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Year Number of Results
1971 1
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1980 5
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1986 5
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1994 10
1995 5
1996 5
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2002 7
2003 10
2004 13
2005 12
2006 12
2007 15
2008 14
2009 6
2010 11
2011 22
2012 11
2013 13
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2016 17
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403 results

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Quoted phrase not found in phrase index: "steoroids"
Page 1
Cancer Chemotherapy via Natural Bioactive Compounds.
Pathak K, Pathak MP, Saikia R, Gogoi U, Sahariah JJ, Zothantluanga JH, Samanta A, Das A. Pathak K, et al. Curr Drug Discov Technol. 2022;19(4):e310322202888. doi: 10.2174/1570163819666220331095744. Curr Drug Discov Technol. 2022. PMID: 35362385 Review.
BACKGROUND: Cancer-induced mortality is increasingly prevalent globally, which skyrocketed the necessity to discover new/novel, safe and effective anticancer drugs. Cancer is characterized by the continuous multiplication of cells in the human, which is unable to co …
BACKGROUND: Cancer-induced mortality is increasingly prevalent globally, which skyrocketed the necessity to discover new/novel, safe …
Bioactivities and Action Mechanisms of Ellipticine Derivatives Reported Prior to 2023.
Hou W, Xu XL, Huang LJ, Zhang ZY, Zhou ZN, Wang JY, Ouyang X, Xin SY, Zhang ZY, Xiong Y, Huang H, Lan JX. Hou W, et al. Chem Biodivers. 2024 May;21(5):e202400210. doi: 10.1002/cbdv.202400210. Epub 2024 Apr 17. Chem Biodivers. 2024. PMID: 38433548 Review.
Ellipticine and its derivatives are characterized by multiple biological activities. The purpose of this review was to provide a critical and systematic assessment of ellipticine and its derivatives as bioactive molecules over the last 60 years. ...We have reviewed …
Ellipticine and its derivatives are characterized by multiple biological activities. The purpose of this review was to provide a crit …
Ellipticines as DNA-targeted chemotherapeutics.
Stiborová M, Frei E. Stiborová M, et al. Curr Med Chem. 2014;21(5):575-91. doi: 10.2174/09298673113206660272. Curr Med Chem. 2014. PMID: 24059226 Review.
The anti-tumor therapeutic ellipticine and its derivatives act as potent anticancer agents via a combined mechanism involving cell cycle arrest and induction of apoptosis. ...In addition, the formation of ellipticine-DNA adducts ultimately can mutate cance …
The anti-tumor therapeutic ellipticine and its derivatives act as potent anticancer agents via a combined mechanism involving …
The kinetics of cancer cells and of HIV1: the problems of cell and virus rebounds and of latency.
Mathé G. Mathé G. Biomed Pharmacother. 1998;52(10):413-20. doi: 10.1016/S0753-3322(99)80018-3. Biomed Pharmacother. 1998. PMID: 9921409 Review.
Hence, the very poor global benefit in cancer medicine registered in the last 50 years. The only cures are seen in child tumors and young adults testis cancer: the immunity reaction being stronger before 40 years of age than after 40 may explain this difference with …
Hence, the very poor global benefit in cancer medicine registered in the last 50 years. The only cures are seen in child tumors and y …
Ellipticine derivatives.
Guthrie RW, Brossi A, Mennona FA, Mullin JG, Kierstead RW, Grunberg E. Guthrie RW, et al. J Med Chem. 1975 Jul;18(7):755-60. doi: 10.1021/jm00241a023. J Med Chem. 1975. PMID: 1151997
Several acyloxy and alkyl derivatives of ellipticine have been prepared. In addition, a modified synthesis leading to the hitherto unobtainable 8,9-dimethoxy- and 8,9-methylenedioxyellipticines is described. ...However, none of the compounds showed activity superior to tha …
Several acyloxy and alkyl derivatives of ellipticine have been prepared. In addition, a modified synthesis leading to the hitherto un …
Synthetic Optimization of Ellipticine and Antitumor Activity of Novel Hexacyclic Derivatives of Ellipticine.
