Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2001 1
2002 1
2003 2
2004 8
2005 7
2006 25
2007 15
2008 24
2009 19
2010 28
2011 19
2012 25
2013 25
2014 33
2015 51
2016 45
2017 29
2018 23
2019 18
2020 10
2021 11
2022 9
2023 4
2024 3
2025 8
2026 5

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

398 results

Results by year

Filters applied: . Clear all
Page 1
Early goal-directed therapy in the treatment of severe sepsis and septic shock.
Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, Peterson E, Tomlanovich M; Early Goal-Directed Therapy Collaborative Group. Rivers E, et al. N Engl J Med. 2001 Nov 8;345(19):1368-77. doi: 10.1056/NEJMoa010307. N Engl J Med. 2001. PMID: 11794169 Free article. Clinical Trial.
The purpose of this study was to evaluate the efficacy of early goal-directed therapy before admission to the intensive care unit. METHODS: We randomly assigned patients who arrived at an urban emergency department with severe sepsis or septic …
The purpose of this study was to evaluate the efficacy of early goal-directed therapy before admission to the in …
Septic shock: Past, present, and perspectives.
Plata-Menchaca EP, Pérez-Nieto OR, Kattan E, Iba T, Ferrer R. Plata-Menchaca EP, et al. J Crit Care. 2026 Feb;91:155269. doi: 10.1016/j.jcrc.2025.155269. Epub 2025 Sep 18. J Crit Care. 2026. PMID: 40972498 Review.
Septic shock remains one of the most severe complications of infection, defined by circulatory, cellular, and metabolic dysfunction and associated with persistently high mortality. ...Consensus definitions and large clinical trials, including early goal …
Septic shock remains one of the most severe complications of infection, defined by circulatory, cellular, and metabolic dysfun …
Early, Goal-Directed Therapy for Septic Shock - A Patient-Level Meta-Analysis.
PRISM Investigators; Rowan KM, Angus DC, Bailey M, Barnato AE, Bellomo R, Canter RR, Coats TJ, Delaney A, Gimbel E, Grieve RD, Harrison DA, Higgins AM, Howe B, Huang DT, Kellum JA, Mouncey PR, Music E, Peake SL, Pike F, Reade MC, Sadique MZ, Singer M, Yealy DM. PRISM Investigators, et al. N Engl J Med. 2017 Jun 8;376(23):2223-2234. doi: 10.1056/NEJMoa1701380. Epub 2017 Mar 21. N Engl J Med. 2017. PMID: 28320242 Free article.
BACKGROUND: After a single-center trial and observational studies suggesting that early, goal-directed therapy (EGDT) reduced mortality from septic shock, three multicenter trials (ProCESS, ARISE, and ProMISe) showed no benefit. ...Subgro …
BACKGROUND: After a single-center trial and observational studies suggesting that early, goal-directed therapy ( …
Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis.
Seymour CW, Kennedy JN, Wang S, Chang CH, Elliott CF, Xu Z, Berry S, Clermont G, Cooper G, Gomez H, Huang DT, Kellum JA, Mi Q, Opal SM, Talisa V, van der Poll T, Visweswaran S, Vodovotz Y, Weiss JC, Yealy DM, Yende S, Angus DC. Seymour CW, et al. JAMA. 2019 May 28;321(20):2003-2017. doi: 10.1001/jama.2019.5791. JAMA. 2019. PMID: 31104070 Free PMC article.
Of the 4 derived phenotypes, the alpha phenotype was the most common (n = 6625; 33%) and included patients with the lowest administration of a vasopressor; in the beta phenotype (n = 5512; 27%), patients were older and had more chronic illness and renal dysfunction; in the gamma …
Of the 4 derived phenotypes, the alpha phenotype was the most common (n = 6625; 33%) and included patients with the lowest administration of …
Hemodynamic monitoring and management of pediatric septic shock.
Lee EP, Wu HP, Chan OW, Lin JJ, Hsia SH. Lee EP, et al. Biomed J. 2022 Feb;45(1):63-73. doi: 10.1016/j.bj.2021.10.004. Epub 2021 Oct 12. Biomed J. 2022. PMID: 34653683 Free PMC article. Review.
Hemodynamics in sepsis can be divided into two groups: basic and advanced hemodynamic parameters. Previous therapeutic guidance of early-goal directed therapy (EGDT), which resuscitated based on the basic hemodynamics (central venous pressure and centr …
