMID: 30940908
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