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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2004 2
2005 2
2006 1
2007 3
2008 5
2009 16
2010 30
2011 74
2012 91
2013 185
2014 267
2015 353
2016 460
2017 501
2018 698
2019 851
2020 790
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3,930 results
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Page 1
Drug repositioning and repurposing: terminology and definitions in literature.
Langedijk J, Mantel-Teeuwisse AK, Slijkerman DS, Schutjens MH. Langedijk J, et al. Drug Discov Today. 2015 Aug;20(8):1027-34. doi: 10.1016/j.drudis.2015.05.001. Epub 2015 May 11. Drug Discov Today. 2015. PMID: 25975957 Review.
Drug repositioning and similar terms have been a trending topic in literature and represent novel drug development strategies. ...In total, 217 articles referred to 'drug repositioning', 'drug repurposing', 'drug reprofiling
Drug repositioning and similar terms have been a trending topic in literature and represent novel drug development stra
Drug repurposing from the perspective of pharmaceutical companies.
Cha Y, Erez T, Reynolds IJ, Kumar D, Ross J, Koytiger G, Kusko R, Zeskind B, Risso S, Kagan E, Papapetropoulos S, Grossman I, Laifenfeld D. Cha Y, et al. Br J Pharmacol. 2018 Jan;175(2):168-180. doi: 10.1111/bph.13798. Epub 2017 May 18. Br J Pharmacol. 2018. PMID: 28369768 Free PMC article. Review.
In recent years, the need for new approaches to drug research and development, combined with the advent of big data repositories and associated analytical methods, has generated interest in developing systematic approaches to drug repurposing. ...LINKED ARTIC …
In recent years, the need for new approaches to drug research and development, combined with the advent of big data repositories and …
Drug Repurposing in Parkinson's Disease.
Athauda D, Foltynie T. Athauda D, et al. CNS Drugs. 2018 Aug;32(8):747-761. doi: 10.1007/s40263-018-0548-y. CNS Drugs. 2018. PMID: 30066310 Review.
Given the number of failures of various novel interventions in disease-modifying clinical trials in combination with the ever-increasing costs and lengthy processes for drug development, attention is being turned to utilizing existing compounds approved for other indicatio …
Given the number of failures of various novel interventions in disease-modifying clinical trials in combination with the ever-increasing cos …
Review of Drug Repositioning Approaches and Resources.
Xue H, Li J, Xie H, Wang Y. Xue H, et al. Int J Biol Sci. 2018 Jul 13;14(10):1232-1244. doi: 10.7150/ijbs.24612. eCollection 2018. Int J Biol Sci. 2018. PMID: 30123072 Free PMC article. Review.
Drug discovery is a time-consuming, high-investment, and high-risk process in traditional drug development. Drug repositioning has become a popular strategy in recent years. ...Furthermore, we summarized 76 important resources about drug repo
Drug discovery is a time-consuming, high-investment, and high-risk process in traditional drug development. Drug rep
Drug repurposing in cancer.
Sleire L, Førde HE, Netland IA, Leiss L, Skeie BS, Enger PØ. Sleire L, et al. Pharmacol Res. 2017 Oct;124:74-91. doi: 10.1016/j.phrs.2017.07.013. Epub 2017 Jul 13. Pharmacol Res. 2017. PMID: 28712971 Review.
This unmet need for more effective anti-cancer drugs has sparked a growing interest for drug repurposing, i.e. using drugs already approved for other indications to treat cancer. ...Here, we provide an overview of promising candidates for drug repurposing
This unmet need for more effective anti-cancer drugs has sparked a growing interest for drug repurposing, i.e. using drugs alr …
Drug repurposing with network reinforcement.
Nam Y, Kim M, Chang HS, Shin H. Nam Y, et al. BMC Bioinformatics. 2019 Jul 24;20(Suppl 13):383. doi: 10.1186/s12859-019-2858-6. BMC Bioinformatics. 2019. PMID: 31337333 Free PMC article.
BACKGROUND: Drug repurposing has been motivated to ameliorate low probability of success in drug discovery. For the recent decade, many in silico attempts have received primary attention as a first step to alleviate the high cost and longevity. ...Utilizing t …
BACKGROUND: Drug repurposing has been motivated to ameliorate low probability of success in drug discovery. For the rec …
Drug Repurposing for Viral Infectious Diseases: How Far Are We?
Mercorelli B, Palù G, Loregian A. Mercorelli B, et al. Trends Microbiol. 2018 Oct;26(10):865-876. doi: 10.1016/j.tim.2018.04.004. Epub 2018 May 11. Trends Microbiol. 2018. PMID: 29759926 Free PMC article. Review.
In the past years, drug repurposing combined with innovative approaches for drug validation, and with appropriate animal models, significantly contributed to the identification of new antiviral molecules and targets for therapeutic intervention. In this revie …
In the past years, drug repurposing combined with innovative approaches for drug validation, and with appropriate anima …
Drug repurposing for antimicrobial discovery.
Farha MA, Brown ED. Farha MA, et al. Nat Microbiol. 2019 Apr;4(4):565-577. doi: 10.1038/s41564-019-0357-1. Epub 2019 Mar 4. Nat Microbiol. 2019. PMID: 30833727 Review.
The ongoing need to develop new antimicrobial drugs that are effective against multi-drug-resistant pathogens has spurred the research community to invest in various drug discovery strategies, one of which is drug repurposing-the process of finding new …
The ongoing need to develop new antimicrobial drugs that are effective against multi-drug-resistant pathogens has spurred the researc …
A review of computational drug repurposing.
Park K. Park K. Transl Clin Pharmacol. 2019 Jun;27(2):59-63. doi: 10.12793/tcp.2019.27.2.59. Epub 2019 Jun 28. Transl Clin Pharmacol. 2019. PMID: 32055582 Free PMC article. Review.
In view of these circumstances, 'drug repurposing' (or 'drug repositioning') has appeared as an alternative tool to accelerate drug development process by seeking new indications for already approved drugs rather than discovering de novo drug
In view of these circumstances, 'drug repurposing' (or 'drug repositioning') has appeared as an alternative tool …
Drug repurposing: progress, challenges and recommendations.
Pushpakom S, Iorio F, Eyers PA, Escott KJ, Hopper S, Wells A, Doig A, Guilliams T, Latimer J, McNamee C, Norris A, Sanseau P, Cavalla D, Pirmohamed M. Pushpakom S, et al. Nat Rev Drug Discov. 2019 Jan;18(1):41-58. doi: 10.1038/nrd.2018.168. Epub 2018 Oct 12. Nat Rev Drug Discov. 2019. PMID: 30310233 Review.
Given the high attrition rates, substantial costs and slow pace of new drug discovery and development, repurposing of 'old' drugs to treat both common and rare diseases is increasingly becoming an attractive proposition because it involves the use of de-risked compo …
Given the high attrition rates, substantial costs and slow pace of new drug discovery and development, repurposing of 'old' dr …
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