Lin J, Tang M, Zhao R, Du Q, Shen L, Du G, Zhang Y, Li Y, Pan X. Lin J, et al. Curr Pharm Des. 2019;25(33):3578-3589. doi: 10.2174/1381612825666190404122650. Curr Pharm Des. 2019. PMID: 30947658
Fourteen ellipticine hexacyclic derivatives were synthesized. The synthetic compounds were screened for anti-tumor activity in vivo and in vitro, and some of the derivatives had good anti-tumor activity. CONCLUSION: Compared with ellipticine, the compo …
Fourteen ellipticine hexacyclic derivatives were synthesized. The synthetic compounds were screened for anti-tumor activity in …
Cytochrome P450- and peroxidase-mediated oxidation of anticancer alkaloid ellipticine dictates its anti-tumor efficiency.
Stiborová M, Rupertová M, Frei E. Stiborová M, et al. Biochim Biophys Acta. 2011 Jan;1814(1):175-85. doi: 10.1016/j.bbapap.2010.05.016. Epub 2010 Jun 8. Biochim Biophys Acta. 2011. PMID: 20576524 Review.
The aim of this review was to summarize our knowledge on the molecular mechanisms of ellipticine action in the cancer cells. The CYP-mediated ellipticine metabolites 9-hydroxy- and 7-hydroxyellipticine and the product of ellipticine oxidation by peroxi …
The aim of this review was to summarize our knowledge on the molecular mechanisms of ellipticine action in the cancer cells. T …
Anticancer Alkaloids from Trees: Development into Drugs.
Isah T. Isah T. Pharmacogn Rev. 2016 Jul-Dec;10(20):90-99. doi: 10.4103/0973-7847.194047. Pharmacogn Rev. 2016. PMID: 28082790 Free PMC article. Review.
Other important alkaloids isolated from these life forms include rohitukine, harringtonine, acronycine, thalicarpine, usambarensine, ellipticine, and matrines. Studies on their mechanism of action and target on the DNA and protein of cancerous cells aided the development o …
Other important alkaloids isolated from these life forms include rohitukine, harringtonine, acronycine, thalicarpine, usambarensine, elli …
Mix and Shake: A Mild Way to Drug-Loaded Lysozyme Nanoparticles.
Cao C, Tian L, Li J, Raveendran R, Stenzel MH. Cao C, et al. ACS Appl Mater Interfaces. 2024 May 29;16(21):27177-27186. doi: 10.1021/acsami.4c05497. Epub 2024 May 16. ACS Appl Mater Interfaces. 2024. PMID: 38753304
In this process, lysozyme is mixed with hydrophobic drugs (curcumin, ellipticine, and dasatinib) and fructose to prepare lysozyme-based drug particles of around 150 nm in size. ...The results also reveal that lysozyme dual ellipticine/dasatinib curcumin particles en …
In this process, lysozyme is mixed with hydrophobic drugs (curcumin, ellipticine, and dasatinib) and fructose to prepare lysozyme-bas …
G-quadruplex DNA: a novel target for drug design.
Teng FY, Jiang ZZ, Guo M, Tan XZ, Chen F, Xi XG, Xu Y. Teng FY, et al. Cell Mol Life Sci. 2021 Oct;78(19-20):6557-6583. doi: 10.1007/s00018-021-03921-8. Epub 2021 Aug 30. Cell Mol Life Sci. 2021. PMID: 34459951 Free PMC article. Review.
Typical G4 ligands that target promoters and telomeres for drug design are also reviewed, including ellipticine derivatives, quinoxaline analogs, telomestatin analogs, berberine derivatives, and CX-5461, which is currently in advanced phase I/II clinical trials for patient …
Typical G4 ligands that target promoters and telomeres for drug design are also reviewed, including ellipticine derivatives, quinoxal …
403 results