Hemodynamics in sepsis can be divided into two groups: basic and advanced hemodynamic parameters. Previous therapeutic guidance of early …
Goal-directed resuscitation for patients with early septic shock.
ARISE Investigators; ANZICS Clinical Trials Group; Peake SL, Delaney A, Bailey M, Bellomo R, Cameron PA, Cooper DJ, Higgins AM, Holdgate A, Howe BD, Webb SA, Williams P. ARISE Investigators, et al. N Engl J Med. 2014 Oct 16;371(16):1496-506. doi: 10.1056/NEJMoa1404380. Epub 2014 Oct 1. N Engl J Med. 2014. PMID: 25272316 Free article. Clinical Trial.
BACKGROUND: Early goal-directed therapy (EGDT) has been endorsed in the guidelines of the Surviving Sepsis Campaign as a key strategy to decrease mortality among patients presenting to the emergency department with septic shock. ...METHOD …
BACKGROUND: Early goal-directed therapy (EGDT) has been endorsed in the guidelines of the Surviving Sepsis Campa …
Efficacy of Early Goal-Directed Therapy in Septic Shock Management: A Systematic Review.
Acharya P, Virani S, Afreen S, Perthiani A, Sangster E, Lanka N, Malasevskaia I. Acharya P, et al. Cureus. 2024 Nov 24;16(11):e74358. doi: 10.7759/cureus.74358. eCollection 2024 Nov. Cureus. 2024. PMID: 39720373 Free PMC article. Review.
Septic shock is a serious and life-threatening illness marked by potentially fatal and metabolic abnormalities, leading to high mortality rates in adult patients. Early goal-directed therapy (EGDT) was introduced as a systematic approach …
Septic shock is a serious and life-threatening illness marked by potentially fatal and metabolic abnormalities, leading to hig …
Severe Sepsis and Septic Shock Trials (ProCESS, ARISE, ProMISe): What is Optimal Resuscitation?
Osborn TM. Osborn TM. Crit Care Clin. 2017 Apr;33(2):323-344. doi: 10.1016/j.ccc.2016.12.004. Crit Care Clin. 2017. PMID: 28284298 Review.
Between 2014 and 2015, 3 independent, multicenter, randomized controlled trials evaluated early goal-directed therapy (EGDT) in severe sepsis and septic shock: Protocolized Care for Early Septic Shock (ProCESS) from the Unit …
Between 2014 and 2015, 3 independent, multicenter, randomized controlled trials evaluated early goal-directed therap …
Management of Sepsis and Septic Shock: What Have We Learned in the Last Two Decades?
Kamath S, Hammad Altaq H, Abdo T. Kamath S, et al. Microorganisms. 2023 Sep 4;11(9):2231. doi: 10.3390/microorganisms11092231. Microorganisms. 2023. PMID: 37764075 Free PMC article. Review.
Sepsis is a clinical syndrome encompassing physiologic and biological abnormalities caused by a dysregulated host response to infection. Sepsis progression into septic shock is associated with a dramatic increase in mortality, hence the importance of early identific …
Sepsis is a clinical syndrome encompassing physiologic and biological abnormalities caused by a dysregulated host response to infection. Sep …
A randomized trial of protocol-based care for early septic shock.
ProCESS Investigators; Yealy DM, Kellum JA, Huang DT, Barnato AE, Weissfeld LA, Pike F, Terndrup T, Wang HE, Hou PC, LoVecchio F, Filbin MR, Shapiro NI, Angus DC. ProCESS Investigators, et al. N Engl J Med. 2014 May 1;370(18):1683-93. doi: 10.1056/NEJMoa1401602. Epub 2014 Mar 18. N Engl J Med. 2014. PMID: 24635773 Free PMC article. Clinical Trial.
BACKGROUND: In a single-center study published more than a decade ago involving patients presenting to the emergency department with severe sepsis and septic shock, mortality was markedly lower among those who were treated according to a 6-hour protocol of early …
BACKGROUND: In a single-center study published more than a decade ago involving patients presenting to the emergency department with severe …
398 results